Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971963669> ?p ?o ?g. }
- W1971963669 endingPage "241" @default.
- W1971963669 startingPage "232" @default.
- W1971963669 abstract "Developmental organophosphate exposure reduces the numbers of neural cells, contributing to neurobehavioral deficits. We administered chlorpyrifos or diazinon to newborn rats on postnatal days 1-4, in doses straddling the threshold for barely-detectable cholinesterase inhibition, and evaluated gene expression in the cell cycle and apoptosis pathways on postnatal day 5. Both organophosphates evoked transcriptional changes in 20-25% of the genes in each category; chlorpyrifos and diazinon targeted the same genes, with similar magnitudes of change, as evidenced by high concordance. Furthermore, the same effects were obtained with doses above or below the threshold for cholinesterase inhibition, indicating a mechanism unrelated to anticholinesterase actions. We then evaluated the effects of chlorpyrifos in undifferentiated and differentiating PC12 cells and found even greater targeting of cell cycle and apoptosis genes, affecting up to 40% of all genes in the pathways. Notably, the genes affected in undifferentiated cells were not concordant with those in differentiating cells, pointing to dissimilar outcomes dependent on developmental stage. The in vitro model successfully identified 60-70% of the genes affected by chlorpyrifos in vivo, indicating that the effects are exerted directly on developing neural cells. Our results show that organophosphates target the genes regulating the cell cycle and apoptosis in the developing brain and in neuronotypic cells in culture, with the pattern of vulnerability dependent on the specific stage of development. Equally important, these effects do not reflect actions on cholinesterase and operate at exposures below the threshold for any detectable inhibition of this enzyme." @default.
- W1971963669 created "2016-06-24" @default.
- W1971963669 creator A5000464378 @default.
- W1971963669 creator A5038298482 @default.
- W1971963669 date "2012-03-01" @default.
- W1971963669 modified "2023-10-16" @default.
- W1971963669 title "Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro" @default.
- W1971963669 cites W1508349309 @default.
- W1971963669 cites W1584636459 @default.
- W1971963669 cites W1842749771 @default.
- W1971963669 cites W1966527651 @default.
- W1971963669 cites W1968910122 @default.
- W1971963669 cites W1971955600 @default.
- W1971963669 cites W1973415720 @default.
- W1971963669 cites W1974791181 @default.
- W1971963669 cites W1976298317 @default.
- W1971963669 cites W1983603356 @default.
- W1971963669 cites W1986745486 @default.
- W1971963669 cites W1991886909 @default.
- W1971963669 cites W1996111288 @default.
- W1971963669 cites W2006829255 @default.
- W1971963669 cites W2014216862 @default.
- W1971963669 cites W2018037495 @default.
- W1971963669 cites W2023235364 @default.
- W1971963669 cites W2030842083 @default.
- W1971963669 cites W2031398528 @default.
- W1971963669 cites W2032624996 @default.
- W1971963669 cites W2033555216 @default.
- W1971963669 cites W2037844649 @default.
- W1971963669 cites W2041383091 @default.
- W1971963669 cites W2042859546 @default.
- W1971963669 cites W2048375274 @default.
- W1971963669 cites W2049721656 @default.
- W1971963669 cites W2054636717 @default.
- W1971963669 cites W2055844265 @default.
- W1971963669 cites W2062175141 @default.
- W1971963669 cites W2065289459 @default.
- W1971963669 cites W2066253693 @default.
- W1971963669 cites W2067581409 @default.
- W1971963669 cites W2067715785 @default.
- W1971963669 cites W2073889665 @default.
- W1971963669 cites W2075532739 @default.
- W1971963669 cites W2080763813 @default.
- W1971963669 cites W2092104311 @default.
- W1971963669 cites W2095433441 @default.
- W1971963669 cites W2103017472 @default.
- W1971963669 cites W2132781112 @default.
- W1971963669 cites W2165570695 @default.
- W1971963669 cites W2167553705 @default.
- W1971963669 doi "https://doi.org/10.1016/j.ntt.2011.12.001" @default.
- W1971963669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3303931" @default.
- W1971963669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22222554" @default.
- W1971963669 hasPublicationYear "2012" @default.
- W1971963669 type Work @default.
- W1971963669 sameAs 1971963669 @default.
- W1971963669 citedByCount "52" @default.
- W1971963669 countsByYear W19719636692012 @default.
- W1971963669 countsByYear W19719636692013 @default.
- W1971963669 countsByYear W19719636692014 @default.
- W1971963669 countsByYear W19719636692015 @default.
- W1971963669 countsByYear W19719636692016 @default.
- W1971963669 countsByYear W19719636692017 @default.
- W1971963669 countsByYear W19719636692018 @default.
- W1971963669 countsByYear W19719636692019 @default.
- W1971963669 countsByYear W19719636692020 @default.
- W1971963669 countsByYear W19719636692021 @default.
- W1971963669 countsByYear W19719636692023 @default.
- W1971963669 crossrefType "journal-article" @default.
- W1971963669 hasAuthorship W1971963669A5000464378 @default.
- W1971963669 hasAuthorship W1971963669A5038298482 @default.
- W1971963669 hasBestOaLocation W19719636692 @default.
- W1971963669 hasConcept C126322002 @default.
- W1971963669 hasConcept C161176658 @default.
- W1971963669 hasConcept C181199279 @default.
- W1971963669 hasConcept C190283241 @default.
- W1971963669 hasConcept C207001950 @default.
- W1971963669 hasConcept C2776304672 @default.
- W1971963669 hasConcept C2776588719 @default.
- W1971963669 hasConcept C2778816929 @default.
- W1971963669 hasConcept C2779491297 @default.
- W1971963669 hasConcept C2779842916 @default.
- W1971963669 hasConcept C29537977 @default.
- W1971963669 hasConcept C29730261 @default.
- W1971963669 hasConcept C31896038 @default.
- W1971963669 hasConcept C54355233 @default.
- W1971963669 hasConcept C55493867 @default.
- W1971963669 hasConcept C6557445 @default.
- W1971963669 hasConcept C71924100 @default.
- W1971963669 hasConcept C86803240 @default.
- W1971963669 hasConcept C95444343 @default.
- W1971963669 hasConcept C98274493 @default.
- W1971963669 hasConceptScore W1971963669C126322002 @default.
- W1971963669 hasConceptScore W1971963669C161176658 @default.
- W1971963669 hasConceptScore W1971963669C181199279 @default.
- W1971963669 hasConceptScore W1971963669C190283241 @default.
- W1971963669 hasConceptScore W1971963669C207001950 @default.
- W1971963669 hasConceptScore W1971963669C2776304672 @default.
- W1971963669 hasConceptScore W1971963669C2776588719 @default.