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• W1969952112 abstract "Hydrophillic minimatrices filled into hard gelatin capsules should be able to disperse and float on the contents of the stomach. However, these floating minitablets exhibit a strong tendency to adhere to one another due to the gelatin capsule shell and to the earlier hydration of the minitablets. Two different procedures were investigated to circumvent this problem: (i) addition of a protective filler excipient into the capsule; and (ii) coating the minitablets. For this latter approach, the type and amount of coating agent and the presence of coating additives were assessed. The degree of dispersion of the minitablets was described using an equation based on the actual area generated by the individual or aggregated minitablets upon contact with the dissolution medium. We demonstrate that it is possible to prevent floating minitablets from aggregating in vitro by using either a protective filler or a polymeric coating insoluble in gastric juice but permeable and swellable." @default.
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• W1969952112 date "1997-04-01" @default.
• W1969952112 modified "2023-10-18" @default.
• W1969952112 title "Prevention of the sticking tendency of floating minitablets filled into hard gelatin capsules" @default.
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• W1969952112 doi "https://doi.org/10.1016/s0939-6411(96)00003-3" @default.
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