FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979528064> ?p ?o ?g. }

• W1979528064 endingPage "3913" @default.
• W1979528064 startingPage "3908" @default.
• W1979528064 abstract "Scleroderma is a chronic systemic disease that leads to fibrosis of affected organs. Transforming growth factor (TGF) beta has been implicated in the pathogenesis of scleroderma. Smad proteins are signaling transducers downstream from TGF-beta receptors. Three families of Smads have been identified: (i) receptor-regulated Smad2 and -3 (R-Smads); (ii) common partner Smad4 (Co-Smad); and (iii) inhibitory Smad6 and -7 (I-Smads, part of a negative feedback loop). We have investigated the signaling components for the TGF-beta pathway and TGF-beta activity in scleroderma lesions in vivo and in scleroderma fibroblasts in vitro. Basal level and TGF-beta-inducible expression of Smad7 are selectively decreased, whereas Smad3 expression is increased both in scleroderma skin and in explanted scleroderma fibroblasts in culture. TGF-beta signaling events, including phosphorylation of Smad2 and -3, and transcription of the PAI-1 gene are increased in scleroderma fibroblasts, relative to normal fibroblasts. In vitro adenoviral gene transfer with Smad7 restores normal TGF-beta signaling in scleroderma fibroblasts. These results suggest that alterations in the Smad pathway, including marked Smad7 deficiency and Smad3 up-regulation, may be responsible for TGF-beta hyperresponsiveness observed in scleroderma." @default.
• W1979528064 created "2016-06-24" @default.
• W1979528064 creator A5006169846 @default.
• W1979528064 creator A5010548480 @default.
• W1979528064 creator A5018682870 @default.
• W1979528064 creator A5033019353 @default.
• W1979528064 creator A5044432790 @default.
• W1979528064 creator A5046914597 @default.
• W1979528064 creator A5060576956 @default.
• W1979528064 creator A5067962806 @default.
• W1979528064 creator A5068528030 @default.
• W1979528064 creator A5085142676 @default.
• W1979528064 date "2002-03-19" @default.
• W1979528064 modified "2023-10-17" @default.
• W1979528064 title "Deficient Smad7 expression: A putative molecular defect in scleroderma" @default.
• W1979528064 cites W1553444759 @default.
• W1979528064 cites W1581433288 @default.
• W1979528064 cites W1936190307 @default.
• W1979528064 cites W1973564464 @default.
• W1979528064 cites W1974079481 @default.
• W1979528064 cites W1991636285 @default.
• W1979528064 cites W1998518931 @default.
• W1979528064 cites W2009396278 @default.
• W1979528064 cites W2012034969 @default.
• W1979528064 cites W2033887719 @default.
• W1979528064 cites W2045580622 @default.
• W1979528064 cites W2048355846 @default.
• W1979528064 cites W2049777820 @default.
• W1979528064 cites W2052649367 @default.
• W1979528064 cites W2058278041 @default.
• W1979528064 cites W2074923230 @default.
• W1979528064 cites W2085747258 @default.
• W1979528064 cites W2092344861 @default.
• W1979528064 cites W2094579915 @default.
• W1979528064 cites W2136312968 @default.
• W1979528064 cites W2161021883 @default.
• W1979528064 cites W2163785527 @default.
• W1979528064 cites W2164615751 @default.
• W1979528064 cites W4235550082 @default.
• W1979528064 cites W4297022993 @default.
• W1979528064 doi "https://doi.org/10.1073/pnas.062010399" @default.
• W1979528064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/122622" @default.
• W1979528064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11904440" @default.
• W1979528064 hasPublicationYear "2002" @default.
• W1979528064 type Work @default.
• W1979528064 sameAs 1979528064 @default.
• W1979528064 citedByCount "229" @default.
• W1979528064 countsByYear W19795280642012 @default.
• W1979528064 countsByYear W19795280642013 @default.
• W1979528064 countsByYear W19795280642014 @default.
• W1979528064 countsByYear W19795280642015 @default.
• W1979528064 countsByYear W19795280642016 @default.
• W1979528064 countsByYear W19795280642017 @default.
• W1979528064 countsByYear W19795280642018 @default.
• W1979528064 countsByYear W19795280642020 @default.
• W1979528064 countsByYear W19795280642021 @default.
• W1979528064 countsByYear W19795280642022 @default.
• W1979528064 crossrefType "journal-article" @default.
• W1979528064 hasAuthorship W1979528064A5006169846 @default.
• W1979528064 hasAuthorship W1979528064A5010548480 @default.
• W1979528064 hasAuthorship W1979528064A5018682870 @default.
• W1979528064 hasAuthorship W1979528064A5033019353 @default.
• W1979528064 hasAuthorship W1979528064A5044432790 @default.
• W1979528064 hasAuthorship W1979528064A5046914597 @default.
• W1979528064 hasAuthorship W1979528064A5060576956 @default.
• W1979528064 hasAuthorship W1979528064A5067962806 @default.
• W1979528064 hasAuthorship W1979528064A5068528030 @default.
• W1979528064 hasAuthorship W1979528064A5085142676 @default.
• W1979528064 hasBestOaLocation W19795280642 @default.
• W1979528064 hasConcept C111001777 @default.
• W1979528064 hasConcept C118131993 @default.
• W1979528064 hasConcept C125555471 @default.
• W1979528064 hasConcept C126322002 @default.
• W1979528064 hasConcept C134018914 @default.
• W1979528064 hasConcept C170493617 @default.
• W1979528064 hasConcept C180032290 @default.
• W1979528064 hasConcept C203014093 @default.
• W1979528064 hasConcept C2775960820 @default.
• W1979528064 hasConcept C2778229498 @default.
• W1979528064 hasConcept C2779967694 @default.
• W1979528064 hasConcept C2780559512 @default.
• W1979528064 hasConcept C2781080636 @default.
• W1979528064 hasConcept C502942594 @default.
• W1979528064 hasConcept C54355233 @default.
• W1979528064 hasConcept C62478195 @default.
• W1979528064 hasConcept C71924100 @default.
• W1979528064 hasConcept C73568257 @default.
• W1979528064 hasConcept C86803240 @default.
• W1979528064 hasConcept C95444343 @default.
• W1979528064 hasConceptScore W1979528064C111001777 @default.
• W1979528064 hasConceptScore W1979528064C118131993 @default.
• W1979528064 hasConceptScore W1979528064C125555471 @default.
• W1979528064 hasConceptScore W1979528064C126322002 @default.
• W1979528064 hasConceptScore W1979528064C134018914 @default.
• W1979528064 hasConceptScore W1979528064C170493617 @default.
• W1979528064 hasConceptScore W1979528064C180032290 @default.
• W1979528064 hasConceptScore W1979528064C203014093 @default.
• W1979528064 hasConceptScore W1979528064C2775960820 @default.

• next