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- W2007353602 abstract "Overproduction of the amyloid β (Aβ) peptide is a key factor in the pathogenesis of Alzheimer's disease (AD), but the mechanisms of its pathogenic effects have not been defined. Patients with AD have cerebrovascular alterations attributable to the deleterious effects of Aβ on cerebral blood vessels. We report here that NADPH oxidase, the major source of free radicals in blood vessels, is responsible for the cerebrovascular dysregulation induced by Aβ. Thus, the free-radical production and the associated alterations in vasoregulation induced by Aβ are abrogated by the NADPH oxidase peptide inhibitor gp91ds-tat and are not observed in mice lacking the catalytic subunit of NADPH oxidase (gp91 phox ). Furthermore, oxidative stress and cerebrovascular dysfunction do not occur in transgenic mice overexpressing the amyloid precursor protein but lacking gp91 phox . The mechanisms by which NADPH oxidase-derived radicals mediate the cerebrovascular dysfunction involve reduced bioavailability of nitric oxide. Thus, a gp91 phox -containing NADPH oxidase is the critical link between Aβ and cerebrovascular dysfunction, which may underlie the alteration in cerebral blood flow regulation observed in AD patients." @default.
- W2007353602 created "2016-06-24" @default.
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- W2007353602 date "2005-02-16" @default.
- W2007353602 modified "2023-10-14" @default.
- W2007353602 title "NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide" @default.
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- W2007353602 doi "https://doi.org/10.1523/jneurosci.5207-04.2005" @default.
- W2007353602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6725936" @default.
- W2007353602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15716413" @default.
- W2007353602 hasPublicationYear "2005" @default.