Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969103696> ?p ?o ?g. }
- W1969103696 endingPage "12498" @default.
- W1969103696 startingPage "12493" @default.
- W1969103696 abstract "Matrix metalloprotease type 9 (MMP-9) has been functionally implicated in VEGF activation, the induction and maintenance of chronic angiogenesis, and early stage tumor growth in a number of mouse models of cancer. In this article, we have identified two inflammatory cell types that are major sources of MMP-9 in the angiogenic stages of pancreatic islet carcinogenesis that unfold in RIP1-Tag2 transgenic mice. MMP-9-expressing neutrophils were predominantly found inside angiogenic islet dysplasias and tumors, whereas MMP-9-expressing macrophages were localized along the periphery of such lesions. Transient depletion of neutrophils significantly suppressed VEGF:VEGF-receptor association, a signature of MMP-9 activity, and markedly reduced the frequency of initial angiogenic switching in dysplasias. Thus infiltrating neutrophils can play a crucial role in activating angiogenesis in a previously quiescent tissue vasculature during the early stages of carcinogenesis." @default.
- W1969103696 created "2016-06-24" @default.
- W1969103696 creator A5007537368 @default.
- W1969103696 creator A5066247828 @default.
- W1969103696 creator A5089842877 @default.
- W1969103696 date "2006-08-15" @default.
- W1969103696 modified "2023-10-16" @default.
- W1969103696 title "Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis" @default.
- W1969103696 cites W1480357432 @default.
- W1969103696 cites W1518549789 @default.
- W1969103696 cites W1574172480 @default.
- W1969103696 cites W1965037168 @default.
- W1969103696 cites W1977999028 @default.
- W1969103696 cites W1980584100 @default.
- W1969103696 cites W1985528986 @default.
- W1969103696 cites W1985804036 @default.
- W1969103696 cites W1993677761 @default.
- W1969103696 cites W1994003134 @default.
- W1969103696 cites W1999903411 @default.
- W1969103696 cites W2001717792 @default.
- W1969103696 cites W2006673918 @default.
- W1969103696 cites W2015809080 @default.
- W1969103696 cites W2019214729 @default.
- W1969103696 cites W2021268612 @default.
- W1969103696 cites W2022512688 @default.
- W1969103696 cites W2034464608 @default.
- W1969103696 cites W206141176 @default.
- W1969103696 cites W2068360183 @default.
- W1969103696 cites W2071507111 @default.
- W1969103696 cites W2080040601 @default.
- W1969103696 cites W2088601895 @default.
- W1969103696 cites W2089723533 @default.
- W1969103696 cites W2097619603 @default.
- W1969103696 cites W2107370389 @default.
- W1969103696 cites W2109065012 @default.
- W1969103696 cites W2114444869 @default.
- W1969103696 cites W2126435004 @default.
- W1969103696 cites W2130927569 @default.
- W1969103696 cites W2146440075 @default.
- W1969103696 cites W2148976175 @default.
- W1969103696 cites W2149142217 @default.
- W1969103696 cites W2150220637 @default.
- W1969103696 cites W2158739925 @default.
- W1969103696 cites W2165362420 @default.
- W1969103696 cites W2169579591 @default.
- W1969103696 cites W2170095111 @default.
- W1969103696 cites W2411869533 @default.
- W1969103696 cites W4251795098 @default.
- W1969103696 doi "https://doi.org/10.1073/pnas.0601807103" @default.
- W1969103696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1531646" @default.
- W1969103696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16891410" @default.
- W1969103696 hasPublicationYear "2006" @default.
- W1969103696 type Work @default.
- W1969103696 sameAs 1969103696 @default.
- W1969103696 citedByCount "778" @default.
- W1969103696 countsByYear W19691036962012 @default.
- W1969103696 countsByYear W19691036962013 @default.
- W1969103696 countsByYear W19691036962014 @default.
- W1969103696 countsByYear W19691036962015 @default.
- W1969103696 countsByYear W19691036962016 @default.
- W1969103696 countsByYear W19691036962017 @default.
- W1969103696 countsByYear W19691036962018 @default.
- W1969103696 countsByYear W19691036962019 @default.
- W1969103696 countsByYear W19691036962020 @default.
- W1969103696 countsByYear W19691036962021 @default.
- W1969103696 countsByYear W19691036962022 @default.
- W1969103696 countsByYear W19691036962023 @default.
- W1969103696 crossrefType "journal-article" @default.
- W1969103696 hasAuthorship W1969103696A5007537368 @default.
- W1969103696 hasAuthorship W1969103696A5066247828 @default.
- W1969103696 hasAuthorship W1969103696A5089842877 @default.
- W1969103696 hasBestOaLocation W19691036961 @default.
- W1969103696 hasConcept C102230213 @default.
- W1969103696 hasConcept C104317684 @default.
- W1969103696 hasConcept C109523444 @default.
- W1969103696 hasConcept C121608353 @default.
- W1969103696 hasConcept C134018914 @default.
- W1969103696 hasConcept C141035611 @default.
- W1969103696 hasConcept C142724271 @default.
- W1969103696 hasConcept C165220095 @default.
- W1969103696 hasConcept C2778271429 @default.
- W1969103696 hasConcept C2779306644 @default.
- W1969103696 hasConcept C2780394083 @default.
- W1969103696 hasConcept C502942594 @default.
- W1969103696 hasConcept C54355233 @default.
- W1969103696 hasConcept C55493867 @default.
- W1969103696 hasConcept C555283112 @default.
- W1969103696 hasConcept C71924100 @default.
- W1969103696 hasConcept C86803240 @default.
- W1969103696 hasConceptScore W1969103696C102230213 @default.
- W1969103696 hasConceptScore W1969103696C104317684 @default.
- W1969103696 hasConceptScore W1969103696C109523444 @default.
- W1969103696 hasConceptScore W1969103696C121608353 @default.
- W1969103696 hasConceptScore W1969103696C134018914 @default.
- W1969103696 hasConceptScore W1969103696C141035611 @default.
- W1969103696 hasConceptScore W1969103696C142724271 @default.
- W1969103696 hasConceptScore W1969103696C165220095 @default.
- W1969103696 hasConceptScore W1969103696C2778271429 @default.