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• W1936699800 abstract "β-Secretase continues to be an attractive drug discovery target for the therapeutic intervention of Alzheimer's disease (AD). This enzyme plays a critical role in the production of neurotoxic β-amyloid (Aβ) peptides in the brain. Over the years, extensive research efforts have led to the development of many promising classes of inhibitors against this protease. Many small-molecule, peptidomimetic, and nonpeptide β-secretase inhibitors have now overcome the key challenging development hurdles such as selectivity and brain penetration. A number of inhibitors have also shown further promise in reducing brain Aβ and rescuing cognitive decline in animal models. Recently, several β-secretase inhibitors have entered into preclinical and phase I studies, and at least one of these inhibitors has advanced to phase II/III human trials. The outlook on β-secretase inhibitor drugs for the treatment of AD patients is discussed herein." @default.
• W1936699800 created "2016-06-24" @default.
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• W1936699800 date "2015-07-03" @default.
• W1936699800 modified "2023-10-16" @default.
• W1936699800 title "Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer’s Disease" @default.
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• W1936699800 doi "https://doi.org/10.1002/cmdc.201500216" @default.
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