FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969130182> ?p ?o ?g. }

• W1969130182 endingPage "94" @default.
• W1969130182 startingPage "89" @default.
• W1969130182 abstract "Background: The circulating DNA in plasma/serum of cancer patients has been shown to reflect the characteristics of the tumor DNA including molecular changes, such as methylation, point mutations and microsatellite instability. Fragmented nucleosomal DNA in plasma resulting from apoptotic death of the tumor cells may also provide an indication for tumor DNA. In this study, we comparatively analysed plasma DNA methylation and presence of fragmented nucleosomal DNA in patients with lymphoproliferative diseases. Methods: Methylation in the first exon of the tumor supressor gene p16 was investigated by the methylation-sensitive restriction enzyme-related PCR. DNA fragmentation in plasma was analysed by gel electrophoresis. Results: p16 gene methylation was found to occur in 73% of patients but in none of the 20 healthy controls. Nucleosomal DNA fragmentation was detectable in 81% of patients. In 67% of patients, copresence of both parameters was observed. Presence of both parameters was associated with the stage of disease which was more pronounced for nucleosomal DNA fragmentation. Conclusions: Our results suggest that presence of methylated and apoptotic DNA in plasma of patients with lymphoproliferative diseases is a frequent event and may be used as a marker for early diagnosis and during the follow-up of the disease." @default.
• W1969130182 created "2016-06-24" @default.
• W1969130182 creator A5039253565 @default.
• W1969130182 creator A5068453439 @default.
• W1969130182 creator A5078350683 @default.
• W1969130182 creator A5088071332 @default.
• W1969130182 date "2003-09-01" @default.
• W1969130182 modified "2023-09-25" @default.
• W1969130182 title "Frequent copresence of methylated DNA and fragmented nucleosomal DNA in plasma of lymphoma patients" @default.
• W1969130182 cites W1249058925 @default.
• W1969130182 cites W1538895448 @default.
• W1969130182 cites W1777679887 @default.
• W1969130182 cites W1983348452 @default.
• W1969130182 cites W1994926857 @default.
• W1969130182 cites W2003108269 @default.
• W1969130182 cites W2020716585 @default.
• W1969130182 cites W2067234934 @default.
• W1969130182 cites W2073327124 @default.
• W1969130182 cites W2085324779 @default.
• W1969130182 cites W2095728717 @default.
• W1969130182 cites W2105528893 @default.
• W1969130182 cites W2950922368 @default.
• W1969130182 cites W337574275 @default.
• W1969130182 cites W4255476264 @default.
• W1969130182 cites W4377086376 @default.
• W1969130182 doi "https://doi.org/10.1016/s0009-8981(03)00279-1" @default.
• W1969130182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12927689" @default.
• W1969130182 hasPublicationYear "2003" @default.
• W1969130182 type Work @default.
• W1969130182 sameAs 1969130182 @default.
• W1969130182 citedByCount "39" @default.
• W1969130182 countsByYear W19691301822012 @default.
• W1969130182 countsByYear W19691301822013 @default.
• W1969130182 countsByYear W19691301822014 @default.
• W1969130182 countsByYear W19691301822015 @default.
• W1969130182 countsByYear W19691301822016 @default.
• W1969130182 countsByYear W19691301822017 @default.
• W1969130182 countsByYear W19691301822018 @default.
• W1969130182 countsByYear W19691301822020 @default.
• W1969130182 countsByYear W19691301822021 @default.
• W1969130182 countsByYear W19691301822022 @default.
• W1969130182 countsByYear W19691301822023 @default.
• W1969130182 crossrefType "journal-article" @default.
• W1969130182 hasAuthorship W1969130182A5039253565 @default.
• W1969130182 hasAuthorship W1969130182A5068453439 @default.
• W1969130182 hasAuthorship W1969130182A5078350683 @default.
• W1969130182 hasAuthorship W1969130182A5088071332 @default.
• W1969130182 hasConcept C104317684 @default.
• W1969130182 hasConcept C150194340 @default.
• W1969130182 hasConcept C153911025 @default.
• W1969130182 hasConcept C180754005 @default.
• W1969130182 hasConcept C18903297 @default.
• W1969130182 hasConcept C190283241 @default.
• W1969130182 hasConcept C190727270 @default.
• W1969130182 hasConcept C191015642 @default.
• W1969130182 hasConcept C2779767149 @default.
• W1969130182 hasConcept C31573885 @default.
• W1969130182 hasConcept C43759708 @default.
• W1969130182 hasConcept C502942594 @default.
• W1969130182 hasConcept C54355233 @default.
• W1969130182 hasConcept C552990157 @default.
• W1969130182 hasConcept C61320498 @default.
• W1969130182 hasConcept C86803240 @default.
• W1969130182 hasConceptScore W1969130182C104317684 @default.
• W1969130182 hasConceptScore W1969130182C150194340 @default.
• W1969130182 hasConceptScore W1969130182C153911025 @default.
• W1969130182 hasConceptScore W1969130182C180754005 @default.
• W1969130182 hasConceptScore W1969130182C18903297 @default.
• W1969130182 hasConceptScore W1969130182C190283241 @default.
• W1969130182 hasConceptScore W1969130182C190727270 @default.
• W1969130182 hasConceptScore W1969130182C191015642 @default.
• W1969130182 hasConceptScore W1969130182C2779767149 @default.
• W1969130182 hasConceptScore W1969130182C31573885 @default.
• W1969130182 hasConceptScore W1969130182C43759708 @default.
• W1969130182 hasConceptScore W1969130182C502942594 @default.
• W1969130182 hasConceptScore W1969130182C54355233 @default.
• W1969130182 hasConceptScore W1969130182C552990157 @default.
• W1969130182 hasConceptScore W1969130182C61320498 @default.
• W1969130182 hasConceptScore W1969130182C86803240 @default.
• W1969130182 hasIssue "1-2" @default.
• W1969130182 hasLocation W19691301821 @default.
• W1969130182 hasLocation W19691301822 @default.
• W1969130182 hasOpenAccess W1969130182 @default.
• W1969130182 hasPrimaryLocation W19691301821 @default.
• W1969130182 hasRelatedWork W150766852 @default.
• W1969130182 hasRelatedWork W1529291209 @default.
• W1969130182 hasRelatedWork W1967568801 @default.
• W1969130182 hasRelatedWork W2016506516 @default.
• W1969130182 hasRelatedWork W2041800645 @default.
• W1969130182 hasRelatedWork W2058131830 @default.
• W1969130182 hasRelatedWork W2067665082 @default.
• W1969130182 hasRelatedWork W2352517883 @default.
• W1969130182 hasRelatedWork W2413150232 @default.
• W1969130182 hasRelatedWork W2473005840 @default.
• W1969130182 hasVolume "335" @default.
• W1969130182 isParatext "false" @default.
• W1969130182 isRetracted "false" @default.
• W1969130182 magId "1969130182" @default.

• next