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- W2000654425 abstract "As the main microtubule-organizing centre in animal cells, the centrosome has a fundamental role in cell function. Surrounding the centrioles, the pericentriolar material (PCM) provides a dynamic platform for nucleating microtubules. Although the importance of the PCM is established, its amorphous electron-dense nature has made it refractory to structural investigation. By using SIM and STORM subdiffraction-resolution microscopies to visualize proteins critical for centrosome maturation, we demonstrate that the PCM is organized into two main structural domains: a layer juxtaposed to the centriole wall, and proteins extending farther away from the centriole organized in a matrix. Analysis of Pericentrin-like protein (PLP) reveals that its carboxy terminus is positioned at the centriole wall, it radiates outwards into the matrix and is organized in clusters having quasi-nine-fold symmetry. By RNA-mediated interference (RNAi), we show that PLP fibrils are required for interphase recruitment and proper mitotic assembly of the PCM matrix." @default.
- W2000654425 created "2016-06-24" @default.
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- W2000654425 date "2012-10-21" @default.
- W2000654425 modified "2023-09-28" @default.
- W2000654425 title "Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization" @default.
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- W2000654425 doi "https://doi.org/10.1038/ncb2597" @default.
- W2000654425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3767400" @default.
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- W2000654425 hasPublicationYear "2012" @default.
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