Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968820512> ?p ?o ?g. }
- W1968820512 endingPage "738" @default.
- W1968820512 startingPage "732" @default.
- W1968820512 abstract "Atherosclerosis and its complications are major causes of death all over the world. One of the major risks of atherosclerosis is hypercholesterolemia. During atherosclerosis, oxidized low density lipoprotein (oxLDL) regulates CD36-mediated activation of c-jun amino terminal kinase-1 (JNK1) and modulates matrix metalloproteinase (MMP) induction which stimulates inflammation with an invasion of monocytes. Additionally, inhibition of proteasome leads to an accumulation of c-jun and phosphorylated c-jun and activation of activator protein-1 (AP-1) related increase of MMP expression. We have previously reported a significant increase in cluster of differentiation 36 (CD36) mRNA levels in hypercholesterolemic rabbits and shown that vitamin E treatment prevented the cholesterol induced increase in CD36 mRNA expression. In the present study, our aim is to identify the signaling molecules/transcription factors involved in the progression of atherosclerosis following CD36 activation in an in vivo model of hypercholesterolemic (induced by 2% cholesterol containing diet) rabbits. In this direction, proteasomal activities by fluorometry and c-jun, phospo c-jun, JNK1, MMP-9 expressions by quantitative RT-PCR and immunoblotting were tested in aortic tissues. The effects of vitamin E on these changes were also investigated in this model. As a result, c-jun was phosphorylated following decreased proteasomal degradation in hypercholesterolemic group. MMP-9 expression was also increased in cholesterol group rabbits contributing to the development of atherosclerosis. In addition, vitamin E showed its effect by decreasing MMP-9 levels and phosphorylation of c-jun." @default.
- W1968820512 created "2016-06-24" @default.
- W1968820512 creator A5002282233 @default.
- W1968820512 creator A5017111402 @default.
- W1968820512 creator A5022568845 @default.
- W1968820512 creator A5026363860 @default.
- W1968820512 creator A5035465773 @default.
- W1968820512 date "2014-01-01" @default.
- W1968820512 modified "2023-10-15" @default.
- W1968820512 title "Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis" @default.
- W1968820512 cites W1481220364 @default.
- W1968820512 cites W1974468825 @default.
- W1968820512 cites W1979639303 @default.
- W1968820512 cites W1981029023 @default.
- W1968820512 cites W1985777107 @default.
- W1968820512 cites W1992313261 @default.
- W1968820512 cites W1995533869 @default.
- W1968820512 cites W2002812554 @default.
- W1968820512 cites W2005294216 @default.
- W1968820512 cites W2006874875 @default.
- W1968820512 cites W2012221118 @default.
- W1968820512 cites W2018434227 @default.
- W1968820512 cites W2026873360 @default.
- W1968820512 cites W2027008375 @default.
- W1968820512 cites W2029174607 @default.
- W1968820512 cites W2032143273 @default.
- W1968820512 cites W2033284291 @default.
- W1968820512 cites W2035892035 @default.
- W1968820512 cites W2052696587 @default.
- W1968820512 cites W2054963713 @default.
- W1968820512 cites W2062275234 @default.
- W1968820512 cites W2062950088 @default.
- W1968820512 cites W2071322608 @default.
- W1968820512 cites W2077187989 @default.
- W1968820512 cites W2086304683 @default.
- W1968820512 cites W2087549039 @default.
- W1968820512 cites W2088590723 @default.
- W1968820512 cites W2089561842 @default.
- W1968820512 cites W2107919301 @default.
- W1968820512 cites W2107949770 @default.
- W1968820512 cites W2122115743 @default.
- W1968820512 cites W2144854996 @default.
- W1968820512 cites W2145960580 @default.
- W1968820512 cites W2147993424 @default.
- W1968820512 cites W2149720080 @default.
- W1968820512 cites W2149849602 @default.
- W1968820512 cites W2152555940 @default.
- W1968820512 cites W2158969445 @default.
- W1968820512 cites W2166987747 @default.
- W1968820512 cites W2168444374 @default.
- W1968820512 cites W2329404090 @default.
- W1968820512 cites W4296979652 @default.
- W1968820512 doi "https://doi.org/10.1016/j.redox.2014.02.007" @default.
- W1968820512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4085352" @default.
- W1968820512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25009774" @default.
- W1968820512 hasPublicationYear "2014" @default.
- W1968820512 type Work @default.
- W1968820512 sameAs 1968820512 @default.
- W1968820512 citedByCount "23" @default.
- W1968820512 countsByYear W19688205122015 @default.
- W1968820512 countsByYear W19688205122017 @default.
- W1968820512 countsByYear W19688205122018 @default.
- W1968820512 countsByYear W19688205122019 @default.
- W1968820512 countsByYear W19688205122020 @default.
- W1968820512 countsByYear W19688205122021 @default.
- W1968820512 countsByYear W19688205122022 @default.
- W1968820512 countsByYear W19688205122023 @default.
- W1968820512 crossrefType "journal-article" @default.
- W1968820512 hasAuthorship W1968820512A5002282233 @default.
- W1968820512 hasAuthorship W1968820512A5017111402 @default.
- W1968820512 hasAuthorship W1968820512A5022568845 @default.
- W1968820512 hasAuthorship W1968820512A5026363860 @default.
- W1968820512 hasAuthorship W1968820512A5035465773 @default.
- W1968820512 hasBestOaLocation W19688205121 @default.
- W1968820512 hasConcept C104317684 @default.
- W1968820512 hasConcept C109523444 @default.
- W1968820512 hasConcept C11960822 @default.
- W1968820512 hasConcept C126322002 @default.
- W1968820512 hasConcept C134018914 @default.
- W1968820512 hasConcept C170493617 @default.
- W1968820512 hasConcept C184235292 @default.
- W1968820512 hasConcept C185592680 @default.
- W1968820512 hasConcept C2776914184 @default.
- W1968820512 hasConcept C2778163477 @default.
- W1968820512 hasConcept C2779087070 @default.
- W1968820512 hasConcept C2779828298 @default.
- W1968820512 hasConcept C55493867 @default.
- W1968820512 hasConcept C62478195 @default.
- W1968820512 hasConcept C71924100 @default.
- W1968820512 hasConcept C86339819 @default.
- W1968820512 hasConcept C86803240 @default.
- W1968820512 hasConceptScore W1968820512C104317684 @default.
- W1968820512 hasConceptScore W1968820512C109523444 @default.
- W1968820512 hasConceptScore W1968820512C11960822 @default.
- W1968820512 hasConceptScore W1968820512C126322002 @default.
- W1968820512 hasConceptScore W1968820512C134018914 @default.
- W1968820512 hasConceptScore W1968820512C170493617 @default.
- W1968820512 hasConceptScore W1968820512C184235292 @default.