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• W2005371462 startingPage "75" @default.
• W2005371462 abstract "Spreading depression (SD) confers either increased susceptibility to ischemic injury or a delayed protection. Because nitric oxide modulates ischemic injury, we investigated if altered expression of nitric oxide synthase (NOS) by SD could account for the effect of SD on ischemia. Furthermore, the identity of cells expressing NOS after SD is important, since SD results in heterogeneous, cell type–specific changes in intracellular environment, which can control NOS activity. Immunohistochemical, computer-based image analyses and Western blotting show that the number of neuronal NOS (nNOS)–positive cells in the somatosensory cortex was significantly increased at 6 hours and 3 days after SD ( P < 0.05 and 0.01, respectively), whereas inducible NOS expression remained unchanged. Double-labeling of nNOS and glial fibrillary acidic protein identified these nNOS-positive cells as astrocytes. The effect of altered NO production on induced nNOS expression was examined by treating rats with sodium nitroprusside or N A -nitro-L-arginine methyl ester (LNAM) during SD. Increased nNOS expression was prevented by sodium nitroprusside and phenylephrine or phenylephrine alone, but not LNAM. Because SD increased astrocytic nNOS expression at time points correlating with both ischemic hypersensitivity and ischemic tolerance, the ability of SD to modulate ischemic injury must be complex, perhaps involving NOS but other factors as well." @default.
• W2005371462 created "2016-06-24" @default.
• W2005371462 creator A5006243207 @default.
• W2005371462 creator A5008451707 @default.
• W2005371462 date "1998-01-01" @default.
• W2005371462 modified "2023-09-25" @default.
• W2005371462 title "Neuronal Nitric Oxide Synthase Expression is Induced in Neocortical Astrocytes after Spreading Depression" @default.
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• W2005371462 doi "https://doi.org/10.1097/00004647-199801000-00008" @default.
• W2005371462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2698993" @default.
• W2005371462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9428308" @default.
• W2005371462 hasPublicationYear "1998" @default.
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