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• W1985989203 abstract "1. Intracellular potentials and measurements of contractions were recorded in adjacent veins and arteries in the colonic mesentery of the guinea-pig in vitro during stimulation of post-ganglionic nerve trunks. 2. Repetitive stimulation (0.5-5 Hz) of lumbar colonic nerve trunks produced frequency-dependent slow depolarizations in all venous and in 92% of arterial smooth muscle cells. Excitatory junction potentials were observed for each nerve shock in arteries, but not in veins. 3. Low-frequency stimulations produced slow depolarizations of greater amplitude and longer duration in veins than in arteries. The frequencies at which half-maximal depolarizations and contractions occurred were always lower for veins than for arteries. 4. The alpha 1-adrenergic antagonist prazosin (5 X 10(-7) M) reduced the mean arterial slow depolarizations by 82% and reduced mean venous slow depolarizations by 58% for 5 Hz stimulations. Arterial contractions were completely inhibited by prazosin but venous contractions were incompletely reduced in a frequency-dependent manner. 5. These findings suggest that functional differences in activation between mesenteric veins and arteries during sympathetic stimulation are a result of differences in neuromuscular transmission." @default.
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• W1985989203 date "1987-03-01" @default.
• W1985989203 modified "2023-10-15" @default.
• W1985989203 title "Comparison of the frequency dependence of venous and arterial responses to sympathetic nerve stimulation in guinea-pigs." @default.
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• W1985989203 doi "https://doi.org/10.1113/jphysiol.1987.sp016448" @default.
• W1985989203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1192256" @default.
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