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• W1749809361 abstract "The decade anniversary for genome-wide association studies (GWAS) is approaching, and this experimental approach has commenced a deeper understanding of the genetics underlying complex diseases. In obesity genetics the GIANT (Genetic Investigation of ANthropometric Traits) consortium has played a crucial role, recently with two comprehensive meta-analyses, one focusing on general obesity, analyzing body-mass index (BMI) and the other on fat distribution, focusing on waist-hip ratio adjusted for BMI. With the in silico methods applied in these two studies as the pivot, this review looks into some of the biological knowledge, beginning to emerge from the intricate genomic background behind the genetic determinants of human adiposity. These include synaptic dysfunction, where GWAS pinpoint potential new mechanisms in pathways already known to be linked with obesity." @default.
• W1749809361 created "2016-06-24" @default.
• W1749809361 creator A5050914910 @default.
• W1749809361 creator A5064416982 @default.
• W1749809361 creator A5066665434 @default.
• W1749809361 creator A5069300110 @default.
• W1749809361 date "2015-12-01" @default.
• W1749809361 modified "2023-09-24" @default.
• W1749809361 title "Genome-wide association studies of human adiposity: Zooming in on synapses" @default.
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• W1749809361 doi "https://doi.org/10.1016/j.mce.2015.09.029" @default.
• W1749809361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26427653" @default.
• W1749809361 hasPublicationYear "2015" @default.
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