FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000597410> ?p ?o ?g. }

• W2000597410 endingPage "7649" @default.
• W2000597410 startingPage "7642" @default.
• W2000597410 abstract "The covalent conjugation of polyethylene glycol (PEG, typical MW > 10k) to therapeutic peptides and proteins is a well-established approach to improve their pharmacokinetic properties and diminish the potential for immunogenicity. Even though PEG is generally considered biologically inert and safe in animals and humans, the slow clearance of large PEGs raises concerns about potential adverse effects resulting from PEG accumulation in tissues following chronic administration, particularly in the central nervous system. The key information relevant to the issue is the disposition and fate of the PEG moiety after repeated dosing with PEGylated proteins. Here, we report a novel quantitative method utilizing LC-MS/MS coupled with in-source CID that is highly selective and sensitive to PEG-related materials. Both 40KPEG and a tool PEGylated protein (ATI-1072) underwent dissociation in the ionization source of mass spectrometer to generate a series of PEG-specific ions, which were subjected to further dissociation through conventional CID. To demonstrate the potential application of the method to assess PEG biodistribution following PEGylated protein administration, a single dose study of ATI-1072 was conducted in rats. Plasma and various tissues were collected, and the concentrations of both 40KPEG and ATI-1072 were determined using the LC-MS/MS method. The presence of 40kPEG in plasma and tissue homogenates suggests the degradation of PEGylated proteins after dose administration to rats, given that free PEG was absent in the dosing solution. The method enables further studies for a thorough characterization of disposition and fate of PEGylated proteins." @default.
• W2000597410 created "2016-06-24" @default.
• W2000597410 creator A5018927031 @default.
• W2000597410 creator A5037191805 @default.
• W2000597410 creator A5040434633 @default.
• W2000597410 creator A5053510463 @default.
• W2000597410 creator A5063860917 @default.
• W2000597410 creator A5067875544 @default.
• W2000597410 creator A5068789593 @default.
• W2000597410 creator A5071294871 @default.
• W2000597410 creator A5079619553 @default.
• W2000597410 date "2014-07-08" @default.
• W2000597410 modified "2023-10-16" @default.
• W2000597410 title "Quantitative Analysis of Polyethylene Glycol (PEG) and PEGylated Proteins in Animal Tissues by LC-MS/MS Coupled with In-Source CID" @default.
• W2000597410 cites W1541427249 @default.
• W2000597410 cites W1858853064 @default.
• W2000597410 cites W1897770000 @default.
• W2000597410 cites W1966831912 @default.
• W2000597410 cites W1971645603 @default.
• W2000597410 cites W1974499095 @default.
• W2000597410 cites W1977016781 @default.
• W2000597410 cites W1989408790 @default.
• W2000597410 cites W2004139093 @default.
• W2000597410 cites W2007406685 @default.
• W2000597410 cites W2010506651 @default.
• W2000597410 cites W2013766226 @default.
• W2000597410 cites W2019401925 @default.
• W2000597410 cites W2047188856 @default.
• W2000597410 cites W2054616299 @default.
• W2000597410 cites W2062148840 @default.
• W2000597410 cites W2065876461 @default.
• W2000597410 cites W2073104351 @default.
• W2000597410 cites W2075678951 @default.
• W2000597410 cites W2081306620 @default.
• W2000597410 cites W2090461021 @default.
• W2000597410 cites W2094375186 @default.
• W2000597410 cites W2099936859 @default.
• W2000597410 cites W2112687126 @default.
• W2000597410 cites W2117561430 @default.
• W2000597410 cites W2139708400 @default.
• W2000597410 cites W2146029618 @default.
• W2000597410 cites W2152366942 @default.
• W2000597410 cites W2165390726 @default.
• W2000597410 cites W2166171010 @default.
• W2000597410 cites W2331422587 @default.
• W2000597410 cites W2396487155 @default.
• W2000597410 cites W4253535645 @default.
• W2000597410 doi "https://doi.org/10.1021/ac501507g" @default.
• W2000597410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25003239" @default.
• W2000597410 hasPublicationYear "2014" @default.
• W2000597410 type Work @default.
• W2000597410 sameAs 2000597410 @default.
• W2000597410 citedByCount "31" @default.
• W2000597410 countsByYear W20005974102015 @default.
• W2000597410 countsByYear W20005974102016 @default.
• W2000597410 countsByYear W20005974102017 @default.
• W2000597410 countsByYear W20005974102018 @default.
• W2000597410 countsByYear W20005974102019 @default.
• W2000597410 countsByYear W20005974102020 @default.
• W2000597410 countsByYear W20005974102021 @default.
• W2000597410 countsByYear W20005974102022 @default.
• W2000597410 countsByYear W20005974102023 @default.
• W2000597410 crossrefType "journal-article" @default.
• W2000597410 hasAuthorship W2000597410A5018927031 @default.
• W2000597410 hasAuthorship W2000597410A5037191805 @default.
• W2000597410 hasAuthorship W2000597410A5040434633 @default.
• W2000597410 hasAuthorship W2000597410A5053510463 @default.
• W2000597410 hasAuthorship W2000597410A5063860917 @default.
• W2000597410 hasAuthorship W2000597410A5067875544 @default.
• W2000597410 hasAuthorship W2000597410A5068789593 @default.
• W2000597410 hasAuthorship W2000597410A5071294871 @default.
• W2000597410 hasAuthorship W2000597410A5079619553 @default.
• W2000597410 hasConcept C10138342 @default.
• W2000597410 hasConcept C112705442 @default.
• W2000597410 hasConcept C12554922 @default.
• W2000597410 hasConcept C162324750 @default.
• W2000597410 hasConcept C185592680 @default.
• W2000597410 hasConcept C202751555 @default.
• W2000597410 hasConcept C2776964284 @default.
• W2000597410 hasConcept C2777807558 @default.
• W2000597410 hasConcept C2779149719 @default.
• W2000597410 hasConcept C43617362 @default.
• W2000597410 hasConcept C54400483 @default.
• W2000597410 hasConcept C55493867 @default.
• W2000597410 hasConcept C71924100 @default.
• W2000597410 hasConcept C86803240 @default.
• W2000597410 hasConcept C98274493 @default.
• W2000597410 hasConceptScore W2000597410C10138342 @default.
• W2000597410 hasConceptScore W2000597410C112705442 @default.
• W2000597410 hasConceptScore W2000597410C12554922 @default.
• W2000597410 hasConceptScore W2000597410C162324750 @default.
• W2000597410 hasConceptScore W2000597410C185592680 @default.
• W2000597410 hasConceptScore W2000597410C202751555 @default.
• W2000597410 hasConceptScore W2000597410C2776964284 @default.
• W2000597410 hasConceptScore W2000597410C2777807558 @default.
• W2000597410 hasConceptScore W2000597410C2779149719 @default.
• W2000597410 hasConceptScore W2000597410C43617362 @default.
• W2000597410 hasConceptScore W2000597410C54400483 @default.

• next