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• W1979471150 abstract "Summary 1 The present study investigated the effect of streptozotocin‐induced diabetes on α 1 ‐adrenoceptor subtypes in rat renal resistance vessels. 2 Studies on renal haemodynamics were carried out 7 days after the last streptozotocin. Changes in renal blood flow were recorded in response to electrical stimulation of the renal nerve (RNS) and a range of adrenergic agonists; noradrenaline (NA), phenylephrine (PE) and methoxamine (MTX), either in the absence or the presence of nitrendipine (Nit), 5‐methylurapidil (MEU), chlorethylclonidine (CEC) or BMY 7378. 3 In non‐diabetic animals, Nit, MEU and BMY 7378 significantly attenuated renal vasoconstriction induced by adrenergic agonists, while CEC showed a significant accentuation in RNS‐induced responses without having a significant effect on responses to adrenergic agonists. In diabetic rats, renal vasoconstriction was also significantly reduced in Nit‐, MEU‐ and BMY 7378‐treated groups and CEC potentiated RNS‐induced contractions caused a change similar to that observed in non‐diabetic rats. BMY 7378 significantly ( P < 0.05) attenuated the PE‐ and MTX‐induced vasoconstrictions but did not cause any significant ( P > 0.05) alteration in the RNS‐ and NA‐induced responses. 4 The results showed functional co‐existence of α 1A ‐ and α 1D ‐adrenoceptors in the renal vasculature of SD rats irrespective of the presence of diabetes. A possible minor contribution of prejunctional α‐adrenoceptor subtype has also been suggested in either experimental group, particularly possible functional involvement of α 1B ‐adrenoceptor subtypes in non‐diabetic SD rats." @default.
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• W1979471150 date "2008-01-01" @default.
• W1979471150 modified "2023-10-18" @default.
• W1979471150 title "α_1A- and α_1D-adrenoceptors are the major functional subtypes of renal α₁-adrenoceptors in streptozotocin-induced diabetic and normal Sprague–Dawley rats" @default.
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• W1979471150 doi "https://doi.org/10.1111/j.1474-8673.2007.00412.x" @default.
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