FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000734931> ?p ?o ?g. }

• W2000734931 endingPage "e24705" @default.
• W2000734931 startingPage "e24705" @default.
• W2000734931 abstract "Background Immunotherapy is often recommended as an adjuvant treatment to reduce the chance of cancer recurrence or metastasis. Interestingly, timing is very important for a successful immunotherapy against metastasis, although the precise mechanism is still unknown. Methods and Findings Using a mouse model of melanoma metastasis induced by intravenous injection of B16-F10 cells, we investigated the mechanism responsible for the diverse efficacy of the prophylactic or therapeutic TLR4 and TLR9 agonist complex against metastasis. We found that the activation of TLR4 and TLR9 prevented, but did not reverse, metastasis because the potency of this combination was neither sufficient to overcome the tumor cell-educated immune tolerance nor to induce efficacious autophagy in tumor cells. The prophylactic application of the complex promoted antimetastatic immunity, leading to the autophagy-associated death of melanoma cells via IFNγ/STAT1 activation and attenuated tumor metastasis. IFNγ neutralization reversed the prophylactic benefit induced by the complex by suppressing STAT1 activation and attenuating autophagy in mice. However, the therapeutic application of the complex did not suppress metastasis because the complex could not reverse tumor cell-induced STAT3 activation and neither activate IFNγ/STAT1 signaling and autophagy. Suppressing STAT3 activation with the JAK/STAT antagonist AG490 restored the antimetastatic effect of the TLR4/9 agonist complex. Activation of autophagy after tumor inoculation by using rapamycin, with or without the TLR4/9 agonist complex, could suppress metastasis. Conclusion and Significance Our studies suggest that activation of IFNγ/STAT1 signaling and induction of autophagy are critical for an efficacious anti-metastatic immunotherapy and that autophagy activators may overcome the timing barrier for immunotherapy against metastasis." @default.
• W2000734931 created "2016-06-24" @default.
• W2000734931 creator A5008464561 @default.
• W2000734931 creator A5016853386 @default.
• W2000734931 creator A5019117674 @default.
• W2000734931 creator A5020736949 @default.
• W2000734931 creator A5034935082 @default.
• W2000734931 creator A5042414626 @default.
• W2000734931 creator A5063812051 @default.
• W2000734931 creator A5065698756 @default.
• W2000734931 creator A5077019341 @default.
• W2000734931 creator A5078725053 @default.
• W2000734931 creator A5091003916 @default.
• W2000734931 date "2011-09-13" @default.
• W2000734931 modified "2023-10-16" @default.
• W2000734931 title "Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy" @default.
• W2000734931 cites W1872243482 @default.
• W2000734931 cites W1934264881 @default.
• W2000734931 cites W1964361947 @default.
• W2000734931 cites W1967060514 @default.
• W2000734931 cites W1973406626 @default.
• W2000734931 cites W1977830709 @default.
• W2000734931 cites W1980219117 @default.
• W2000734931 cites W1981802408 @default.
• W2000734931 cites W1983989619 @default.
• W2000734931 cites W1987334812 @default.
• W2000734931 cites W1988246030 @default.
• W2000734931 cites W1990316655 @default.
• W2000734931 cites W1990558443 @default.
• W2000734931 cites W1990683510 @default.
• W2000734931 cites W1992699637 @default.
• W2000734931 cites W1996362044 @default.
• W2000734931 cites W2002485558 @default.
• W2000734931 cites W2006182783 @default.
• W2000734931 cites W2014700733 @default.
• W2000734931 cites W2020509129 @default.
• W2000734931 cites W2020920166 @default.
• W2000734931 cites W2021092016 @default.
• W2000734931 cites W2024033490 @default.
• W2000734931 cites W2025665129 @default.
• W2000734931 cites W2042260827 @default.
• W2000734931 cites W2043103956 @default.
• W2000734931 cites W2044227662 @default.
• W2000734931 cites W2046134396 @default.
• W2000734931 cites W2051940924 @default.
• W2000734931 cites W2052997401 @default.
• W2000734931 cites W2077173862 @default.
• W2000734931 cites W2092909221 @default.
• W2000734931 cites W2095371525 @default.
• W2000734931 cites W2097062765 @default.
• W2000734931 cites W2098585201 @default.
• W2000734931 cites W2104414795 @default.
• W2000734931 cites W2124310819 @default.
• W2000734931 cites W2131778873 @default.
• W2000734931 cites W2134197723 @default.
• W2000734931 cites W2137285200 @default.
• W2000734931 cites W2145360982 @default.
• W2000734931 cites W2149323874 @default.
• W2000734931 cites W2316634422 @default.
• W2000734931 doi "https://doi.org/10.1371/journal.pone.0024705" @default.
• W2000734931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172290" @default.
• W2000734931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21931823" @default.
• W2000734931 hasPublicationYear "2011" @default.
• W2000734931 type Work @default.
• W2000734931 sameAs 2000734931 @default.
• W2000734931 citedByCount "29" @default.
• W2000734931 countsByYear W20007349312012 @default.
• W2000734931 countsByYear W20007349312013 @default.
• W2000734931 countsByYear W20007349312015 @default.
• W2000734931 countsByYear W20007349312016 @default.
• W2000734931 countsByYear W20007349312017 @default.
• W2000734931 countsByYear W20007349312018 @default.
• W2000734931 countsByYear W20007349312019 @default.
• W2000734931 countsByYear W20007349312020 @default.
• W2000734931 countsByYear W20007349312021 @default.
• W2000734931 countsByYear W20007349312023 @default.
• W2000734931 crossrefType "journal-article" @default.
• W2000734931 hasAuthorship W2000734931A5008464561 @default.
• W2000734931 hasAuthorship W2000734931A5016853386 @default.
• W2000734931 hasAuthorship W2000734931A5019117674 @default.
• W2000734931 hasAuthorship W2000734931A5020736949 @default.
• W2000734931 hasAuthorship W2000734931A5034935082 @default.
• W2000734931 hasAuthorship W2000734931A5042414626 @default.
• W2000734931 hasAuthorship W2000734931A5063812051 @default.
• W2000734931 hasAuthorship W2000734931A5065698756 @default.
• W2000734931 hasAuthorship W2000734931A5077019341 @default.
• W2000734931 hasAuthorship W2000734931A5078725053 @default.
• W2000734931 hasAuthorship W2000734931A5091003916 @default.
• W2000734931 hasBestOaLocation W20007349311 @default.
• W2000734931 hasConcept C104317684 @default.
• W2000734931 hasConcept C121608353 @default.
• W2000734931 hasConcept C126322002 @default.
• W2000734931 hasConcept C150194340 @default.
• W2000734931 hasConcept C170493617 @default.
• W2000734931 hasConcept C190283241 @default.
• W2000734931 hasConcept C190727270 @default.
• W2000734931 hasConcept C203014093 @default.
• W2000734931 hasConcept C203522944 @default.

• next