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• W1943482912 abstract "Glucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP-1 or preventing its degradation, attention is now turning towards the L-cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP-1 in vivo. Understanding the mechanisms underlying GLP-1 release from L-cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L-cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L-cell nutrient responsiveness." @default.
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• W1943482912 date "2009-01-01" @default.
• W1943482912 modified "2023-09-23" @default.
• W1943482912 title "Nutritional regulation of glucagon-like peptide-1 secretion" @default.
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• W1943482912 doi "https://doi.org/10.1113/jphysiol.2008.164012" @default.
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