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- W2000332011 abstract "We have used one activator and two inhibitors of protein kinase C (PKC) to examine the role of this enzyme in the induction of meiotic cell division. At 1 U/ml, phosphatidylcholine-specific phospholipase C increases DAG, alters intracellular pH and inhibits the induction of meiosis by insulin or progesterone. However, when added about 1.6 h after progesterone, the enzyme speeds the induction of cell division. Microinjection of inhibitor peptide (19-36) of PKC has little effect on progesterone action but stimulates the induction of meiosis by insulin. When the inhibitor peptide is injected about 2h after insulin addition, the peptide inhibits. A second PKC inhibitor, staurosporine, decreases PKC-dependent intracellular pH and in vitro oocyte PKC activity. At similar concentrations, staurosporine stimulates insulin or progesterone action, but, when added after about 2 h, the drug inhibits induction by insulin. We conclude that PKC is initially inhibitory to the induction of meiotic cell division but then may become synergistic." @default.
- W2000332011 created "2016-06-24" @default.
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- W2000332011 date "1992-07-01" @default.
- W2000332011 modified "2023-09-25" @default.
- W2000332011 title "Protein kinase C initially inhibits the induction of meiotic cell division in xenopus oocytes" @default.
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- W2000332011 doi "https://doi.org/10.1016/0898-6568(92)90034-6" @default.
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