Matches in SemOpenAlex for { <https://semopenalex.org/work/W1869968315> ?p ?o ?g. }
- W1869968315 endingPage "2528" @default.
- W1869968315 startingPage "2520" @default.
- W1869968315 abstract "The recent finding of a specific receptor for prorrenin/renin (PRR) has brought new insights into the physiology of the renin-angiotensin-aldosterone system. No undoubtable role has been described for this receptor so far. Its role seems to be important in chronic illnesses such as hypertension, possibly participating in the cardiovascular remodeling process, and diabetes where participation in inflammation development has been described. It is not possible, however, to explore the PRR function using classical pharmacological approaches due to the lack of specific agonists or antagonists. Two synthetic peptides have been described to accomplish these roles, but no conclusive data have been provided. There are no X-ray crystallography studies available to describe the structure and potential sites for drug development. So, the aim of this work was to model and theoretically describe the PRR. We describe and characterize the whole receptor protein, its spatial conformation and the potential interactions of PRR with the synthetic peptides available, describing the amino acid residues responsible for these interactions. This information provides the basis for directed development of drugs, seeking to agonize or antagonize PRR activity and study its function in health and ill stages." @default.
- W1869968315 created "2016-06-24" @default.
- W1869968315 creator A5041724997 @default.
- W1869968315 creator A5050323791 @default.
- W1869968315 creator A5073489836 @default.
- W1869968315 creator A5076218998 @default.
- W1869968315 creator A5077301787 @default.
- W1869968315 date "2015-01-01" @default.
- W1869968315 modified "2023-09-30" @default.
- W1869968315 title "Three-dimensional structure and molecular dynamics studies of prorrenin/renin receptor: description of the active site" @default.
- W1869968315 cites W1981021420 @default.
- W1869968315 cites W2013933814 @default.
- W1869968315 cites W2022319844 @default.
- W1869968315 cites W2029667189 @default.
- W1869968315 cites W2048996867 @default.
- W1869968315 cites W2049902088 @default.
- W1869968315 cites W2051491943 @default.
- W1869968315 cites W2053379287 @default.
- W1869968315 cites W2060259273 @default.
- W1869968315 cites W2063638281 @default.
- W1869968315 cites W2065090381 @default.
- W1869968315 cites W2065565793 @default.
- W1869968315 cites W2067174909 @default.
- W1869968315 cites W2070981224 @default.
- W1869968315 cites W2072283710 @default.
- W1869968315 cites W2077776336 @default.
- W1869968315 cites W2082920944 @default.
- W1869968315 cites W2086779432 @default.
- W1869968315 cites W2101668704 @default.
- W1869968315 cites W2102993309 @default.
- W1869968315 cites W2107990955 @default.
- W1869968315 cites W2108403112 @default.
- W1869968315 cites W2112743424 @default.
- W1869968315 cites W2117905193 @default.
- W1869968315 cites W2133881579 @default.
- W1869968315 cites W2146227799 @default.
- W1869968315 cites W2163854178 @default.
- W1869968315 cites W2164706268 @default.
- W1869968315 cites W2168038162 @default.
- W1869968315 cites W2171268876 @default.
- W1869968315 cites W2314488714 @default.
- W1869968315 cites W2317816676 @default.
- W1869968315 cites W4249732117 @default.
- W1869968315 cites W4252397535 @default.
- W1869968315 doi "https://doi.org/10.1039/c5mb00342c" @default.
- W1869968315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26177886" @default.
- W1869968315 hasPublicationYear "2015" @default.
- W1869968315 type Work @default.
- W1869968315 sameAs 1869968315 @default.
- W1869968315 citedByCount "3" @default.
- W1869968315 countsByYear W18699683152016 @default.
- W1869968315 countsByYear W18699683152022 @default.
- W1869968315 countsByYear W18699683152023 @default.
- W1869968315 crossrefType "journal-article" @default.
- W1869968315 hasAuthorship W1869968315A5041724997 @default.
- W1869968315 hasAuthorship W1869968315A5050323791 @default.
- W1869968315 hasAuthorship W1869968315A5073489836 @default.
- W1869968315 hasAuthorship W1869968315A5076218998 @default.
- W1869968315 hasAuthorship W1869968315A5077301787 @default.
- W1869968315 hasConcept C104317684 @default.
- W1869968315 hasConcept C134018914 @default.
- W1869968315 hasConcept C135285700 @default.
- W1869968315 hasConcept C14036430 @default.
- W1869968315 hasConcept C167625842 @default.
- W1869968315 hasConcept C170493617 @default.
- W1869968315 hasConcept C185592680 @default.
- W1869968315 hasConcept C198710026 @default.
- W1869968315 hasConcept C203014093 @default.
- W1869968315 hasConcept C2776914184 @default.
- W1869968315 hasConcept C2780035454 @default.
- W1869968315 hasConcept C2994376932 @default.
- W1869968315 hasConcept C55493867 @default.
- W1869968315 hasConcept C60644358 @default.
- W1869968315 hasConcept C64903051 @default.
- W1869968315 hasConcept C70721500 @default.
- W1869968315 hasConcept C84393581 @default.
- W1869968315 hasConcept C86803240 @default.
- W1869968315 hasConcept C95444343 @default.
- W1869968315 hasConcept C98274493 @default.
- W1869968315 hasConceptScore W1869968315C104317684 @default.
- W1869968315 hasConceptScore W1869968315C134018914 @default.
- W1869968315 hasConceptScore W1869968315C135285700 @default.
- W1869968315 hasConceptScore W1869968315C14036430 @default.
- W1869968315 hasConceptScore W1869968315C167625842 @default.
- W1869968315 hasConceptScore W1869968315C170493617 @default.
- W1869968315 hasConceptScore W1869968315C185592680 @default.
- W1869968315 hasConceptScore W1869968315C198710026 @default.
- W1869968315 hasConceptScore W1869968315C203014093 @default.
- W1869968315 hasConceptScore W1869968315C2776914184 @default.
- W1869968315 hasConceptScore W1869968315C2780035454 @default.
- W1869968315 hasConceptScore W1869968315C2994376932 @default.
- W1869968315 hasConceptScore W1869968315C55493867 @default.
- W1869968315 hasConceptScore W1869968315C60644358 @default.
- W1869968315 hasConceptScore W1869968315C64903051 @default.
- W1869968315 hasConceptScore W1869968315C70721500 @default.
- W1869968315 hasConceptScore W1869968315C84393581 @default.
- W1869968315 hasConceptScore W1869968315C86803240 @default.
- W1869968315 hasConceptScore W1869968315C95444343 @default.