Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991232661> ?p ?o ?g. }
- W1991232661 endingPage "771" @default.
- W1991232661 startingPage "762" @default.
- W1991232661 abstract "Background: Many previous clinical studies of food-induced asthma suffer from inadequate baseline or control data. A statistically valid, randomized, double-blind, placebo-controlled, monosodium glutamate (MSG)–challenge protocol was developed for identifying early and late asthmatic reactions in an individual. Objective: We sought to determine whether MSG would induce bronchoconstriction in a group of adults with asthma who perceived that they were MSG sensitive. Methods: Twelve subjects (seven women, mean age 35.3 years) with clinically documented asthma and a perception of MSG-induced asthma were recruited. FEV 1 and peak expiratory flow data were obtained for 3 whole control days, as well as time-matched data for 3 separate challenge days (1 gm MSG, 5 gm MSG, and 5 gm lactose [placebo]). Opaque capsule challenges were given as a single dose in the morning after an overnight fast. Subjects complied with an elimination diet throughout the study. Nonspecific bronchial hyperresponsiveness was measured at baseline, after the control days, and at the conclusion of the challenges. Venous blood samples were taken at baseline and on each challenge day to determine soluble inflammatory marker (eosinophil cationic protein and tryptase) activity. Results: No immediate or definite late asthmatic reactions occurred. One subject's FEV 1 declined more than 15% on MSG challenge, but 95% confidence limits for the control-day spirometry showed that this decline was within her daily variation, hence the challenge was deemed to be negative. No significant changes in bronchial hyperresponsiveness or soluble inflammatory markers were found. Conclusions: MSG-induced asthma was not demonstrated in this study. This study highlighted the importance of adequate baseline and control data and indicated that such a rigorous protocol for individual assessment is feasible. (J Allergy Clin Immunol 1998;101:762-71.)" @default.
- W1991232661 created "2016-06-24" @default.
- W1991232661 creator A5004903945 @default.
- W1991232661 creator A5016863615 @default.
- W1991232661 creator A5024671852 @default.
- W1991232661 creator A5048753406 @default.
- W1991232661 creator A5061882933 @default.
- W1991232661 date "1998-06-01" @default.
- W1991232661 modified "2023-09-23" @default.
- W1991232661 title "The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate–intolerant☆☆☆★★★" @default.
- W1991232661 cites W1966348400 @default.
- W1991232661 cites W1979031529 @default.
- W1991232661 cites W1982582815 @default.
- W1991232661 cites W1983119973 @default.
- W1991232661 cites W1989245413 @default.
- W1991232661 cites W1996442679 @default.
- W1991232661 cites W2010402406 @default.
- W1991232661 cites W2012008763 @default.
- W1991232661 cites W2012967283 @default.
- W1991232661 cites W2015795623 @default.
- W1991232661 cites W2038773259 @default.
- W1991232661 cites W2045827836 @default.
- W1991232661 cites W2057066149 @default.
- W1991232661 cites W205952945 @default.
- W1991232661 cites W2075671584 @default.
- W1991232661 cites W2081247915 @default.
- W1991232661 cites W2098367882 @default.
- W1991232661 cites W2170541252 @default.
- W1991232661 cites W2299925911 @default.
- W1991232661 cites W2412583831 @default.
- W1991232661 cites W2464028491 @default.
- W1991232661 cites W2472680510 @default.
- W1991232661 cites W2594275191 @default.
- W1991232661 cites W2604596332 @default.
- W1991232661 cites W2985646897 @default.
- W1991232661 doi "https://doi.org/10.1016/s0091-6749(98)70305-7" @default.
- W1991232661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9648703" @default.
- W1991232661 hasPublicationYear "1998" @default.
- W1991232661 type Work @default.
- W1991232661 sameAs 1991232661 @default.
- W1991232661 citedByCount "44" @default.
- W1991232661 countsByYear W19912326612012 @default.
- W1991232661 countsByYear W19912326612013 @default.
- W1991232661 countsByYear W19912326612014 @default.
- W1991232661 countsByYear W19912326612015 @default.
- W1991232661 countsByYear W19912326612017 @default.
- W1991232661 countsByYear W19912326612019 @default.
- W1991232661 countsByYear W19912326612022 @default.
- W1991232661 crossrefType "journal-article" @default.
- W1991232661 hasAuthorship W1991232661A5004903945 @default.
- W1991232661 hasAuthorship W1991232661A5016863615 @default.
- W1991232661 hasAuthorship W1991232661A5024671852 @default.
- W1991232661 hasAuthorship W1991232661A5048753406 @default.
- W1991232661 hasAuthorship W1991232661A5061882933 @default.
- W1991232661 hasBestOaLocation W19912326611 @default.
- W1991232661 hasConcept C126322002 @default.
- W1991232661 hasConcept C142724271 @default.
- W1991232661 hasConcept C19720800 @default.
- W1991232661 hasConcept C203014093 @default.
- W1991232661 hasConcept C204787440 @default.
- W1991232661 hasConcept C207480886 @default.
- W1991232661 hasConcept C27081682 @default.
- W1991232661 hasConcept C2776042228 @default.
- W1991232661 hasConcept C2776178081 @default.
- W1991232661 hasConcept C2776238763 @default.
- W1991232661 hasConcept C2776989845 @default.
- W1991232661 hasConcept C2777037409 @default.
- W1991232661 hasConcept C2777714996 @default.
- W1991232661 hasConcept C2780333948 @default.
- W1991232661 hasConcept C2780769369 @default.
- W1991232661 hasConcept C71924100 @default.
- W1991232661 hasConcept C88675164 @default.
- W1991232661 hasConcept C90924648 @default.
- W1991232661 hasConceptScore W1991232661C126322002 @default.
- W1991232661 hasConceptScore W1991232661C142724271 @default.
- W1991232661 hasConceptScore W1991232661C19720800 @default.
- W1991232661 hasConceptScore W1991232661C203014093 @default.
- W1991232661 hasConceptScore W1991232661C204787440 @default.
- W1991232661 hasConceptScore W1991232661C207480886 @default.
- W1991232661 hasConceptScore W1991232661C27081682 @default.
- W1991232661 hasConceptScore W1991232661C2776042228 @default.
- W1991232661 hasConceptScore W1991232661C2776178081 @default.
- W1991232661 hasConceptScore W1991232661C2776238763 @default.
- W1991232661 hasConceptScore W1991232661C2776989845 @default.
- W1991232661 hasConceptScore W1991232661C2777037409 @default.
- W1991232661 hasConceptScore W1991232661C2777714996 @default.
- W1991232661 hasConceptScore W1991232661C2780333948 @default.
- W1991232661 hasConceptScore W1991232661C2780769369 @default.
- W1991232661 hasConceptScore W1991232661C71924100 @default.
- W1991232661 hasConceptScore W1991232661C88675164 @default.
- W1991232661 hasConceptScore W1991232661C90924648 @default.
- W1991232661 hasIssue "6" @default.
- W1991232661 hasLocation W19912326611 @default.
- W1991232661 hasLocation W19912326612 @default.
- W1991232661 hasOpenAccess W1991232661 @default.
- W1991232661 hasPrimaryLocation W19912326611 @default.
- W1991232661 hasRelatedWork W1967351750 @default.
- W1991232661 hasRelatedWork W2013149735 @default.