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• W1977688889 abstract "It has been reported that wild-type APC protein forms a complex with β-Catenin and GSK3β, inducing degradation of β-Catenin in normal cells. Both β-Catenin and APC gene mutations have recently been shown to activate the same signaling pathway. Frequent mutations of β-Catenin in hereditary nonpolyposis colorectal carcinomas have also been reported. It was, however, controversial whether the mutation of the β-Catenin gene was frequent in nonfamilial colorectal carcinomas with high-frequency microsatellite instability (MSI-H). We analyzed the mutations of the APC and β-Catenin genes in 56 nonfamilial colorectal carcinomas stratified according to the presence or absence of microsatellite instability (MSI). APC mutations were identified in 11 of 22 (50%) cases of MSI-H and 14 of 34 (41%) cases of microsatellite-stable (MSS)/low-frequency microsatellite instability (MSI-L). In contrast, the frequency of β-Catenin mutations was significantly higher in MSI-H (6/22; 27%) than in MSS/MSI-L (1/34; 3%) (P = 0.01). β-Catenin mutations were not detected in carcinomas with APC mutation. APC mutation occurred irrespective of MSI status. β-Catenin mutation, however, occurred frequently in MSI-H carcinomas. Our data suggest that activation of the β-Catenin-Tcf signaling pathway, through either β-Catenin or APC mutation, frequently contributes to MSI-H nonfamilial colorectal carcinomas (17/22; 77%). © 2000 Wiley-Liss, Inc." @default.
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• W1977688889 date "2000-01-01" @default.
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• W1977688889 title "Frequent activation of the ?-catenin-Tcf signaling pathway in nonfamilial colorectal carcinomas with microsatellite instability" @default.
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• W1977688889 doi "https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1065>3.0.co;2-i" @default.
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