FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997390819> ?p ?o ?g. }

• W1997390819 endingPage "519" @default.
• W1997390819 startingPage "510" @default.
• W1997390819 abstract "Hyaluronan (HA) is an essential component of synovial interstitial matrix and synovial fluid, but the link between its production and joint use is unclear. HA secretion is enhanced by joint distension in vivo, but direct proof that synoviocytes exhibit mechanosensitive HA secretion is lacking. We tested this in vitro. Primary rabbit synoviocyte (PRS) cultures from microdissected synovial intima were subjected to 180 min of maintained 10% static stretch, or to 10 min of 10% static stretch followed by 170 min relaxation, in a Flexcell 2000 apparatus. Stretch stimulated HA secretion into the medium over 3 h by 57%. Notably, a short stretch (10 min) was as effective as sustained stretch. Actinomycin D and cycloheximide abolished stretch-stimulated HA secretion and also reduced basal HA secretion rate. RT-PCR showed that HAS2 was the major hyaluronan synthase expressed, but there was no increase in HAS2 mRNA (or other isoforms) in continuously stretched cells, and only a small increase (20%) at 180 min in cells stretched for the first 10–30 min. However HAS2 transcription increased 10-fold in response to TGF-β1 and IL-1β. Thus HA secretion by intimal synoviocytes is regulated by a mechanosensitive pathway which depends on transcription and de novo protein synthesis, possibly of HAS2, but also of other proteins involved in HA secretion." @default.
• W1997390819 created "2016-06-24" @default.
• W1997390819 creator A5037453300 @default.
• W1997390819 creator A5058551322 @default.
• W1997390819 creator A5077600402 @default.
• W1997390819 date "2005-12-01" @default.
• W1997390819 modified "2023-09-27" @default.
• W1997390819 title "Hyaluronan secretion by synoviocytes is mechanosensitive" @default.
• W1997390819 cites W129505980 @default.
• W1997390819 cites W1488596745 @default.
• W1997390819 cites W1529198223 @default.
• W1997390819 cites W1563244824 @default.
• W1997390819 cites W1599989986 @default.
• W1997390819 cites W1927510738 @default.
• W1997390819 cites W1965435354 @default.
• W1997390819 cites W1977436263 @default.
• W1997390819 cites W1980911592 @default.
• W1997390819 cites W1989608005 @default.
• W1997390819 cites W1992006012 @default.
• W1997390819 cites W1995857138 @default.
• W1997390819 cites W1997247250 @default.
• W1997390819 cites W2004707480 @default.
• W1997390819 cites W2007381835 @default.
• W1997390819 cites W2021802559 @default.
• W1997390819 cites W2023532022 @default.
• W1997390819 cites W2023982143 @default.
• W1997390819 cites W2032382337 @default.
• W1997390819 cites W2038886248 @default.
• W1997390819 cites W2040551725 @default.
• W1997390819 cites W2057267126 @default.
• W1997390819 cites W2068272711 @default.
• W1997390819 cites W2072167574 @default.
• W1997390819 cites W2072934882 @default.
• W1997390819 cites W2079281590 @default.
• W1997390819 cites W2082452847 @default.
• W1997390819 cites W2086520451 @default.
• W1997390819 cites W2103961160 @default.
• W1997390819 cites W2105367923 @default.
• W1997390819 cites W2111944995 @default.
• W1997390819 cites W2117355565 @default.
• W1997390819 cites W2123689762 @default.
• W1997390819 cites W2130285647 @default.
• W1997390819 cites W2158594995 @default.
• W1997390819 cites W2158714788 @default.
• W1997390819 cites W2159228692 @default.
• W1997390819 cites W2167704983 @default.
• W1997390819 cites W2189280733 @default.
• W1997390819 cites W2235383568 @default.
• W1997390819 cites W2346166755 @default.
• W1997390819 cites W2408833976 @default.
• W1997390819 cites W2342285418 @default.
• W1997390819 doi "https://doi.org/10.1016/j.matbio.2005.08.006" @default.
• W1997390819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1413575" @default.
• W1997390819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16226884" @default.
• W1997390819 hasPublicationYear "2005" @default.
• W1997390819 type Work @default.
• W1997390819 sameAs 1997390819 @default.
• W1997390819 citedByCount "61" @default.
• W1997390819 countsByYear W19973908192012 @default.
• W1997390819 countsByYear W19973908192013 @default.
• W1997390819 countsByYear W19973908192014 @default.
• W1997390819 countsByYear W19973908192016 @default.
• W1997390819 countsByYear W19973908192017 @default.
• W1997390819 countsByYear W19973908192018 @default.
• W1997390819 countsByYear W19973908192019 @default.
• W1997390819 countsByYear W19973908192020 @default.
• W1997390819 countsByYear W19973908192021 @default.
• W1997390819 countsByYear W19973908192022 @default.
• W1997390819 countsByYear W19973908192023 @default.
• W1997390819 crossrefType "journal-article" @default.
• W1997390819 hasAuthorship W1997390819A5037453300 @default.
• W1997390819 hasAuthorship W1997390819A5058551322 @default.
• W1997390819 hasAuthorship W1997390819A5077600402 @default.
• W1997390819 hasBestOaLocation W19973908192 @default.
• W1997390819 hasConcept C126322002 @default.
• W1997390819 hasConcept C134018914 @default.
• W1997390819 hasConcept C142724271 @default.
• W1997390819 hasConcept C153911025 @default.
• W1997390819 hasConcept C170493617 @default.
• W1997390819 hasConcept C185592680 @default.
• W1997390819 hasConcept C189165786 @default.
• W1997390819 hasConcept C204787440 @default.
• W1997390819 hasConcept C2776164576 @default.
• W1997390819 hasConcept C2776268809 @default.
• W1997390819 hasConcept C2778128677 @default.
• W1997390819 hasConcept C2781236742 @default.
• W1997390819 hasConcept C3675279 @default.
• W1997390819 hasConcept C4001165 @default.
• W1997390819 hasConcept C49039625 @default.
• W1997390819 hasConcept C50254741 @default.
• W1997390819 hasConcept C55493867 @default.
• W1997390819 hasConcept C71924100 @default.
• W1997390819 hasConcept C86803240 @default.
• W1997390819 hasConcept C95444343 @default.
• W1997390819 hasConceptScore W1997390819C126322002 @default.
• W1997390819 hasConceptScore W1997390819C134018914 @default.
• W1997390819 hasConceptScore W1997390819C142724271 @default.
• W1997390819 hasConceptScore W1997390819C153911025 @default.

• next