Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971036388> ?p ?o ?g. }
- W1971036388 endingPage "e1000207" @default.
- W1971036388 startingPage "e1000207" @default.
- W1971036388 abstract "The early steps of retrovirus replication leading up to provirus establishment are highly dependent on cellular processes and represent a time when the virus is particularly vulnerable to antivirals and host defense mechanisms. However, the roles played by cellular factors are only partially understood. To identify cellular processes that participate in these critical steps, we employed a high volume screening of insertionally mutagenized somatic cells using a murine leukemia virus (MLV) vector. This approach identified a role for 3′-phosphoadenosine 5′-phosphosulfate synthase 1 (PAPSS1), one of two enzymes that synthesize PAPS, the high energy sulfate donor used in all sulfonation reactions catalyzed by cellular sulfotransferases. The role of the cellular sulfonation pathway was confirmed using chemical inhibitors of PAPS synthases and cellular sulfotransferases. The requirement for sulfonation was mapped to a stage during or shortly after MLV provirus establishment and influenced subsequent gene expression from the viral long terminal repeat (LTR) promoter. Infection of cells by an HIV vector was also shown to be highly dependent on the cellular sulfonation pathway. These studies have uncovered a heretofore unknown regulatory step of retroviral replication, have defined a new biological function for sulfonation in nuclear gene expression, and provide a potentially valuable new target for HIV/AIDS therapy." @default.
- W1971036388 created "2016-06-24" @default.
- W1971036388 creator A5005603665 @default.
- W1971036388 creator A5026899432 @default.
- W1971036388 creator A5072970065 @default.
- W1971036388 date "2008-11-14" @default.
- W1971036388 modified "2023-10-16" @default.
- W1971036388 title "The Host Cell Sulfonation Pathway Contributes to Retroviral Infection at a Step Coincident with Provirus Establishment" @default.
- W1971036388 cites W1573554576 @default.
- W1971036388 cites W1603236469 @default.
- W1971036388 cites W1637867377 @default.
- W1971036388 cites W1638608431 @default.
- W1971036388 cites W1640609127 @default.
- W1971036388 cites W1955620128 @default.
- W1971036388 cites W1965813248 @default.
- W1971036388 cites W1966048213 @default.
- W1971036388 cites W1969563526 @default.
- W1971036388 cites W1973779048 @default.
- W1971036388 cites W1980214158 @default.
- W1971036388 cites W1980869599 @default.
- W1971036388 cites W1983644831 @default.
- W1971036388 cites W1986067115 @default.
- W1971036388 cites W1990064965 @default.
- W1971036388 cites W1990428452 @default.
- W1971036388 cites W1996422098 @default.
- W1971036388 cites W1999121501 @default.
- W1971036388 cites W2004893313 @default.
- W1971036388 cites W2006765654 @default.
- W1971036388 cites W2011610089 @default.
- W1971036388 cites W2018797206 @default.
- W1971036388 cites W2019508559 @default.
- W1971036388 cites W2023829232 @default.
- W1971036388 cites W2038070445 @default.
- W1971036388 cites W2040059091 @default.
- W1971036388 cites W2040888123 @default.
- W1971036388 cites W2041795984 @default.
- W1971036388 cites W2043898351 @default.
- W1971036388 cites W2044142593 @default.
- W1971036388 cites W2046156611 @default.
- W1971036388 cites W2048324943 @default.
- W1971036388 cites W2054593921 @default.
- W1971036388 cites W2055697700 @default.
- W1971036388 cites W2057304619 @default.
- W1971036388 cites W2070308395 @default.
- W1971036388 cites W2071817010 @default.
- W1971036388 cites W2072264854 @default.
- W1971036388 cites W2072901265 @default.
- W1971036388 cites W2073273867 @default.
- W1971036388 cites W2080086650 @default.
- W1971036388 cites W2084622547 @default.
- W1971036388 cites W2085489729 @default.
- W1971036388 cites W2088335428 @default.
- W1971036388 cites W2091667727 @default.
- W1971036388 cites W2092664889 @default.
- W1971036388 cites W2092987144 @default.
- W1971036388 cites W2093023493 @default.
- W1971036388 cites W2106494657 @default.
- W1971036388 cites W2109935549 @default.
- W1971036388 cites W2114230362 @default.
- W1971036388 cites W2115259457 @default.
- W1971036388 cites W2118146222 @default.
- W1971036388 cites W2118944608 @default.
- W1971036388 cites W2121100324 @default.
- W1971036388 cites W2122833547 @default.
- W1971036388 cites W2124525990 @default.
- W1971036388 cites W2127707318 @default.
- W1971036388 cites W2127709439 @default.
- W1971036388 cites W2129899421 @default.
- W1971036388 cites W2138015002 @default.
- W1971036388 cites W2139205741 @default.
- W1971036388 cites W2139695852 @default.
- W1971036388 cites W2141427436 @default.
- W1971036388 cites W2145848202 @default.
- W1971036388 cites W2148643489 @default.
- W1971036388 cites W2156432090 @default.
- W1971036388 cites W2158368026 @default.
- W1971036388 cites W2166782710 @default.
- W1971036388 cites W2167832449 @default.
- W1971036388 doi "https://doi.org/10.1371/journal.ppat.1000207" @default.
- W1971036388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2576444" @default.
- W1971036388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19008949" @default.
- W1971036388 hasPublicationYear "2008" @default.
- W1971036388 type Work @default.
- W1971036388 sameAs 1971036388 @default.
- W1971036388 citedByCount "28" @default.
- W1971036388 countsByYear W19710363882012 @default.
- W1971036388 countsByYear W19710363882013 @default.
- W1971036388 countsByYear W19710363882014 @default.
- W1971036388 countsByYear W19710363882016 @default.
- W1971036388 countsByYear W19710363882017 @default.
- W1971036388 countsByYear W19710363882018 @default.
- W1971036388 countsByYear W19710363882019 @default.
- W1971036388 countsByYear W19710363882021 @default.
- W1971036388 countsByYear W19710363882023 @default.
- W1971036388 crossrefType "journal-article" @default.
- W1971036388 hasAuthorship W1971036388A5005603665 @default.
- W1971036388 hasAuthorship W1971036388A5026899432 @default.
- W1971036388 hasAuthorship W1971036388A5072970065 @default.