FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888258802> ?p ?o ?g. }

• W1888258802 endingPage "1464" @default.
• W1888258802 startingPage "1459" @default.
• W1888258802 abstract "Plasmids containing the bacterial gpt gene under control of the simian virus 40 promoter were transfected into a simian virus 40-transformed human fibroblast line. Two transfectants, E2 and C10, which contain stably integrated single copies of the gpt gene, were isolated. These two lines produce Gpt- variants spontaneously with a frequency of about 10(-4). We carried out a detailed molecular analysis of the spectrum of alterations which gave rise to the Gpt- phenotype in these variants. DNA from 14 of 19 Gpt- derivatives of one of the cell lines (E2) contains deletions or rearrangements of gpt-containing sequences. In four of the remaining five lines, the Gpt- phenotype was correlated with reduced levels of expression rather than with changes in the gross structure of the gpt gene, and it was possible to reactivate the gpt gene. In one Gpt- line, gpt mRNA was present at normal levels, but no active enzyme was produced. Spontaneous Gpt- derivatives of the other cell line (C10) produced a completely different spectrum of alterations. Very few deletions were found, but several derivatives contained additional extrachromosomal gpt sequences, and, remarkably, in two other Gpt- lines, gpt-containing sequences were amplified more than 100-fold. The phenotypes of the majority of the Gpt- derivatives of C10 could be attributed to alterations in gene expression caused by methylation." @default.
• W1888258802 created "2016-06-24" @default.
• W1888258802 creator A5005509014 @default.
• W1888258802 creator A5031045209 @default.
• W1888258802 creator A5037430044 @default.
• W1888258802 creator A5048471316 @default.
• W1888258802 creator A5066781741 @default.
• W1888258802 creator A5072928202 @default.
• W1888258802 creator A5073072762 @default.
• W1888258802 creator A5091464519 @default.
• W1888258802 date "1987-04-01" @default.
• W1888258802 modified "2023-09-26" @default.
• W1888258802 title "Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation." @default.
• W1888258802 cites W1499581586 @default.
• W1888258802 cites W1510707687 @default.
• W1888258802 cites W1546323225 @default.
• W1888258802 cites W1772905558 @default.
• W1888258802 cites W1878410949 @default.
• W1888258802 cites W1885191048 @default.
• W1888258802 cites W1965372133 @default.
• W1888258802 cites W1970078675 @default.
• W1888258802 cites W1972920532 @default.
• W1888258802 cites W1980826960 @default.
• W1888258802 cites W1998162329 @default.
• W1888258802 cites W2000838016 @default.
• W1888258802 cites W2004696590 @default.
• W1888258802 cites W2025898591 @default.
• W1888258802 cites W2032980997 @default.
• W1888258802 cites W2036303296 @default.
• W1888258802 cites W2043612650 @default.
• W1888258802 cites W2048066539 @default.
• W1888258802 cites W2058497687 @default.
• W1888258802 cites W2066022960 @default.
• W1888258802 cites W2072210093 @default.
• W1888258802 cites W2078951223 @default.
• W1888258802 cites W2098548034 @default.
• W1888258802 cites W2105032695 @default.
• W1888258802 cites W2118929543 @default.
• W1888258802 cites W2144634347 @default.
• W1888258802 cites W2163141779 @default.
• W1888258802 doi "https://doi.org/10.1128/mcb.7.4.1459" @default.
• W1888258802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/365234" @default.
• W1888258802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3110595" @default.
• W1888258802 hasPublicationYear "1987" @default.
• W1888258802 type Work @default.
• W1888258802 sameAs 1888258802 @default.
• W1888258802 citedByCount "47" @default.
• W1888258802 countsByYear W18882588022012 @default.
• W1888258802 countsByYear W18882588022018 @default.
• W1888258802 countsByYear W18882588022019 @default.
• W1888258802 crossrefType "journal-article" @default.
• W1888258802 hasAuthorship W1888258802A5005509014 @default.
• W1888258802 hasAuthorship W1888258802A5031045209 @default.
• W1888258802 hasAuthorship W1888258802A5037430044 @default.
• W1888258802 hasAuthorship W1888258802A5048471316 @default.
• W1888258802 hasAuthorship W1888258802A5066781741 @default.
• W1888258802 hasAuthorship W1888258802A5072928202 @default.
• W1888258802 hasAuthorship W1888258802A5073072762 @default.
• W1888258802 hasAuthorship W1888258802A5091464519 @default.
• W1888258802 hasBestOaLocation W18882588022 @default.
• W1888258802 hasConcept C104317684 @default.
• W1888258802 hasConcept C127716648 @default.
• W1888258802 hasConcept C150194340 @default.
• W1888258802 hasConcept C153911025 @default.
• W1888258802 hasConcept C190727270 @default.
• W1888258802 hasConcept C22744801 @default.
• W1888258802 hasConcept C33288867 @default.
• W1888258802 hasConcept C54009773 @default.
• W1888258802 hasConcept C54355233 @default.
• W1888258802 hasConcept C81885089 @default.
• W1888258802 hasConcept C86803240 @default.
• W1888258802 hasConcept C89684784 @default.
• W1888258802 hasConceptScore W1888258802C104317684 @default.
• W1888258802 hasConceptScore W1888258802C127716648 @default.
• W1888258802 hasConceptScore W1888258802C150194340 @default.
• W1888258802 hasConceptScore W1888258802C153911025 @default.
• W1888258802 hasConceptScore W1888258802C190727270 @default.
• W1888258802 hasConceptScore W1888258802C22744801 @default.
• W1888258802 hasConceptScore W1888258802C33288867 @default.
• W1888258802 hasConceptScore W1888258802C54009773 @default.
• W1888258802 hasConceptScore W1888258802C54355233 @default.
• W1888258802 hasConceptScore W1888258802C81885089 @default.
• W1888258802 hasConceptScore W1888258802C86803240 @default.
• W1888258802 hasConceptScore W1888258802C89684784 @default.
• W1888258802 hasIssue "4" @default.
• W1888258802 hasLocation W18882588021 @default.
• W1888258802 hasLocation W18882588022 @default.
• W1888258802 hasOpenAccess W1888258802 @default.
• W1888258802 hasPrimaryLocation W18882588021 @default.
• W1888258802 hasRelatedWork W1969774671 @default.
• W1888258802 hasRelatedWork W2072526150 @default.
• W1888258802 hasRelatedWork W2076047342 @default.
• W1888258802 hasRelatedWork W2094888444 @default.
• W1888258802 hasRelatedWork W2348478723 @default.
• W1888258802 hasRelatedWork W2365306427 @default.
• W1888258802 hasRelatedWork W2380962287 @default.
• W1888258802 hasRelatedWork W2410054136 @default.
• W1888258802 hasRelatedWork W4283027398 @default.

• next