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- W1982481623 abstract "It has been suggested that pituitary hormone might be associated with bone metabolism. To investigate the role of thyroid-stimulating hormone (TSH) in bone metabolism, we designed the present study as follows. After weaning, TSH receptor (TSHR) null mice (Tshr−/−) were randomly divided into a thyroxine treatment group (n=10) or non-treatment group (n=10); the treatment group received a dose of desiccated thyroid extract at 100 ppm daily for 5 weeks. Age-matched wild-type (Tshr+/+, n=10) and heterozygote mice (Tshr+/−, n=10) served as controls. After 5 weeks, the animals were sacrificed, and the femurs were collected for histomorphometrical and biomechanical analyses. In addition, the effect of TSH on osteoclastogenesis was examined in the RAW264.7 osteoclast cell line. We found that compared with Tshr+/+ mice, Tshr−/− and Tshr+/− mice had lower bone strength. The histomorphometric results showed that trabecular bone volume, osteoid surface, osteoid thickness and osteoblast surface were significantly decreased, whereas the osteoclast surface was significantly increased in both Tshr−/− and Tshr+/− mice compared with Tshr+/+ mice. Bone resorption and formation in Tshr−/− mice were further enhanced by thyroxine replacement. bTSH inhibited osteoclast differentiation in vitro, as demonstrated by reduced development of TRAP-positive cells and down-regulation of differentiation markers, including tartrate-resistant acid phosphatase, matrix metallo-proteinase-9 and cathepsin K in RAW264.7 cells. Our results confirm that TSH increased bone volume and improved bone microarchitecture and strength at least partly by inhibiting osteoclastogenesis." @default.
- W1982481623 created "2016-06-24" @default.
- W1982481623 creator A5025309775 @default.
- W1982481623 creator A5015832619 @default.
- W1982481623 date "1976-01-01" @default.
- W1982481623 modified "2023-09-25" @default.
- W1982481623 title "Comparative clinical pharmacology of thyroid hormones" @default.
- W1982481623 cites W103213098 @default.
- W1982481623 cites W1504168102 @default.
- W1982481623 cites W1556277855 @default.
- W1982481623 cites W1594322467 @default.
- W1982481623 cites W1967026567 @default.
- W1982481623 cites W1970658009 @default.
- W1982481623 cites W1970871311 @default.
- W1982481623 cites W1972020690 @default.
- W1982481623 cites W1973964502 @default.
- W1982481623 cites W1974794371 @default.
- W1982481623 cites W1975100497 @default.
- W1982481623 cites W1977492795 @default.
- W1982481623 cites W1981360211 @default.
- W1982481623 cites W1984453496 @default.
- W1982481623 cites W1984692467 @default.
- W1982481623 cites W1987037995 @default.
- W1982481623 cites W1990211089 @default.
- W1982481623 cites W1990550978 @default.
- W1982481623 cites W1994027777 @default.
- W1982481623 cites W2002110181 @default.
- W1982481623 cites W2002920901 @default.
- W1982481623 cites W2006349062 @default.
- W1982481623 cites W2006457802 @default.
- W1982481623 cites W2006868095 @default.
- W1982481623 cites W2011154416 @default.
- W1982481623 cites W2011336959 @default.
- W1982481623 cites W2011482612 @default.
- W1982481623 cites W2013335967 @default.
- W1982481623 cites W2017623791 @default.
- W1982481623 cites W2017846373 @default.
- W1982481623 cites W2019176996 @default.
- W1982481623 cites W2019468173 @default.
- W1982481623 cites W2021515095 @default.
- W1982481623 cites W2021532730 @default.
- W1982481623 cites W2022127841 @default.
- W1982481623 cites W2022350011 @default.
- W1982481623 cites W2024029729 @default.
- W1982481623 cites W2024064697 @default.
- W1982481623 cites W2024178467 @default.
- W1982481623 cites W2024600112 @default.
- W1982481623 cites W2025136560 @default.
- W1982481623 cites W2027387686 @default.
- W1982481623 cites W2028691157 @default.
- W1982481623 cites W2031131540 @default.
- W1982481623 cites W2031591093 @default.
- W1982481623 cites W2032775068 @default.
- W1982481623 cites W2033265097 @default.
- W1982481623 cites W2034859364 @default.
- W1982481623 cites W2034899611 @default.
- W1982481623 cites W2039437090 @default.
- W1982481623 cites W2041160265 @default.
- W1982481623 cites W2042457438 @default.
- W1982481623 cites W2045004911 @default.
- W1982481623 cites W2047584372 @default.
- W1982481623 cites W2048461474 @default.
- W1982481623 cites W2051561418 @default.
- W1982481623 cites W2053462528 @default.
- W1982481623 cites W2056630806 @default.
- W1982481623 cites W2056664245 @default.
- W1982481623 cites W2058225934 @default.
- W1982481623 cites W2062536266 @default.
- W1982481623 cites W2063068525 @default.
- W1982481623 cites W2064636502 @default.
- W1982481623 cites W2067276001 @default.
- W1982481623 cites W2069254422 @default.
- W1982481623 cites W2071896069 @default.
- W1982481623 cites W2073488093 @default.
- W1982481623 cites W2073707684 @default.
- W1982481623 cites W2073836296 @default.
- W1982481623 cites W2074196787 @default.
- W1982481623 cites W2074520263 @default.
- W1982481623 cites W2075684609 @default.
- W1982481623 cites W2085611737 @default.
- W1982481623 cites W2085734270 @default.
- W1982481623 cites W2088454026 @default.
- W1982481623 cites W2088575802 @default.
- W1982481623 cites W2092343378 @default.
- W1982481623 cites W2092912006 @default.
- W1982481623 cites W2093006117 @default.
- W1982481623 cites W2093111163 @default.
- W1982481623 cites W2094196590 @default.
- W1982481623 cites W2095238836 @default.
- W1982481623 cites W2106088399 @default.
- W1982481623 cites W2112902776 @default.
- W1982481623 cites W2119074058 @default.
- W1982481623 cites W2135957727 @default.
- W1982481623 cites W2145894306 @default.
- W1982481623 cites W2158270564 @default.
- W1982481623 cites W2160583708 @default.
- W1982481623 cites W2193104832 @default.
- W1982481623 cites W2317475302 @default.