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• W1985753260 abstract "<i>Aim:</i> To establish the prevalence of elevated thyroid-stimulating hormone (TSH) levels in obese children and adolescents, and identify the relationship between changes in TSH levels and other metabolic and hormonal variables before and after weight reduction. <i>Methods:</i> 207 obese participants aged 5–18 years were evaluated for anthropometric, biochemical, metabolic and hormonal variables before and after a weight reduction. <i>Results:</i> At baseline, 46 participants (22.2%) had hyperthyrotropinemia (≥4.0 mIU/l). Free T₄ levels were normal in all cases. Triglyceride levels were significantly higher in participants with hyperthyrotropinemia than in those with normal thyroid function (p = 0.011). Baseline TSH was significantly correlated with triglyceride levels (r = 0.261, p < 0.001), but not with age, anthropometric, or laboratory variables. Of the 142 participants who completed the intervention, 27 (19 %) had hyperthyrotropinemia. There was no significant relationship between changes in TSH level and changes in body mass index-standard deviation score. A significant correlation was found between the final TSH level and triglyceride level (r = 0.167, p = 0.045), and between the decrease in TSH level and the decrease in waist circumference (r = 0.291, p = 0.013). <i>Conclusions:</i> In obese children, hyperthyrotropinemia with normal free T₄ levels appears to be frequent. The correlation of hyperthyrotropinemia with waist circumference and higher triglyceride levels raises the question of the necessity to treat the elevated TSH levels." @default.
• W1985753260 created "2016-06-24" @default.
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• W1985753260 date "2009-01-01" @default.
• W1985753260 modified "2023-10-16" @default.
• W1985753260 title "Prevalence of Thyroid Dysfunction in Obese Children and Adolescents before and after Weight Reduction and Its Relation to Other Metabolic Parameters" @default.
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• W1985753260 doi "https://doi.org/10.1159/000197872" @default.
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