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• W1972288897 abstract "We report that specific binding of ligand-functionalized (biotinylated) phospholipid vesicles (diameter = 120 ± 19 nm) to a monolayer of proteins (streptavidin or anti-biotin antibody) adsorbed at an interface between an aqueous phase and an immiscible film of a thermotropic liquid crystal (LC) [nematic 4'-pentyl-4-cyanobiphenyl (5CB)] triggers a continuous orientational ordering transition (continuous change in the tilt) in the LC. Results presented in this paper indicate that, following the capture of the vesicles at the LC interface via the specific binding interaction, phospholipids are transferred from the vesicles onto the LC interface to form a monolayer, reorganizing and partially displacing proteins from the LC interface. The dynamics of this process are accelerated substantially by the specific binding event relative to a protein-decorated interface of a LC that does not bind the ligands presented by the vesicles. The observation of the continuous change in the ordering of the LC, when combined with other results presented in this paper, is significant, as it is consistent with the presence of suboptical domains of proteins and phospholipids on the LC interface. An additional significant hypothesis that emerges from the work reported in this paper is that the ordering transition of the LC is strongly influenced by the bound state of the protein adsorbed on the LC interface, as evidenced by the influence on the LC of (i) crowding of the protein within a monolayer formed at the LC interface and (ii) aging of the proteins on the LC interface. Overall, these results demonstrate that ordering transitions in LCs can be used to provide fundamental insights into the competitive adsorption of proteins and lipids at oil-water interfaces and that LC ordering transitions have the potential to be useful for reporting specific binding events involving vesicles and proteins." @default.
• W1972288897 created "2016-06-24" @default.
• W1972288897 creator A5005376821 @default.
• W1972288897 creator A5014198121 @default.
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• W1972288897 date "2012-04-03" @default.
• W1972288897 modified "2023-10-14" @default.
• W1972288897 title "Ordering Transitions Triggered by Specific Binding of Vesicles to Protein-Decorated Interfaces of Thermotropic Liquid Crystals" @default.
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• W1972288897 doi "https://doi.org/10.1021/la300108f" @default.
• W1972288897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3359374" @default.
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