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- W1974241000 abstract "Stroke is one of the main causes of death and adult chronic disability. Recently, 2 independent genome-wide association studies reported that the genetic variants (rs556621 and rs11984041) are significantly associated with large artery atherosclerosis (LAA).To determine whether these 2 variants are associated with the pathogenesis of LAA in stroke patients from the Xinjiang Uyghur autonomous region of China, both variants were evaluated in a series of 733 LAA stroke patients (434 Han and 299 Uyghur) and 725 age-, gender-, smoking-, alcohol habits- and ethnicity-matched controls (401 Han and 324 Uyghur).For rs556621, significant differences in genotypic and allelic distributions were observed between Uyghur patients and controls (P = .045 for genotypic distribution, P = .042 for allelic distribution) but not in the Chinese Han cohort (P > .05). No significant differences were found in genotypic and allele distributions between patients and controls for rs11984041 in either the Chinese Han or Uyghur cohort (P > .05).The variant rs556621 but not rs11984041 may increase susceptibility of LAA stroke in the Xinjiang Uyghur population." @default.
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- W1974241000 date "2014-11-01" @default.
- W1974241000 modified "2023-09-30" @default.
- W1974241000 title "Gene Polymorphism of rs556621 but Not rs11984041 is Associated with the Risk of Large Artery Atherosclerotic Stroke in a Xinjiang Uyghur Population" @default.
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- W1974241000 doi "https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.06.015" @default.
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