FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967568501> ?p ?o ?g. }

• W1967568501 endingPage "1205" @default.
• W1967568501 startingPage "1199" @default.
• W1967568501 abstract "Abstract In the treatment of Alzheimer's disease tacrine, a cholinesterase inhibitor, is not the drug of choice due to its low oral bioavailability, extensive hepatic first-pass effect, rapid clearance from the systemic circulation, pronounced hepatotoxicity, and the availability of drugs better than tacrine in the same pharmacological class. Hence, the aim of this investigation was to ascertain the possibility of direct nose-to-brain delivery of tacrine to improve bioavailability, to avoid the first-pass effect and to minimize hepatotoxicity. Tacrine solution (TS) in propylene glycol was radiolabelled with 99mTc (technetium) and administered in BALB/c mice intranasally (i.n.) and intravenously (i.v.). Drug concentrations in blood and brain were determined at predetermined time intervals post dosing. Drug targeting efficiency (DTE %) and the brain drug direct transport percentage (DTP %) were calculated to evaluate the brain targeting efficiency. Brain scintigraphy imaging in rabbits was performed to ascertain the uptake of the drug into the brain. Tacrine solution was effectively labelled with 99mTc and was found to be stable and suitable for in-vivo studies. Following intranasal administration tacrine was delivered quickly (Tmax 60 min) to the brain compared with intravenous administration (Tmax 120 min). The brain/blood ratios of the drug were found to be higher for [99mTc]TSi.n. compared with [99mTc]TSi.v. at all time points. The DTE (207.23%) and DTP (51.75%) following intranasal administration suggested that part of tacrine was directly transported to brain from the nasal cavity. Rabbit brain scintigraphy imaging showed higher uptake of the drug into the brain following intranasal administration compared with intravenous administration. The results showed that tacrine could be directly transported into the brain from the nasal cavity and intranasal administration resulted in higher bioavailability of drug with reduced distribution into non-targeted tissues. This selective localization of tacrine in the brain may be helpful in reducing dose, frequency of dosing and dose-dependent side effects, and may prove an interesting new approach in delivery of the drug to the brain for the treatment of Alzheimer's disease." @default.
• W1967568501 created "2016-06-24" @default.
• W1967568501 creator A5019315191 @default.
• W1967568501 creator A5022699290 @default.
• W1967568501 creator A5030417466 @default.
• W1967568501 creator A5085201403 @default.
• W1967568501 creator A5091197960 @default.
• W1967568501 date "2007-09-01" @default.
• W1967568501 modified "2023-10-10" @default.
• W1967568501 title "Nose-to-brain delivery of tacrine" @default.
• W1967568501 cites W1500510737 @default.
• W1967568501 cites W1969953999 @default.
• W1967568501 cites W1973304468 @default.
• W1967568501 cites W1991264734 @default.
• W1967568501 cites W2000772129 @default.
• W1967568501 cites W2021438826 @default.
• W1967568501 cites W2022176389 @default.
• W1967568501 cites W2030924957 @default.
• W1967568501 cites W2046098352 @default.
• W1967568501 cites W2047173091 @default.
• W1967568501 cites W2048302866 @default.
• W1967568501 cites W2051398024 @default.
• W1967568501 cites W2058357928 @default.
• W1967568501 cites W2059944224 @default.
• W1967568501 cites W2061770334 @default.
• W1967568501 cites W2063626452 @default.
• W1967568501 cites W2065852578 @default.
• W1967568501 cites W2067157437 @default.
• W1967568501 cites W2073614877 @default.
• W1967568501 cites W2077756131 @default.
• W1967568501 cites W2083588057 @default.
• W1967568501 cites W2085305367 @default.
• W1967568501 cites W2089828740 @default.
• W1967568501 cites W2091322268 @default.
• W1967568501 cites W2094349222 @default.
• W1967568501 cites W2095842386 @default.
• W1967568501 cites W2103552620 @default.
• W1967568501 cites W2112689297 @default.
• W1967568501 cites W2114179943 @default.
• W1967568501 cites W2134499687 @default.
• W1967568501 cites W2149629218 @default.
• W1967568501 cites W2163771644 @default.
• W1967568501 cites W33005929 @default.
• W1967568501 cites W4242215325 @default.
• W1967568501 cites W4318443594 @default.
• W1967568501 doi "https://doi.org/10.1211/jpp.59.9.0003" @default.
• W1967568501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17883890" @default.
• W1967568501 hasPublicationYear "2007" @default.
• W1967568501 type Work @default.
• W1967568501 sameAs 1967568501 @default.
• W1967568501 citedByCount "41" @default.
• W1967568501 countsByYear W19675685012012 @default.
• W1967568501 countsByYear W19675685012013 @default.
• W1967568501 countsByYear W19675685012014 @default.
• W1967568501 countsByYear W19675685012015 @default.
• W1967568501 countsByYear W19675685012016 @default.
• W1967568501 countsByYear W19675685012018 @default.
• W1967568501 countsByYear W19675685012019 @default.
• W1967568501 countsByYear W19675685012020 @default.
• W1967568501 countsByYear W19675685012021 @default.
• W1967568501 countsByYear W19675685012022 @default.
• W1967568501 crossrefType "journal-article" @default.
• W1967568501 hasAuthorship W1967568501A5019315191 @default.
• W1967568501 hasAuthorship W1967568501A5022699290 @default.
• W1967568501 hasAuthorship W1967568501A5030417466 @default.
• W1967568501 hasAuthorship W1967568501A5085201403 @default.
• W1967568501 hasAuthorship W1967568501A5091197960 @default.
• W1967568501 hasBestOaLocation W19675685011 @default.
• W1967568501 hasConcept C112705442 @default.
• W1967568501 hasConcept C150903083 @default.
• W1967568501 hasConcept C181199279 @default.
• W1967568501 hasConcept C181389837 @default.
• W1967568501 hasConcept C185592680 @default.
• W1967568501 hasConcept C207001950 @default.
• W1967568501 hasConcept C2777056448 @default.
• W1967568501 hasConcept C2778816929 @default.
• W1967568501 hasConcept C2779046751 @default.
• W1967568501 hasConcept C2780035454 @default.
• W1967568501 hasConcept C55493867 @default.
• W1967568501 hasConcept C71924100 @default.
• W1967568501 hasConcept C85663871 @default.
• W1967568501 hasConcept C86803240 @default.
• W1967568501 hasConcept C98274493 @default.
• W1967568501 hasConceptScore W1967568501C112705442 @default.
• W1967568501 hasConceptScore W1967568501C150903083 @default.
• W1967568501 hasConceptScore W1967568501C181199279 @default.
• W1967568501 hasConceptScore W1967568501C181389837 @default.
• W1967568501 hasConceptScore W1967568501C185592680 @default.
• W1967568501 hasConceptScore W1967568501C207001950 @default.
• W1967568501 hasConceptScore W1967568501C2777056448 @default.
• W1967568501 hasConceptScore W1967568501C2778816929 @default.
• W1967568501 hasConceptScore W1967568501C2779046751 @default.
• W1967568501 hasConceptScore W1967568501C2780035454 @default.
• W1967568501 hasConceptScore W1967568501C55493867 @default.
• W1967568501 hasConceptScore W1967568501C71924100 @default.
• W1967568501 hasConceptScore W1967568501C85663871 @default.
• W1967568501 hasConceptScore W1967568501C86803240 @default.
• W1967568501 hasConceptScore W1967568501C98274493 @default.

• next