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• W1890198889 abstract "Colon cancer is the third most common type of cancer and the second leading cause of cancer-related death in the western world. Many epidemiological studies have shown that lifestyle and intake of various food components influence the colon carcinogenesis. Novel concepts such as nutrigenomics and nutrigenetics which study the interaction between diet and genes with common goal to optimize health through personalization of diet, provide approaches to elucidate the complex relationship between nutrients and genetic polymorphisms involved in various diseases like colon cancer. Nutrigenetics of colon cancer is based on correlation between folate metabolism and polymorphisms in the genes encoding crucial enzymes in folate metabolism pathway. The folate pathway influences abberant pyrimidine and purine synthesis as well as the global DNA hypomethylation and hypermethylation of tumor supressor genes such as APC, hMLH1, p16 and E-cadherin in colon cancer. In addition, polymorphisms in the MTHFR, TYMS, MTR, MTRR, RFC, DHFR and other genes involved in the folate pathway have been shown to influence colon carcinogenesis. The central role of the folate pathway in the cell has made it a target for a variety of chemotherapeutics. Polymorphisms in the genes encoding crucial enzymes in the folate pathway might have an important role in the pharmacogenetics and nutrigenetics of colon cancer." @default.
• W1890198889 created "2016-06-24" @default.
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• W1890198889 date "2009-03-31" @default.
• W1890198889 modified "2023-10-18" @default.
• W1890198889 title "Nutrigenetics and colon cancer" @default.
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