Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002053669> ?p ?o ?g. }
- W2002053669 endingPage "5259" @default.
- W2002053669 startingPage "5242" @default.
- W2002053669 abstract "Antigene RNAs (agRNAs) are small RNA duplexes that target non-coding transcripts rather than mRNA and specifically suppress or activate gene expression in a sequence-dependent manner. For many applications in vivo , it is likely that agRNAs will require chemical modification. We have synthesized agRNAs that contain different classes of chemical modification and have tested their ability to modulate expression of the human progesterone receptor gene. We find that both silencing and activating agRNAs can retain activity after modification. Both guide and passenger strands can be modified and functional agRNAs can contain 2′F-RNA, 2′OMe-RNA, and locked nucleic acid substitutions, or combinations of multiple modifications. The mechanism of agRNA activity appears to be maintained after chemical modification: both native and modified agRNAs modulate recruitment of RNA polymerase II, have the same effect on promoter-derived antisense transcripts, and must be double-stranded. These data demonstrate that agRNA activity is compatible with a wide range of chemical modifications and may facilitate in vivo applications." @default.
- W2002053669 created "2016-06-24" @default.
- W2002053669 creator A5044865944 @default.
- W2002053669 creator A5049957906 @default.
- W2002053669 creator A5059841844 @default.
- W2002053669 creator A5072379549 @default.
- W2002053669 creator A5080409747 @default.
- W2002053669 creator A5085203302 @default.
- W2002053669 creator A5088625141 @default.
- W2002053669 date "2010-04-19" @default.
- W2002053669 modified "2023-10-04" @default.
- W2002053669 title "Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters" @default.
- W2002053669 cites W1501059295 @default.
- W2002053669 cites W1611419331 @default.
- W2002053669 cites W1963613302 @default.
- W2002053669 cites W1967317528 @default.
- W2002053669 cites W1968717457 @default.
- W2002053669 cites W1969896048 @default.
- W2002053669 cites W1972637758 @default.
- W2002053669 cites W1980945502 @default.
- W2002053669 cites W1982010715 @default.
- W2002053669 cites W1983595686 @default.
- W2002053669 cites W1984085632 @default.
- W2002053669 cites W1984844589 @default.
- W2002053669 cites W1988471700 @default.
- W2002053669 cites W1992517046 @default.
- W2002053669 cites W1994983564 @default.
- W2002053669 cites W2001765577 @default.
- W2002053669 cites W2003015405 @default.
- W2002053669 cites W2003322056 @default.
- W2002053669 cites W2005880821 @default.
- W2002053669 cites W2006998980 @default.
- W2002053669 cites W2011025558 @default.
- W2002053669 cites W2011480379 @default.
- W2002053669 cites W2017515700 @default.
- W2002053669 cites W2019387053 @default.
- W2002053669 cites W2019631541 @default.
- W2002053669 cites W2019749608 @default.
- W2002053669 cites W2019818589 @default.
- W2002053669 cites W2020368715 @default.
- W2002053669 cites W2023246459 @default.
- W2002053669 cites W2024244702 @default.
- W2002053669 cites W2026457552 @default.
- W2002053669 cites W2028104082 @default.
- W2002053669 cites W2034180036 @default.
- W2002053669 cites W2034709592 @default.
- W2002053669 cites W2038332844 @default.
- W2002053669 cites W2038660811 @default.
- W2002053669 cites W2053370393 @default.
- W2002053669 cites W2058070679 @default.
- W2002053669 cites W2058711543 @default.
- W2002053669 cites W2062253159 @default.
- W2002053669 cites W2068984659 @default.
- W2002053669 cites W2080423827 @default.
- W2002053669 cites W2080853945 @default.
- W2002053669 cites W2081201102 @default.
- W2002053669 cites W2085516557 @default.
- W2002053669 cites W2092225554 @default.
- W2002053669 cites W2092261551 @default.
- W2002053669 cites W2095461860 @default.
- W2002053669 cites W2103892935 @default.
- W2002053669 cites W2105444747 @default.
- W2002053669 cites W2107762071 @default.
- W2002053669 cites W2111066814 @default.
- W2002053669 cites W2115558774 @default.
- W2002053669 cites W2116424844 @default.
- W2002053669 cites W2119293746 @default.
- W2002053669 cites W2121133384 @default.
- W2002053669 cites W2122935177 @default.
- W2002053669 cites W2131246621 @default.
- W2002053669 cites W2134596861 @default.
- W2002053669 cites W2143313350 @default.
- W2002053669 cites W2159595055 @default.
- W2002053669 cites W2161560970 @default.
- W2002053669 cites W2161836629 @default.
- W2002053669 cites W2161872337 @default.
- W2002053669 cites W2166915947 @default.
- W2002053669 cites W2329086168 @default.
- W2002053669 doi "https://doi.org/10.1093/nar/gkq258" @default.
- W2002053669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2926613" @default.
- W2002053669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20403811" @default.
- W2002053669 hasPublicationYear "2010" @default.
- W2002053669 type Work @default.
- W2002053669 sameAs 2002053669 @default.
- W2002053669 citedByCount "38" @default.
- W2002053669 countsByYear W20020536692012 @default.
- W2002053669 countsByYear W20020536692013 @default.
- W2002053669 countsByYear W20020536692014 @default.
- W2002053669 countsByYear W20020536692015 @default.
- W2002053669 countsByYear W20020536692016 @default.
- W2002053669 countsByYear W20020536692017 @default.
- W2002053669 countsByYear W20020536692018 @default.
- W2002053669 countsByYear W20020536692019 @default.
- W2002053669 countsByYear W20020536692020 @default.
- W2002053669 countsByYear W20020536692021 @default.
- W2002053669 countsByYear W20020536692022 @default.
- W2002053669 countsByYear W20020536692023 @default.
- W2002053669 crossrefType "journal-article" @default.