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• W1919384911 endingPage "2356" @default.
• W1919384911 startingPage "2334" @default.
• W1919384911 abstract "c-erbB-2 (HER-2, c-neu) might play a role as a predictive factor in breast cancer. However, the clinical utility of the marker in this disease is still not established. We conducted a critical analysis of the literature, in which we reviewed the factors that contribute to the lack of acceptance of c-erbB-2 for clinical use and attempted to determine the predictive role of c-erbB-2 for response to specific therapies.We conducted a MEDLINE literature search using the keywords c-erbB-2, HER2, neu, and breast cancer, reviewed the references included in each publication, and reviewed abstracts that have been reported in the 1997-2000 proceedings to the American Association of Cancer Research and American Society for Clinical Oncology annual meetings.The preclinical and clinical data reported to date suggest that amplification or overexpression of c-erbB-2 is a weak to moderate negative pure prognostic factor. c-erbB-2 seems to be a weak to moderate negative predictive factor for response to endocrine therapy. The marker is also a moderate negative predictive factor for response to alkylating agents and a moderate positive predictive factor for response to anthracyclines. The data regarding response to taxanes or radiotherapy are not sufficient to make recommendations regarding treatment decision making. Finally, c-erbB-2 is a strong predictive factor for response to trastuzumab.We conclude that, in the adjuvant setting, c-erbB-2 status should not be used to determine whether a woman should receive adjuvant systemic therapy (weak prognostic factor). In addition, c-erbB-2 status should not be used to determine whether a patient should receive endocrine therapy. When adjuvant chemotherapy is recommended, anthracycline-based therapy should be the preferred regimen for c-erbB-2-positive patients. However, when anthracyclines are contraindicated, alkylating agent-based therapy should not be withheld. To determine the true predictive role and strength of the marker for response to each therapy, prospective randomized clinical trials or formal meta-analyses are required." @default.
• W1919384911 created "2016-06-24" @default.
• W1919384911 creator A5056530735 @default.
• W1919384911 creator A5069748055 @default.
• W1919384911 creator A5084241748 @default.
• W1919384911 date "2001-04-15" @default.
• W1919384911 modified "2023-10-17" @default.
• W1919384911 title "When Is a Tumor Marker Ready for Prime Time? A Case Study of c-<i>erb</i>B-2 as a Predictive Factor in Breast Cancer" @default.
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• W1919384911 doi "https://doi.org/10.1200/jco.2001.19.8.2334" @default.
• W1919384911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11304787" @default.
• W1919384911 hasPublicationYear "2001" @default.
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