FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990367048> ?p ?o ?g. }

• W1990367048 endingPage "641" @default.
• W1990367048 startingPage "638" @default.
• W1990367048 abstract "We attempted to determine the role of endothelin in a previously characterized animal model of preeclampsia by studying the effect of a specific endothelin antagonist, BQ123, on blood pressure.A preeclampsia-like condition was induced by infusing pregnant rats with the nitric oxide synthase inhibitor N(G)-nitro-L -arginine methyl ester. Osmotic minipumps were inserted subcutaneously into timed pregnant Harlan-Sprague-Dawley rats on day 17 of pregnancy (term, 22 days). The pumps were loaded to continuously deliver either vehicle (control group) or N(G)-nitro-L -arginine methyl ester 50 mg/d, either alone or with BQ123 at 0.5 mg/d. In a similar but separate experiment, the dose of BQ123 was increased to 1 mg/d. Blood pressure was measured with the tail-cuff method before pump insertion and then daily until postpartum day 2.Except for a decrease on the day after pump insertion, BQ123 0.5 mg/d had no significant effect on the hypertension induced by N(G)-nitro-L -arginine methyl ester. At the higher dose, however, BQ123 significantly attenuated the increase in blood pressure induced by N(G)-nitro-L -arginine methyl ester during most of the study period.The effect of nitric oxide inhibition can be successfully attenuated by the use of an endothelin antagonist, thereby supporting the role of endothelin in the hypertension described with the preeclampsialike condition seen in pregnant rats." @default.
• W1990367048 created "2016-06-24" @default.
• W1990367048 creator A5046471717 @default.
• W1990367048 creator A5060166195 @default.
• W1990367048 creator A5076296942 @default.
• W1990367048 creator A5087722386 @default.
• W1990367048 creator A5088324465 @default.
• W1990367048 date "1999-09-01" @default.
• W1990367048 modified "2023-10-18" @default.
• W1990367048 title "The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia" @default.
• W1990367048 cites W1918788146 @default.
• W1990367048 cites W1974891862 @default.
• W1990367048 cites W1976740853 @default.
• W1990367048 cites W1988566514 @default.
• W1990367048 cites W1991224723 @default.
• W1990367048 cites W2001915853 @default.
• W1990367048 cites W2007266356 @default.
• W1990367048 cites W2010842674 @default.
• W1990367048 cites W2013409143 @default.
• W1990367048 cites W2017543118 @default.
• W1990367048 cites W2032469975 @default.
• W1990367048 cites W2032772517 @default.
• W1990367048 cites W2036342637 @default.
• W1990367048 cites W2045385733 @default.
• W1990367048 cites W2055940117 @default.
• W1990367048 cites W2058752988 @default.
• W1990367048 cites W2068913331 @default.
• W1990367048 cites W2072061985 @default.
• W1990367048 cites W2072739223 @default.
• W1990367048 cites W2075653035 @default.
• W1990367048 cites W2080399103 @default.
• W1990367048 cites W2089500756 @default.
• W1990367048 cites W2106303873 @default.
• W1990367048 cites W2322088294 @default.
• W1990367048 cites W2466436244 @default.
• W1990367048 doi "https://doi.org/10.1016/s0002-9378(99)70506-5" @default.
• W1990367048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10486477" @default.
• W1990367048 hasPublicationYear "1999" @default.
• W1990367048 type Work @default.
• W1990367048 sameAs 1990367048 @default.
• W1990367048 citedByCount "13" @default.
• W1990367048 countsByYear W19903670482012 @default.
• W1990367048 countsByYear W19903670482013 @default.
• W1990367048 countsByYear W19903670482015 @default.
• W1990367048 countsByYear W19903670482017 @default.
• W1990367048 crossrefType "journal-article" @default.
• W1990367048 hasAuthorship W1990367048A5046471717 @default.
• W1990367048 hasAuthorship W1990367048A5060166195 @default.
• W1990367048 hasAuthorship W1990367048A5076296942 @default.
• W1990367048 hasAuthorship W1990367048A5087722386 @default.
• W1990367048 hasAuthorship W1990367048A5088324465 @default.
• W1990367048 hasConcept C126322002 @default.
• W1990367048 hasConcept C134018914 @default.
• W1990367048 hasConcept C144980905 @default.
• W1990367048 hasConcept C149601957 @default.
• W1990367048 hasConcept C170493617 @default.
• W1990367048 hasConcept C2776885963 @default.
• W1990367048 hasConcept C2777218350 @default.
• W1990367048 hasConcept C2777622882 @default.
• W1990367048 hasConcept C2779234561 @default.
• W1990367048 hasConcept C519581460 @default.
• W1990367048 hasConcept C54355233 @default.
• W1990367048 hasConcept C71924100 @default.
• W1990367048 hasConcept C84393581 @default.
• W1990367048 hasConcept C86803240 @default.
• W1990367048 hasConceptScore W1990367048C126322002 @default.
• W1990367048 hasConceptScore W1990367048C134018914 @default.
• W1990367048 hasConceptScore W1990367048C144980905 @default.
• W1990367048 hasConceptScore W1990367048C149601957 @default.
• W1990367048 hasConceptScore W1990367048C170493617 @default.
• W1990367048 hasConceptScore W1990367048C2776885963 @default.
• W1990367048 hasConceptScore W1990367048C2777218350 @default.
• W1990367048 hasConceptScore W1990367048C2777622882 @default.
• W1990367048 hasConceptScore W1990367048C2779234561 @default.
• W1990367048 hasConceptScore W1990367048C519581460 @default.
• W1990367048 hasConceptScore W1990367048C54355233 @default.
• W1990367048 hasConceptScore W1990367048C71924100 @default.
• W1990367048 hasConceptScore W1990367048C84393581 @default.
• W1990367048 hasConceptScore W1990367048C86803240 @default.
• W1990367048 hasIssue "3" @default.
• W1990367048 hasLocation W19903670481 @default.
• W1990367048 hasLocation W19903670482 @default.
• W1990367048 hasOpenAccess W1990367048 @default.
• W1990367048 hasPrimaryLocation W19903670481 @default.
• W1990367048 hasRelatedWork W1983371938 @default.
• W1990367048 hasRelatedWork W1997169304 @default.
• W1990367048 hasRelatedWork W2006736256 @default.
• W1990367048 hasRelatedWork W2032437128 @default.
• W1990367048 hasRelatedWork W2062955868 @default.
• W1990367048 hasRelatedWork W2095084418 @default.
• W1990367048 hasRelatedWork W2141307244 @default.
• W1990367048 hasRelatedWork W2160355439 @default.
• W1990367048 hasRelatedWork W2393521223 @default.
• W1990367048 hasRelatedWork W2432673099 @default.
• W1990367048 hasVolume "181" @default.
• W1990367048 isParatext "false" @default.
• W1990367048 isRetracted "false" @default.
• W1990367048 magId "1990367048" @default.

• next