FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005087448> ?p ?o ?g. }

• W2005087448 endingPage "373" @default.
• W2005087448 startingPage "367" @default.
• W2005087448 abstract "MicroRNAs have been implicated in drug resistance of osteosarcoma (OS). MicroRNA-301a (miR-301a) is up-regulated and functions as an oncogene in various cancers. However, little is known about the role of miR-301a in drug resistance of OS cells. In this study, we found that doxorubicin induced time-dependent expression of miR-301a in OS cells. Meantime, doxorubicin promoted HMGCR expression and inhibited AMPKα1 expression, which was further facilitated by miR-301a overexpression. Luciferase reporter assay identified AMPKα1 as direct target gene of miR-301a. Notably, miR-301a reduced doxorubicin-induced cell apoptosis whereas anti-miR-301a enhanced apoptosis in OS cells, suggesting that up-regulation of miR-301a contributed to chemoresistance of OS cells. Consistently, our data showed that miR-301a and HMGCR were up-regulated in chemotherapy-resistant OS compared to those in control OS. Our findings suggested that miR-301a might be a potential biomarker for chemotherapy-resistant OS and a promising therapeutic target for overcoming drug resistance of OS." @default.
• W2005087448 created "2016-06-24" @default.
• W2005087448 creator A5033209116 @default.
• W2005087448 creator A5065050299 @default.
• W2005087448 creator A5070024139 @default.
• W2005087448 date "2015-04-01" @default.
• W2005087448 modified "2023-10-09" @default.
• W2005087448 title "MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targeting AMP-activated protein kinase alpha 1" @default.
• W2005087448 cites W1572067593 @default.
• W2005087448 cites W1629660124 @default.
• W2005087448 cites W1967159277 @default.
• W2005087448 cites W1978586581 @default.
• W2005087448 cites W1986042144 @default.
• W2005087448 cites W1988066351 @default.
• W2005087448 cites W1989753563 @default.
• W2005087448 cites W1997245211 @default.
• W2005087448 cites W2006201075 @default.
• W2005087448 cites W2007240877 @default.
• W2005087448 cites W2008886404 @default.
• W2005087448 cites W2008945738 @default.
• W2005087448 cites W2009506181 @default.
• W2005087448 cites W2027378292 @default.
• W2005087448 cites W2028197291 @default.
• W2005087448 cites W2040153093 @default.
• W2005087448 cites W2051818991 @default.
• W2005087448 cites W2053855502 @default.
• W2005087448 cites W2060790852 @default.
• W2005087448 cites W2067287500 @default.
• W2005087448 cites W2070571588 @default.
• W2005087448 cites W2070834113 @default.
• W2005087448 cites W2088230889 @default.
• W2005087448 cites W2090371957 @default.
• W2005087448 cites W2107535232 @default.
• W2005087448 cites W2114828347 @default.
• W2005087448 cites W2131112855 @default.
• W2005087448 cites W2137443978 @default.
• W2005087448 cites W2147457533 @default.
• W2005087448 cites W2149954427 @default.
• W2005087448 cites W2158657686 @default.
• W2005087448 cites W2162465955 @default.
• W2005087448 cites W2168496018 @default.
• W2005087448 cites W24242075 @default.
• W2005087448 cites W4233116228 @default.
• W2005087448 doi "https://doi.org/10.1016/j.bbrc.2015.02.101" @default.
• W2005087448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25727016" @default.
• W2005087448 hasPublicationYear "2015" @default.
• W2005087448 type Work @default.
• W2005087448 sameAs 2005087448 @default.
• W2005087448 citedByCount "63" @default.
• W2005087448 countsByYear W20050874482015 @default.
• W2005087448 countsByYear W20050874482016 @default.
• W2005087448 countsByYear W20050874482017 @default.
• W2005087448 countsByYear W20050874482018 @default.
• W2005087448 countsByYear W20050874482019 @default.
• W2005087448 countsByYear W20050874482020 @default.
• W2005087448 countsByYear W20050874482021 @default.
• W2005087448 countsByYear W20050874482022 @default.
• W2005087448 countsByYear W20050874482023 @default.
• W2005087448 crossrefType "journal-article" @default.
• W2005087448 hasAuthorship W2005087448A5033209116 @default.
• W2005087448 hasAuthorship W2005087448A5065050299 @default.
• W2005087448 hasAuthorship W2005087448A5070024139 @default.
• W2005087448 hasConcept C104317684 @default.
• W2005087448 hasConcept C114851261 @default.
• W2005087448 hasConcept C145059251 @default.
• W2005087448 hasConcept C184235292 @default.
• W2005087448 hasConcept C190283241 @default.
• W2005087448 hasConcept C2776694085 @default.
• W2005087448 hasConcept C2777760704 @default.
• W2005087448 hasConcept C2780124434 @default.
• W2005087448 hasConcept C2781018059 @default.
• W2005087448 hasConcept C2781303535 @default.
• W2005087448 hasConcept C29537977 @default.
• W2005087448 hasConcept C502942594 @default.
• W2005087448 hasConcept C54355233 @default.
• W2005087448 hasConcept C55493867 @default.
• W2005087448 hasConcept C86803240 @default.
• W2005087448 hasConcept C89423630 @default.
• W2005087448 hasConcept C95444343 @default.
• W2005087448 hasConcept C97029542 @default.
• W2005087448 hasConceptScore W2005087448C104317684 @default.
• W2005087448 hasConceptScore W2005087448C114851261 @default.
• W2005087448 hasConceptScore W2005087448C145059251 @default.
• W2005087448 hasConceptScore W2005087448C184235292 @default.
• W2005087448 hasConceptScore W2005087448C190283241 @default.
• W2005087448 hasConceptScore W2005087448C2776694085 @default.
• W2005087448 hasConceptScore W2005087448C2777760704 @default.
• W2005087448 hasConceptScore W2005087448C2780124434 @default.
• W2005087448 hasConceptScore W2005087448C2781018059 @default.
• W2005087448 hasConceptScore W2005087448C2781303535 @default.
• W2005087448 hasConceptScore W2005087448C29537977 @default.
• W2005087448 hasConceptScore W2005087448C502942594 @default.
• W2005087448 hasConceptScore W2005087448C54355233 @default.
• W2005087448 hasConceptScore W2005087448C55493867 @default.
• W2005087448 hasConceptScore W2005087448C86803240 @default.
• W2005087448 hasConceptScore W2005087448C89423630 @default.
• W2005087448 hasConceptScore W2005087448C95444343 @default.
• W2005087448 hasConceptScore W2005087448C97029542 @default.

• next