FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982156664> ?p ?o ?g. }

• W1982156664 endingPage "1289" @default.
• W1982156664 startingPage "1284" @default.
• W1982156664 abstract "Nikkomycins X and Z (NZ), competitive inhibitors of fungal chitin synthetase, were combined with azoles in a series of in vitro checkerboard assays to test for synergism against Candida spp. All combinations of nikkomycins and azoles tested resulted in marked synergistic activity against an isolate of Candida albicans, with fractional inhibitory concentration indices ranging from 0.016 to 0.28. No synergistic effect was demonstrable with isolates of C. tropicalis, C. parapsilosis, or C. krusei, though results for the latter two were suggestive of an additive effect. In survival models of mice infected intravenously with C. albicans, NZ administered singly in doses ranging from 5 to 50 mg/kg of body weight twice a day was able to delay the onset of mortality but showed no dose-response effect. The combination of NZ and the azole R 3783 administered orally in a ratio of 8:1 to 40:1 or greater (wt/wt) enhanced survival better than did the drugs given individually, but this effect was less evident for combinations involving fluconazole. In short-term organ load assays with outbred mice infected intravenously with C. albicans, high ratios of NZ to R 3783 reduced the CFU per gram in kidneys more significantly than did the drugs individually. Statistically significant reductions were not seen for short-term fungal burden assays using combinations of NZ and fluconazole in outbred mice or in inbred mice more susceptible to candidiasis. In a model of rat vaginal candidiasis, the combination of NZ and R 3783 administered either orally or vaginally was more effective than the drugs used singly. Thus, under certain conditions, combination therapy with nikkomycin and select azoles may offer promise for an increased therapeutic effect in candidiasis." @default.
• W1982156664 created "2016-06-24" @default.
• W1982156664 creator A5001934703 @default.
• W1982156664 creator A5040542542 @default.
• W1982156664 date "1992-06-01" @default.
• W1982156664 modified "2023-10-01" @default.
• W1982156664 title "Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo" @default.
• W1982156664 cites W1594013448 @default.
• W1982156664 cites W2004614326 @default.
• W1982156664 cites W2022314625 @default.
• W1982156664 cites W2025172543 @default.
• W1982156664 cites W2028571506 @default.
• W1982156664 cites W2030491764 @default.
• W1982156664 cites W2032386216 @default.
• W1982156664 cites W2040691700 @default.
• W1982156664 cites W2041711975 @default.
• W1982156664 cites W2042147469 @default.
• W1982156664 cites W2048389726 @default.
• W1982156664 cites W2059477755 @default.
• W1982156664 cites W2060724686 @default.
• W1982156664 cites W2064257827 @default.
• W1982156664 cites W2082544860 @default.
• W1982156664 cites W2102216508 @default.
• W1982156664 cites W2135118098 @default.
• W1982156664 cites W2144309623 @default.
• W1982156664 cites W2149387438 @default.
• W1982156664 cites W2166675124 @default.
• W1982156664 cites W2309429913 @default.
• W1982156664 cites W2316966679 @default.
• W1982156664 cites W2333532785 @default.
• W1982156664 doi "https://doi.org/10.1128/aac.36.6.1284" @default.
• W1982156664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190333" @default.
• W1982156664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1416829" @default.
• W1982156664 hasPublicationYear "1992" @default.
• W1982156664 type Work @default.
• W1982156664 sameAs 1982156664 @default.
• W1982156664 citedByCount "46" @default.
• W1982156664 countsByYear W19821566642012 @default.
• W1982156664 countsByYear W19821566642013 @default.
• W1982156664 countsByYear W19821566642014 @default.
• W1982156664 countsByYear W19821566642015 @default.
• W1982156664 countsByYear W19821566642017 @default.
• W1982156664 countsByYear W19821566642022 @default.
• W1982156664 countsByYear W19821566642023 @default.
• W1982156664 crossrefType "journal-article" @default.
• W1982156664 hasAuthorship W1982156664A5001934703 @default.
• W1982156664 hasAuthorship W1982156664A5040542542 @default.
• W1982156664 hasBestOaLocation W19821566641 @default.
• W1982156664 hasConcept C145081991 @default.
• W1982156664 hasConcept C150903083 @default.
• W1982156664 hasConcept C176947019 @default.
• W1982156664 hasConcept C202751555 @default.
• W1982156664 hasConcept C207001950 @default.
• W1982156664 hasConcept C2775835631 @default.
• W1982156664 hasConcept C2779443200 @default.
• W1982156664 hasConcept C2779548794 @default.
• W1982156664 hasConcept C2780315139 @default.
• W1982156664 hasConcept C2780651595 @default.
• W1982156664 hasConcept C2780917455 @default.
• W1982156664 hasConcept C2781425774 @default.
• W1982156664 hasConcept C501593827 @default.
• W1982156664 hasConcept C55493867 @default.
• W1982156664 hasConcept C86803240 @default.
• W1982156664 hasConcept C89423630 @default.
• W1982156664 hasConcept C98274493 @default.
• W1982156664 hasConceptScore W1982156664C145081991 @default.
• W1982156664 hasConceptScore W1982156664C150903083 @default.
• W1982156664 hasConceptScore W1982156664C176947019 @default.
• W1982156664 hasConceptScore W1982156664C202751555 @default.
• W1982156664 hasConceptScore W1982156664C207001950 @default.
• W1982156664 hasConceptScore W1982156664C2775835631 @default.
• W1982156664 hasConceptScore W1982156664C2779443200 @default.
• W1982156664 hasConceptScore W1982156664C2779548794 @default.
• W1982156664 hasConceptScore W1982156664C2780315139 @default.
• W1982156664 hasConceptScore W1982156664C2780651595 @default.
• W1982156664 hasConceptScore W1982156664C2780917455 @default.
• W1982156664 hasConceptScore W1982156664C2781425774 @default.
• W1982156664 hasConceptScore W1982156664C501593827 @default.
• W1982156664 hasConceptScore W1982156664C55493867 @default.
• W1982156664 hasConceptScore W1982156664C86803240 @default.
• W1982156664 hasConceptScore W1982156664C89423630 @default.
• W1982156664 hasConceptScore W1982156664C98274493 @default.
• W1982156664 hasIssue "6" @default.
• W1982156664 hasLocation W19821566641 @default.
• W1982156664 hasLocation W19821566642 @default.
• W1982156664 hasLocation W19821566643 @default.
• W1982156664 hasOpenAccess W1982156664 @default.
• W1982156664 hasPrimaryLocation W19821566641 @default.
• W1982156664 hasRelatedWork W1562655438 @default.
• W1982156664 hasRelatedWork W1982156664 @default.
• W1982156664 hasRelatedWork W1984053219 @default.
• W1982156664 hasRelatedWork W2015014072 @default.
• W1982156664 hasRelatedWork W2015427937 @default.
• W1982156664 hasRelatedWork W2114699747 @default.
• W1982156664 hasRelatedWork W2261249905 @default.
• W1982156664 hasRelatedWork W2520000334 @default.
• W1982156664 hasRelatedWork W3030658457 @default.
• W1982156664 hasRelatedWork W4294219026 @default.

• next