Matches in SemOpenAlex for { <https://semopenalex.org/work/W1949550695> ?p ?o ?g. }
- W1949550695 endingPage "408" @default.
- W1949550695 startingPage "397" @default.
- W1949550695 abstract "DIXDC1 (Dishevelled-Axin domain containing 1) is a DIX (Dishevelled-Axin) domain-possessing protein that promotes colon cancer cell proliferation and increases the invasion and migration ability of non-small-cell lung cancer via the PI3K pathway. As a positive regulator of the Wnt/β-catenin pathway, the biological role of DIXDC1 in human gastric cancer and the relationship between DIXDC1 and the Wnt pathway are unclear. In the current study, the upregulation of DIXDC1 was detected in gastric cancer and was associated with advanced TNM stage cancer, lymph node metastasis, and poor prognosis. We also found that the overexpression of DIXDC1 could promote the invasion and migration of gastric cancer cells. The upregulation of MMPs and the downregulation of E-cadherin were found to be involved in the process. DIXDC1 enhanced β-catenin nuclear accumulation, which activated the Wnt pathway. Additionally, the inhibition of β-catenin in DIXDC1-overexpressing cells reversed the metastasis promotion effects of DIXDC1. These results demonstrate that the expression of DIXDC1 is associated with poor prognosis of gastric cancer patients and that DIXDC1 promotes gastric cancer invasion and metastasis through the activation of the Wnt pathway; E-cadherin and MMPs are also involved in this process. © 2015 Wiley Periodicals, Inc." @default.
- W1949550695 created "2016-06-24" @default.
- W1949550695 creator A5020155521 @default.
- W1949550695 creator A5020954259 @default.
- W1949550695 creator A5023037940 @default.
- W1949550695 creator A5034490033 @default.
- W1949550695 creator A5038992198 @default.
- W1949550695 creator A5060642200 @default.
- W1949550695 creator A5062344658 @default.
- W1949550695 creator A5067429103 @default.
- W1949550695 creator A5069231622 @default.
- W1949550695 creator A5073216396 @default.
- W1949550695 creator A5079745195 @default.
- W1949550695 date "2015-02-03" @default.
- W1949550695 modified "2023-10-02" @default.
- W1949550695 title "DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis" @default.
- W1949550695 cites W1502344119 @default.
- W1949550695 cites W1601070508 @default.
- W1949550695 cites W1965225412 @default.
- W1949550695 cites W1966580641 @default.
- W1949550695 cites W1973223773 @default.
- W1949550695 cites W1988021064 @default.
- W1949550695 cites W1999310339 @default.
- W1949550695 cites W1999390554 @default.
- W1949550695 cites W2000828354 @default.
- W1949550695 cites W2001992345 @default.
- W1949550695 cites W2003380289 @default.
- W1949550695 cites W2003395833 @default.
- W1949550695 cites W2006419043 @default.
- W1949550695 cites W2013329576 @default.
- W1949550695 cites W2021226225 @default.
- W1949550695 cites W2030330090 @default.
- W1949550695 cites W2034309830 @default.
- W1949550695 cites W2038370775 @default.
- W1949550695 cites W2047472905 @default.
- W1949550695 cites W2058192196 @default.
- W1949550695 cites W2061572587 @default.
- W1949550695 cites W2073204626 @default.
- W1949550695 cites W2078459317 @default.
- W1949550695 cites W2092244737 @default.
- W1949550695 cites W2093921289 @default.
- W1949550695 cites W2129860749 @default.
- W1949550695 cites W2139219682 @default.
- W1949550695 cites W2143468862 @default.
- W1949550695 cites W2148294117 @default.
- W1949550695 cites W2149726781 @default.
- W1949550695 cites W2154345686 @default.
- W1949550695 cites W2154589460 @default.
- W1949550695 cites W2155507705 @default.
- W1949550695 cites W2155554726 @default.
- W1949550695 cites W2158021558 @default.
- W1949550695 cites W2168592676 @default.
- W1949550695 doi "https://doi.org/10.1002/mc.22290" @default.
- W1949550695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25648220" @default.
- W1949550695 hasPublicationYear "2015" @default.
- W1949550695 type Work @default.
- W1949550695 sameAs 1949550695 @default.
- W1949550695 citedByCount "29" @default.
- W1949550695 countsByYear W19495506952015 @default.
- W1949550695 countsByYear W19495506952016 @default.
- W1949550695 countsByYear W19495506952017 @default.
- W1949550695 countsByYear W19495506952018 @default.
- W1949550695 countsByYear W19495506952019 @default.
- W1949550695 countsByYear W19495506952020 @default.
- W1949550695 countsByYear W19495506952021 @default.
- W1949550695 countsByYear W19495506952022 @default.
- W1949550695 crossrefType "journal-article" @default.
- W1949550695 hasAuthorship W1949550695A5020155521 @default.
- W1949550695 hasAuthorship W1949550695A5020954259 @default.
- W1949550695 hasAuthorship W1949550695A5023037940 @default.
- W1949550695 hasAuthorship W1949550695A5034490033 @default.
- W1949550695 hasAuthorship W1949550695A5038992198 @default.
- W1949550695 hasAuthorship W1949550695A5060642200 @default.
- W1949550695 hasAuthorship W1949550695A5062344658 @default.
- W1949550695 hasAuthorship W1949550695A5067429103 @default.
- W1949550695 hasAuthorship W1949550695A5069231622 @default.
- W1949550695 hasAuthorship W1949550695A5073216396 @default.
- W1949550695 hasAuthorship W1949550695A5079745195 @default.
- W1949550695 hasConcept C104317684 @default.
- W1949550695 hasConcept C107300179 @default.
- W1949550695 hasConcept C121608353 @default.
- W1949550695 hasConcept C127561419 @default.
- W1949550695 hasConcept C137620995 @default.
- W1949550695 hasConcept C2775928862 @default.
- W1949550695 hasConcept C2779013556 @default.
- W1949550695 hasConcept C2781018059 @default.
- W1949550695 hasConcept C29537977 @default.
- W1949550695 hasConcept C30145163 @default.
- W1949550695 hasConcept C502942594 @default.
- W1949550695 hasConcept C54355233 @default.
- W1949550695 hasConcept C55493867 @default.
- W1949550695 hasConcept C62478195 @default.
- W1949550695 hasConcept C86554907 @default.
- W1949550695 hasConcept C86803240 @default.
- W1949550695 hasConcept C95444343 @default.
- W1949550695 hasConcept C96232424 @default.
- W1949550695 hasConceptScore W1949550695C104317684 @default.
- W1949550695 hasConceptScore W1949550695C107300179 @default.