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• W1977367068 abstract "The acute toxicity of diphenyldiselenide (DPDS) in the male Swiss mouse was found to be enhanced by pretreatment with phenobarbital of SKF-525A. DPDS decreased hepatic glutathione content by 50% at 1 h after administration. Following administration of 14C-DPDS, labelled metabolites were found in urine but not in bile or feces. Analysis of the urinary metabolites of 14C-DPDS showed that selenium-containing metabolites elute from a DEAE-Sephadex column in two fractions: the first has not been chemically characterized, while the second peak contained the glucuronide conjugates of C6H4(OH)SeH and C6H5SeH. Virtually all of the administered selenium is excreted within 5 days, while only about 36% of the 14C is exercted in the same time period. This discrepancy indicates metabolic scission of the carbon selenium bond." @default.
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• W1977367068 date "1989-09-01" @default.
• W1977367068 modified "2023-09-24" @default.
• W1977367068 title "Acute toxicity and urinary excretion of diphenyldiselenide" @default.
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• W1977367068 doi "https://doi.org/10.1016/0378-4274(89)90057-x" @default.
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