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• W1984887029 abstract "Mu opioid receptor antagonists have clinical utility and are important research tools. To develop non-peptide and highly selective mu opioid receptor antagonist, a series of 14-O-heterocyclic-substituted naltrexone derivatives were designed, synthesized, and evaluated. These compounds showed subnanomolar-to-nanomolar binding affinity for the mu opioid receptor. Among them, compound 1 exhibited the highest selectivity for the mu opioid receptor over the delta and kappa receptors. These results implicated an alternative ‘address’ domain in the extracellular loops of the mu opioid receptor." @default.
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• W1984887029 date "2009-03-01" @default.
• W1984887029 modified "2023-10-02" @default.
• W1984887029 title "14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: Design, synthesis, and biological studies" @default.
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• W1984887029 doi "https://doi.org/10.1016/j.bmcl.2008.12.093" @default.
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