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• W1967702968 abstract "SUMMARY Sodium antimony gluconate (SAG) is the mainstay of treatment for visceral leishmaniasis (VL) or kala-azar. In view of the increasing incidence of refractoriness to SAG in India, we compared the levels of parasite-specific IgG and IgG subclasses in 20 longitudinally followed up kala-azar patients. In both SAG-responsive (n = 10) and unresponsive patients (n = 10), the levels of total IgG, IgG1, IgG2, IgG3 and IgG4 were increased, the rank order being IgG1 &gt; IgG2 &gt; IgG3 = IgG4. Following treatment, a significant decrease in total IgG and the four subclasses occurred in the SAG-responsive group, whereas in the SAG-unresponsive group these levels were unchanged or slightly increased. Therefore, monitoring of IgG1 and IgG2 levels in Indian kala-azar patients is a good serologic alternative to monitoring the disease status." @default.
• W1967702968 created "2016-06-24" @default.
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• W1967702968 date "1998-12-01" @default.
• W1967702968 modified "2023-10-12" @default.
• W1967702968 title "Distribution of IgG subclasses in antimonial unresponsive Indian kala-azar patients" @default.
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• W1967702968 doi "https://doi.org/10.1046/j.1365-2249.1998.00752.x" @default.
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