FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003669097> ?p ?o ?g. }

• W2003669097 endingPage "168" @default.
• W2003669097 startingPage "161" @default.
• W2003669097 abstract "Hippocampal slices were incubated in a Krebs-bicarbonate buffer with various concentrations of calcium and [3H]glutamate receptor binding was measured in crude synaptic membranes derived from these slices. Increasing the calcium concentration from 0 to 2.5 mM resulted in a 2.2-fold increase in the maximal number of the Na-independent [3H]glutamate binding sites without changes in their affinity for [3H]glutamate. This effect was totally blocked by the addition of the protease inhibitor leupeptin (50 microM) to the slice incubation medium. No effect was observed on the Na-dependent [3H]glutamate binding nor on the Na-independent [ 3H ]glutamate binding measured in the presence of a concentration of calcium of 250 microM. Increasing the calcium concentration also resulted in an increased proteolytic activity which was inhibited by about 70% by the addition of leupeptin. Finally, increasing the calcium concentration induced the degradation of high-molecular weight proteins, the microtubule-associated proteins (MAPs) and the 220 000 dalton doublet protein corresponding to fodrin. Both effects were partially prevented by the addition of leupeptin in the slice incubation medium. These results indicate that the same calcium-dependent processes which were previously shown to regulate [ 3H ]glutamate receptor binding to hippocampal membranes occur in the hippocampal slice preparation, and they suggest a mechanism by which fluctuations in calcium levels can activate a calcium-dependent proteinase, the degradation of cytoskeletal-associated proteins and the unmasking of additional glutamate receptors. The participation of such processes in various forms of plasticity is discussed." @default.
• W2003669097 created "2016-06-24" @default.
• W2003669097 creator A5012477004 @default.
• W2003669097 creator A5013718948 @default.
• W2003669097 creator A5066306789 @default.
• W2003669097 creator A5074348666 @default.
• W2003669097 date "1983-06-01" @default.
• W2003669097 modified "2023-10-14" @default.
• W2003669097 title "Regulation by calcium ions of glutamate receptor binding in hippocampal slices" @default.
• W2003669097 cites W1570260604 @default.
• W2003669097 cites W1775749144 @default.
• W2003669097 cites W1965515801 @default.
• W2003669097 cites W1966935916 @default.
• W2003669097 cites W1975761737 @default.
• W2003669097 cites W1977247855 @default.
• W2003669097 cites W1982116849 @default.
• W2003669097 cites W1982270009 @default.
• W2003669097 cites W1983571205 @default.
• W2003669097 cites W1998950111 @default.
• W2003669097 cites W2001725885 @default.
• W2003669097 cites W2006422919 @default.
• W2003669097 cites W2009782005 @default.
• W2003669097 cites W2013080645 @default.
• W2003669097 cites W2015200278 @default.
• W2003669097 cites W2026977253 @default.
• W2003669097 cites W2028985682 @default.
• W2003669097 cites W2031003228 @default.
• W2003669097 cites W2038231740 @default.
• W2003669097 cites W2043194007 @default.
• W2003669097 cites W2052585234 @default.
• W2003669097 cites W2056493955 @default.
• W2003669097 cites W2064597801 @default.
• W2003669097 cites W2066658327 @default.
• W2003669097 cites W2067263408 @default.
• W2003669097 cites W2070862647 @default.
• W2003669097 cites W2072871117 @default.
• W2003669097 cites W2100837269 @default.
• W2003669097 cites W4233612735 @default.
• W2003669097 cites W942002394 @default.
• W2003669097 doi "https://doi.org/10.1016/0014-2999(83)90233-9" @default.
• W2003669097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6307724" @default.
• W2003669097 hasPublicationYear "1983" @default.
• W2003669097 type Work @default.
• W2003669097 sameAs 2003669097 @default.
• W2003669097 citedByCount "29" @default.
• W2003669097 countsByYear W20036690972021 @default.
• W2003669097 countsByYear W20036690972022 @default.
• W2003669097 crossrefType "journal-article" @default.
• W2003669097 hasAuthorship W2003669097A5012477004 @default.
• W2003669097 hasAuthorship W2003669097A5013718948 @default.
• W2003669097 hasAuthorship W2003669097A5066306789 @default.
• W2003669097 hasAuthorship W2003669097A5074348666 @default.
• W2003669097 hasConcept C12554922 @default.
• W2003669097 hasConcept C134018914 @default.
• W2003669097 hasConcept C148762608 @default.
• W2003669097 hasConcept C170493617 @default.
• W2003669097 hasConcept C178790620 @default.
• W2003669097 hasConcept C181199279 @default.
• W2003669097 hasConcept C185592680 @default.
• W2003669097 hasConcept C2775883766 @default.
• W2003669097 hasConcept C2776714187 @default.
• W2003669097 hasConcept C519063684 @default.
• W2003669097 hasConcept C55493867 @default.
• W2003669097 hasConcept C61174792 @default.
• W2003669097 hasConcept C67018056 @default.
• W2003669097 hasConcept C86803240 @default.
• W2003669097 hasConceptScore W2003669097C12554922 @default.
• W2003669097 hasConceptScore W2003669097C134018914 @default.
• W2003669097 hasConceptScore W2003669097C148762608 @default.
• W2003669097 hasConceptScore W2003669097C170493617 @default.
• W2003669097 hasConceptScore W2003669097C178790620 @default.
• W2003669097 hasConceptScore W2003669097C181199279 @default.
• W2003669097 hasConceptScore W2003669097C185592680 @default.
• W2003669097 hasConceptScore W2003669097C2775883766 @default.
• W2003669097 hasConceptScore W2003669097C2776714187 @default.
• W2003669097 hasConceptScore W2003669097C519063684 @default.
• W2003669097 hasConceptScore W2003669097C55493867 @default.
• W2003669097 hasConceptScore W2003669097C61174792 @default.
• W2003669097 hasConceptScore W2003669097C67018056 @default.
• W2003669097 hasConceptScore W2003669097C86803240 @default.
• W2003669097 hasIssue "2-3" @default.
• W2003669097 hasLocation W20036690971 @default.
• W2003669097 hasLocation W20036690972 @default.
• W2003669097 hasOpenAccess W2003669097 @default.
• W2003669097 hasPrimaryLocation W20036690971 @default.
• W2003669097 hasRelatedWork W1969083970 @default.
• W2003669097 hasRelatedWork W2031392396 @default.
• W2003669097 hasRelatedWork W2032448810 @default.
• W2003669097 hasRelatedWork W2036099147 @default.
• W2003669097 hasRelatedWork W2045421013 @default.
• W2003669097 hasRelatedWork W2262618923 @default.
• W2003669097 hasRelatedWork W2394315656 @default.
• W2003669097 hasRelatedWork W2423349450 @default.
• W2003669097 hasRelatedWork W2470629442 @default.
• W2003669097 hasRelatedWork W2492123676 @default.
• W2003669097 hasVolume "90" @default.
• W2003669097 isParatext "false" @default.
• W2003669097 isRetracted "false" @default.

• next