FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970367033> ?p ?o ?g. }

• W1970367033 endingPage "582" @default.
• W1970367033 startingPage "571" @default.
• W1970367033 abstract "The transcription factor nuclear factor-kappaB (NF-kappaB) is a key regulator of stress-induced transcriptional activation and has been implicated in mediating primary or acquired apoptosis resistance in various cancers. In the present study, we therefore investigated the role of NF-kappaB in regulating apoptosis in malignant glioma, a prototypic tumor refractory to current treatment approaches. Here, we report that constitutive NF-kappaB DNA-binding activity was low or moderate in eight different glioblastoma cell lines compared to Hodgkin's lymphoma cells, known to harbor aberrant constitutive NF-kappaB activity. Specific inhibition of NF-kappaB by overexpression of inhibitor of kappaB (IkappaB)alpha superrepressor did not enhance spontaneous apoptosis of glioblastoma cells. Also, overexpression of IkappaBalpha superrepressor had no significant impact on apoptosis induced by two prototypic classes of apoptotic stimuli, that is, chemotherapeutic drugs or death-inducing ligands such as TNF-related apoptosis inducing ligand (TRAIL), which are known to trigger NF-kappaB activation as part of a cellular stress response. Similarly, inhibition of NF-kappaB by the proteasome inhibitor MG132 did not increase doxorubicin (Doxo)-induced apoptosis of glioblastoma cells, although it prevented DNA binding of NF-kappaB complexes in response to Doxo. Interestingly, proteasome inhibition significantly sensitized glioblastoma cells for TRAIL-induced apoptosis. These findings indicate that the characteristic antiapoptotic function of NF-kappaB reported for many cancers is not a primary feature of glioblastoma and thus, specific NF-kappaB inhibition may not be effective for chemosensitization of glioblastoma. Instead, proteasome inhibitors, which enhanced TRAIL-induced apoptosis in an NF-kappaB-independent manner, may open new perspectives to increase the efficacy of TRAIL-based regimens in glioblastoma, which warrants further investigation." @default.
• W1970367033 created "2016-06-24" @default.
• W1970367033 creator A5044483462 @default.
• W1970367033 creator A5050645229 @default.
• W1970367033 creator A5055991213 @default.
• W1970367033 creator A5075397312 @default.
• W1970367033 creator A5080479067 @default.
• W1970367033 creator A5080913590 @default.
• W1970367033 creator A5087109583 @default.
• W1970367033 date "2006-08-07" @default.
• W1970367033 modified "2023-09-26" @default.
• W1970367033 title "NF-κB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition" @default.
• W1970367033 cites W1487779062 @default.
• W1970367033 cites W1911504906 @default.
• W1970367033 cites W1975609166 @default.
• W1970367033 cites W1979129905 @default.
• W1970367033 cites W1980480652 @default.
• W1970367033 cites W1992617765 @default.
• W1970367033 cites W2004231706 @default.
• W1970367033 cites W2007456673 @default.
• W1970367033 cites W2013513313 @default.
• W1970367033 cites W2015848531 @default.
• W1970367033 cites W2019405732 @default.
• W1970367033 cites W2026863172 @default.
• W1970367033 cites W2039973219 @default.
• W1970367033 cites W2041173282 @default.
• W1970367033 cites W2043892945 @default.
• W1970367033 cites W2053260674 @default.
• W1970367033 cites W2054273226 @default.
• W1970367033 cites W2055340771 @default.
• W1970367033 cites W2058473971 @default.
• W1970367033 cites W2082575834 @default.
• W1970367033 cites W2084826448 @default.
• W1970367033 cites W2090653170 @default.
• W1970367033 cites W2094646101 @default.
• W1970367033 cites W2095279010 @default.
• W1970367033 cites W2096135828 @default.
• W1970367033 cites W2097010009 @default.
• W1970367033 cites W2098180441 @default.
• W1970367033 cites W2101907617 @default.
• W1970367033 cites W2120116865 @default.
• W1970367033 cites W2136466348 @default.
• W1970367033 cites W2148119611 @default.
• W1970367033 cites W2148588230 @default.
• W1970367033 cites W2323693954 @default.
• W1970367033 cites W2992857549 @default.
• W1970367033 cites W4245243407 @default.
• W1970367033 cites W4293247451 @default.
• W1970367033 doi "https://doi.org/10.1038/sj.onc.1209841" @default.
• W1970367033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16909119" @default.
• W1970367033 hasPublicationYear "2006" @default.
• W1970367033 type Work @default.
• W1970367033 sameAs 1970367033 @default.
• W1970367033 citedByCount "37" @default.
• W1970367033 countsByYear W19703670332012 @default.
• W1970367033 countsByYear W19703670332013 @default.
• W1970367033 countsByYear W19703670332014 @default.
• W1970367033 countsByYear W19703670332015 @default.
• W1970367033 countsByYear W19703670332016 @default.
• W1970367033 countsByYear W19703670332019 @default.
• W1970367033 countsByYear W19703670332021 @default.
• W1970367033 countsByYear W19703670332022 @default.
• W1970367033 crossrefType "journal-article" @default.
• W1970367033 hasAuthorship W1970367033A5044483462 @default.
• W1970367033 hasAuthorship W1970367033A5050645229 @default.
• W1970367033 hasAuthorship W1970367033A5055991213 @default.
• W1970367033 hasAuthorship W1970367033A5075397312 @default.
• W1970367033 hasAuthorship W1970367033A5080479067 @default.
• W1970367033 hasAuthorship W1970367033A5080913590 @default.
• W1970367033 hasAuthorship W1970367033A5087109583 @default.
• W1970367033 hasBestOaLocation W19703670331 @default.
• W1970367033 hasConcept C143425029 @default.
• W1970367033 hasConcept C190283241 @default.
• W1970367033 hasConcept C27740335 @default.
• W1970367033 hasConcept C2777408456 @default.
• W1970367033 hasConcept C2777730290 @default.
• W1970367033 hasConcept C2778367456 @default.
• W1970367033 hasConcept C2778506107 @default.
• W1970367033 hasConcept C31573885 @default.
• W1970367033 hasConcept C502942594 @default.
• W1970367033 hasConcept C54355233 @default.
• W1970367033 hasConcept C552990157 @default.
• W1970367033 hasConcept C55493867 @default.
• W1970367033 hasConcept C81885089 @default.
• W1970367033 hasConcept C86803240 @default.
• W1970367033 hasConcept C95444343 @default.
• W1970367033 hasConceptScore W1970367033C143425029 @default.
• W1970367033 hasConceptScore W1970367033C190283241 @default.
• W1970367033 hasConceptScore W1970367033C27740335 @default.
• W1970367033 hasConceptScore W1970367033C2777408456 @default.
• W1970367033 hasConceptScore W1970367033C2777730290 @default.
• W1970367033 hasConceptScore W1970367033C2778367456 @default.
• W1970367033 hasConceptScore W1970367033C2778506107 @default.
• W1970367033 hasConceptScore W1970367033C31573885 @default.
• W1970367033 hasConceptScore W1970367033C502942594 @default.
• W1970367033 hasConceptScore W1970367033C54355233 @default.
• W1970367033 hasConceptScore W1970367033C552990157 @default.
• W1970367033 hasConceptScore W1970367033C55493867 @default.

• next