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• W1976217984 endingPage "79" @default.
• W1976217984 startingPage "70" @default.
• W1976217984 abstract "Oocyte maturation (OM) is initiated in lower vertebrates and echinoderms when maturation-inducing substances (MIS) bind oocyte membrane receptors. This study tested the hypothesis that activation of a Gi protein is necessary for MIS-mediated OM in spotted seatrout. Addition of MIS significantly decreased adenylyl cyclase activity in a steroid specific, pertussis toxin (PTX)-sensitive manner in oocyte membranes and microinjection of PTX into oocytes inhibited MIS-induced OM, suggesting the steroid activates a Gi protein. MIS significantly increased [35S]GTPγS binding to ovarian membranes, confirming that MIS receptor binding activates a G-protein, and immunoprecipitation studies showed the increased [35S]GTPγS binding was associated with Gαi1-3 proteins. Radioligand binding studies in ovarian membranes using GTPγS and PTX demonstrated that the MIS binds a receptor coupled to a PTX-sensitive G-protein. This study provides the first direct evidence in a vertebrate model that MIS-induced activation of a Gi protein is necessary for OM. These results support a mechanism of MIS action involving binding to a novel, G-protein coupled receptor and activation of an inhibitory G-protein, the most comprehensive and plausible model of MIS initiation of OM proposed to date." @default.
• W1976217984 created "2016-06-24" @default.
• W1976217984 creator A5029049466 @default.
• W1976217984 creator A5044133296 @default.
• W1976217984 date "2005-09-01" @default.
• W1976217984 modified "2023-09-25" @default.
• W1976217984 title "Activation of a pertussis toxin-sensitive, inhibitory G-protein is necessary for steroid-mediated oocyte maturation in spotted seatrout" @default.
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• W1976217984 doi "https://doi.org/10.1016/j.ydbio.2005.06.003" @default.
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