Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970889097> ?p ?o ?g. }
- W1970889097 endingPage "278" @default.
- W1970889097 startingPage "272" @default.
- W1970889097 abstract "To establish whether chondrocytes from normal and osteoarthritic human articular cartilage recognize and respond to pressure induced mechanical strain in a similar manner.Chondrocytes, extracted from macroscopically normal and osteoarthritic human articular cartilage obtained from knee joints at autopsy, were grown in monolayer culture and subjected to cyclical pressure-induced strain (PIS) in the absence or presence of anti-integrin antibodies, agents known to block ion channels and inhibitors of key molecules involved in the integrin-associated signalling pathways. The response of the cells to mechanical stimulation was assessed by measuring changes in membrane potential.Unlike chondrocytes from normal articular cartilage, which showed a membrane hyperpolarization response to PIS, chondrocytes from osteoarthritic cartilage responded by membrane depolarization. The mechanotransduction pathway involves alpha5beta1 integrins, stretch-activated ion channels, tyrosine kinases and phospholipase C but the actin cytoskeleton and protein kinase C, which are important in the membrane hyperpolarization response in normal chondrocytes, are not necessary for membrane depolarization in osteoarthritic chondrocytes in response to PIS.Chondrocytes derived from osteoarthritic cartilage show a different signalling pathway via alpha5beta1 integrin in response to mechanical stimulation which may be of importance in the production of phenotypic changes recognized to be present in diseased cartilage." @default.
- W1970889097 created "2016-06-24" @default.
- W1970889097 creator A5000966945 @default.
- W1970889097 creator A5024434387 @default.
- W1970889097 creator A5037573724 @default.
- W1970889097 creator A5039338150 @default.
- W1970889097 creator A5059459855 @default.
- W1970889097 creator A5069566006 @default.
- W1970889097 date "2000-07-01" @default.
- W1970889097 modified "2023-09-26" @default.
- W1970889097 title "Altered electrophysiological responses to mechanical stimulation and abnormal signalling through α5β1 integrin in chondrocytes from osteoarthritic cartilage" @default.
- W1970889097 cites W1480719130 @default.
- W1970889097 cites W1589866689 @default.
- W1970889097 cites W1656644300 @default.
- W1970889097 cites W1841826782 @default.
- W1970889097 cites W1963498248 @default.
- W1970889097 cites W1968473165 @default.
- W1970889097 cites W1973454785 @default.
- W1970889097 cites W1979856671 @default.
- W1970889097 cites W1986887981 @default.
- W1970889097 cites W1999770057 @default.
- W1970889097 cites W2002399228 @default.
- W1970889097 cites W2006435282 @default.
- W1970889097 cites W2008990874 @default.
- W1970889097 cites W2014471803 @default.
- W1970889097 cites W2027735391 @default.
- W1970889097 cites W2042045265 @default.
- W1970889097 cites W2042117411 @default.
- W1970889097 cites W2051039353 @default.
- W1970889097 cites W2051942714 @default.
- W1970889097 cites W2052766715 @default.
- W1970889097 cites W2056968498 @default.
- W1970889097 cites W2059842158 @default.
- W1970889097 cites W2060768476 @default.
- W1970889097 cites W2062676485 @default.
- W1970889097 cites W2069119615 @default.
- W1970889097 cites W2075473225 @default.
- W1970889097 cites W2079357592 @default.
- W1970889097 cites W2084017530 @default.
- W1970889097 cites W2085330804 @default.
- W1970889097 cites W2092868973 @default.
- W1970889097 cites W2093113620 @default.
- W1970889097 cites W2093509637 @default.
- W1970889097 cites W2105765718 @default.
- W1970889097 cites W2106331230 @default.
- W1970889097 cites W2148713236 @default.
- W1970889097 cites W2159542600 @default.
- W1970889097 cites W2163304270 @default.
- W1970889097 cites W2163431321 @default.
- W1970889097 cites W2170174359 @default.
- W1970889097 cites W2186680027 @default.
- W1970889097 cites W2416387298 @default.
- W1970889097 cites W4234485916 @default.
- W1970889097 doi "https://doi.org/10.1053/joca.1999.0301" @default.
- W1970889097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10903881" @default.
- W1970889097 hasPublicationYear "2000" @default.
- W1970889097 type Work @default.
- W1970889097 sameAs 1970889097 @default.
- W1970889097 citedByCount "87" @default.
- W1970889097 countsByYear W19708890972012 @default.
- W1970889097 countsByYear W19708890972013 @default.
- W1970889097 countsByYear W19708890972014 @default.
- W1970889097 countsByYear W19708890972015 @default.
- W1970889097 countsByYear W19708890972017 @default.
- W1970889097 countsByYear W19708890972018 @default.
- W1970889097 countsByYear W19708890972019 @default.
- W1970889097 countsByYear W19708890972020 @default.
- W1970889097 countsByYear W19708890972021 @default.
- W1970889097 countsByYear W19708890972022 @default.
- W1970889097 countsByYear W19708890972023 @default.
- W1970889097 crossrefType "journal-article" @default.
- W1970889097 hasAuthorship W1970889097A5000966945 @default.
- W1970889097 hasAuthorship W1970889097A5024434387 @default.
- W1970889097 hasAuthorship W1970889097A5037573724 @default.
- W1970889097 hasAuthorship W1970889097A5039338150 @default.
- W1970889097 hasAuthorship W1970889097A5059459855 @default.
- W1970889097 hasAuthorship W1970889097A5069566006 @default.
- W1970889097 hasBestOaLocation W19708890971 @default.
- W1970889097 hasConcept C105702510 @default.
- W1970889097 hasConcept C134018914 @default.
- W1970889097 hasConcept C142724271 @default.
- W1970889097 hasConcept C170493617 @default.
- W1970889097 hasConcept C181104049 @default.
- W1970889097 hasConcept C185592680 @default.
- W1970889097 hasConcept C195687474 @default.
- W1970889097 hasConcept C204787440 @default.
- W1970889097 hasConcept C25515809 @default.
- W1970889097 hasConcept C2776164576 @default.
- W1970889097 hasConcept C2780550940 @default.
- W1970889097 hasConcept C4141045 @default.
- W1970889097 hasConcept C55493867 @default.
- W1970889097 hasConcept C71924100 @default.
- W1970889097 hasConcept C86803240 @default.
- W1970889097 hasConcept C95444343 @default.
- W1970889097 hasConceptScore W1970889097C105702510 @default.
- W1970889097 hasConceptScore W1970889097C134018914 @default.
- W1970889097 hasConceptScore W1970889097C142724271 @default.
- W1970889097 hasConceptScore W1970889097C170493617 @default.