FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1810581179> ?p ?o ?g. }

• W1810581179 endingPage "1151" @default.
• W1810581179 startingPage "1147" @default.
• W1810581179 abstract "Cryo-electron microscopy (cryo-EM) is rapidly emerging as a powerful tool for protein structure determination at high resolution. Here we report the structure of a complex between Escherichia coli β-galactosidase and the cell-permeant inhibitor phenylethyl β-D-thiogalactopyranoside (PETG), determined by cryo-EM at an average resolution of ~2.2 angstroms (Å). Besides the PETG ligand, we identified densities in the map for ~800 water molecules and for magnesium and sodium ions. Although it is likely that continued advances in detector technology may further enhance resolution, our findings demonstrate that preparation of specimens of adequate quality and intrinsic protein flexibility, rather than imaging or image-processing technologies, now represent the major bottlenecks to routinely achieving resolutions close to 2 Å using single-particle cryo-EM." @default.
• W1810581179 created "2016-06-24" @default.
• W1810581179 creator A5002017099 @default.
• W1810581179 creator A5023944502 @default.
• W1810581179 creator A5026405170 @default.
• W1810581179 creator A5041098204 @default.
• W1810581179 creator A5042412445 @default.
• W1810581179 creator A5058044724 @default.
• W1810581179 creator A5060113449 @default.
• W1810581179 date "2015-06-05" @default.
• W1810581179 modified "2023-10-16" @default.
• W1810581179 title "2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor" @default.
• W1810581179 cites W1545235721 @default.
• W1810581179 cites W1552188451 @default.
• W1810581179 cites W177317313 @default.
• W1810581179 cites W1838465562 @default.
• W1810581179 cites W1964333133 @default.
• W1810581179 cites W1980885982 @default.
• W1810581179 cites W1983912680 @default.
• W1810581179 cites W1986033666 @default.
• W1810581179 cites W1987564900 @default.
• W1810581179 cites W2007217395 @default.
• W1810581179 cites W2013759011 @default.
• W1810581179 cites W2031880123 @default.
• W1810581179 cites W2048826637 @default.
• W1810581179 cites W2060388198 @default.
• W1810581179 cites W2062083170 @default.
• W1810581179 cites W2067374400 @default.
• W1810581179 cites W2069745616 @default.
• W1810581179 cites W2074063726 @default.
• W1810581179 cites W2091223555 @default.
• W1810581179 cites W2095593044 @default.
• W1810581179 cites W2104382086 @default.
• W1810581179 cites W2117756276 @default.
• W1810581179 cites W2124026197 @default.
• W1810581179 cites W2125214575 @default.
• W1810581179 cites W2132629607 @default.
• W1810581179 cites W2140982760 @default.
• W1810581179 cites W2143205611 @default.
• W1810581179 cites W2149360962 @default.
• W1810581179 cites W2149705812 @default.
• W1810581179 cites W2150790075 @default.
• W1810581179 cites W2160559764 @default.
• W1810581179 cites W2161648329 @default.
• W1810581179 cites W2163135112 @default.
• W1810581179 cites W2164659462 @default.
• W1810581179 cites W2169880855 @default.
• W1810581179 doi "https://doi.org/10.1126/science.aab1576" @default.
• W1810581179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6512338" @default.
• W1810581179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25953817" @default.
• W1810581179 hasPublicationYear "2015" @default.
• W1810581179 type Work @default.
• W1810581179 sameAs 1810581179 @default.
• W1810581179 citedByCount "435" @default.
• W1810581179 countsByYear W18105811792015 @default.
• W1810581179 countsByYear W18105811792016 @default.
• W1810581179 countsByYear W18105811792017 @default.
• W1810581179 countsByYear W18105811792018 @default.
• W1810581179 countsByYear W18105811792019 @default.
• W1810581179 countsByYear W18105811792020 @default.
• W1810581179 countsByYear W18105811792021 @default.
• W1810581179 countsByYear W18105811792022 @default.
• W1810581179 countsByYear W18105811792023 @default.
• W1810581179 crossrefType "journal-article" @default.
• W1810581179 hasAuthorship W1810581179A5002017099 @default.
• W1810581179 hasAuthorship W1810581179A5023944502 @default.
• W1810581179 hasAuthorship W1810581179A5026405170 @default.
• W1810581179 hasAuthorship W1810581179A5041098204 @default.
• W1810581179 hasAuthorship W1810581179A5042412445 @default.
• W1810581179 hasAuthorship W1810581179A5058044724 @default.
• W1810581179 hasAuthorship W1810581179A5060113449 @default.
• W1810581179 hasBestOaLocation W18105811791 @default.
• W1810581179 hasConcept C104317684 @default.
• W1810581179 hasConcept C105795698 @default.
• W1810581179 hasConcept C116569031 @default.
• W1810581179 hasConcept C120665830 @default.
• W1810581179 hasConcept C121332964 @default.
• W1810581179 hasConcept C12554922 @default.
• W1810581179 hasConcept C138268822 @default.
• W1810581179 hasConcept C147080431 @default.
• W1810581179 hasConcept C154945302 @default.
• W1810581179 hasConcept C170493617 @default.
• W1810581179 hasConcept C171250308 @default.
• W1810581179 hasConcept C185592680 @default.
• W1810581179 hasConcept C192562407 @default.
• W1810581179 hasConcept C20702342 @default.
• W1810581179 hasConcept C2780598303 @default.
• W1810581179 hasConcept C33923547 @default.
• W1810581179 hasConcept C37407028 @default.
• W1810581179 hasConcept C41008148 @default.
• W1810581179 hasConcept C547475151 @default.
• W1810581179 hasConcept C55493867 @default.
• W1810581179 hasConcept C8010536 @default.
• W1810581179 hasConcept C86803240 @default.
• W1810581179 hasConceptScore W1810581179C104317684 @default.
• W1810581179 hasConceptScore W1810581179C105795698 @default.
• W1810581179 hasConceptScore W1810581179C116569031 @default.
• W1810581179 hasConceptScore W1810581179C120665830 @default.

• next