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• W2001036730 abstract "Purpose: The transcription factor, NF-kB, is important in the coordinated expressions of various pro-inflammatory and adhesion molecules. Our hypothesis is that inhibiting the action of NF-kB using a synthetic decoy oligodeoxynucleotide (ODN) can block the underlying inflammatory response in glomerulonephritis. Materials and Methods: Forty two male C57BL6 mice, weighting 25g, were divided into four groups; in group 1, 2 mice were used as normal controls; in group 2, a unilateral ureteral obstruction (UUO) was induced in 12 mice; in group 3, 20 UUO mice were treated using ring-type NK-kB decoy ODN; and in group 4, 8 UUO mice were treated using scramble type NF-kB decoy ODN. The mice were killed 1, 3, 5 and 7 days after the NF-kB decoy ODN injections, and the blood urea nitrogen (BUN), and expressions of tumor necrosis factor-α(TNF-α), interleukin-β (IL-β), fibronectin, vascular cell adhesion molecule (VCAM) and monocyte chemotactic protein-1 (MCP-1), as well as the histopathological findings, analyzed in each group. Results: The serum levels of BUN, TNF-α, IL-β, fibronectin, VCAM and MCP-1 were increased in group 2, but decreased in group 3. The histopathological findings of the kidneys in group 3 were most similar to those found in the control (group 1). Conclusions: NF-kB decoy ODN treatment substantially inhibited the disease, with reductions in the histological damage and the renal expressions of inflammatory cytokines. (Korean J Urol 2007;48:815-825) 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏" @default.
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• W2001036730 date "2007-01-01" @default.
• W2001036730 modified "2023-10-16" @default.
• W2001036730 title "The Effect of Ring-type NF-kappa B (NF-kB) Decoy Oligodeoxynucleotide on the Kidney for an Experimental Unilateral Ureteral Obstruction in Mice" @default.
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• W2001036730 doi "https://doi.org/10.4111/kju.2007.48.8.815" @default.
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