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- W1983853935 abstract "The association of two proteins is bounded by the rate at which they, via diffusion, find each other while in appropriate relative orientations. Orientational constraints restrict this rate to ∼105–106 M−1 s−1. Proteins with higher association rates generally have complementary electrostatic surfaces; proteins with lower association rates generally are slowed down by conformational changes upon complex formation. Previous studies (Zhou, Biophys J 1997;73:2441–2445) have shown that electrostatic enhancement of the diffusion-limited association rate can be accurately modeled by = where kD and kD0 are the rates in the presence and absence of electrostatic interactions, respectively, 〈Uel〉☆ is the average electrostatic interaction energy in a “transient-complex” ensemble, and kBT is the thermal energy. The transient-complex ensemble separates the bound state from the unbound state. Predictions of the transient-complex theory on four protein complexes were found to agree well with the experiment when the electrostatic interaction energy was calculated with the linearized Poisson–Boltzmann (PB) equation (Alsallaq and Zhou, Structure 2007;15:215–224). Here we show that the agreement is further improved when the nonlinear PB equation is used. These predictions are obtained with the dielectric boundary defined as the protein van der Waals surface. When the dielectric boundary is instead specified as the molecular surface, electrostatic interactions in the transient complex become repulsive and are thus predicted to retard association. Together these results demonstrate that the transient-complex theory is predictive of electrostatic rate enhancement and can help parameterize PB calculations. Proteins 2008. © 2007 Wiley-Liss, Inc." @default.
- W1983853935 created "2016-06-24" @default.
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- W1983853935 date "2008-01-01" @default.
- W1983853935 modified "2023-10-01" @default.
- W1983853935 title "Electrostatic rate enhancement and transient complex of protein–protein association" @default.
- W1983853935 cites W1595181072 @default.
- W1983853935 cites W1965825504 @default.
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- W1983853935 cites W1969876717 @default.
- W1983853935 cites W1972335910 @default.
- W1983853935 cites W1976970073 @default.
- W1983853935 cites W1986089752 @default.
- W1983853935 cites W1988298107 @default.
- W1983853935 cites W1989925383 @default.
- W1983853935 cites W2007336932 @default.
- W1983853935 cites W2008743460 @default.
- W1983853935 cites W2010143056 @default.
- W1983853935 cites W2010537388 @default.
- W1983853935 cites W2012667720 @default.
- W1983853935 cites W2013550462 @default.
- W1983853935 cites W2015039690 @default.
- W1983853935 cites W2015305097 @default.
- W1983853935 cites W2023387870 @default.
- W1983853935 cites W2023925264 @default.
- W1983853935 cites W2029197401 @default.
- W1983853935 cites W2029582401 @default.
- W1983853935 cites W2030020537 @default.
- W1983853935 cites W2030612164 @default.
- W1983853935 cites W2030828742 @default.
- W1983853935 cites W2030841140 @default.
- W1983853935 cites W2032937791 @default.
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- W1983853935 cites W2037079678 @default.
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- W1983853935 cites W2038996488 @default.
- W1983853935 cites W2039924429 @default.
- W1983853935 cites W2043981631 @default.
- W1983853935 cites W2050699163 @default.
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- W1983853935 cites W2053246876 @default.
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- W1983853935 cites W2057980421 @default.
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- W1983853935 doi "https://doi.org/10.1002/prot.21679" @default.
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