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• W2000147986 abstract "We hypothesise that developmental arrest in infectious larvae of parasitic nematodes is regulated by signalling pathways homologous to Caenorhabditis elegans DAF (dauer formation) pathways. Alignment of Strongyloides stercoralis (Ss) DAF-2 with DAF-2 of C. elegans and homologs of other species shows that most structural motifs in these insulin-like receptors are conserved. However, the catalytic domain of Ss-DAF-2 contains two substitutions (Q1242 and Q1256), that would result in constitutive dauer formation in C. elegans or diabetes in vertebrate animals. Ss-daf-2 also shows two alternately spliced isoforms, the constitutively expressed Ss-daf-2a, and Ss-daf-2b, which is only expressed in stages leading to parasitism." @default.
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• W2000147986 date "2013-06-01" @default.
• W2000147986 modified "2023-10-16" @default.
• W2000147986 title "Strongyloides stercoralis daf-2 encodes a divergent ortholog of Caenorhabditis elegans DAF-2" @default.
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• W2000147986 doi "https://doi.org/10.1016/j.ijpara.2013.01.008" @default.
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