FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007983670> ?p ?o ?g. }

• W2007983670 endingPage "128" @default.
• W2007983670 startingPage "121" @default.
• W2007983670 abstract "A new glucose-responsive insulin delivery system composed of phenylboronic acid (PBA) groups was prepared and investigated. Complexation of various diol-containing molecules with PBA gel beads was evaluated using frontal chromatography. The structural features of the diol-containing molecules strongly influenced their binding to PBA gel beads. In particular, open-chain monosaccharides demonstrated higher association constants (ca 9.5 × 102 to 5.1 × 103l/mol) than glucose (ca 6.3 × 102 l/mol). Furthermore, a model system utilizing a fluorescent derivative of tris(hydroxymethyl)aminomethane was synthesized and bound to PBA gel beads. The molecules were released in a pulsatile manner in response to glucose. In addition, gluconic acids were chemically attached to insulin molecules. The modified insulin, containing two gluconic acid units per insulin molecule, was isolated using ion-exchange chromatography. This gluconic acid-modified insulin (G-lns) was bound onto a PBA gel column, and the G-lns release profile in response to varying glucose concentrations was investigated. The results demonstrate that the PBA gel beads release G-Ins in response to glucose concentration. Thus, this new system may be applied for self-regulated insulin delivery." @default.
• W2007983670 created "2016-06-24" @default.
• W2007983670 creator A5015097923 @default.
• W2007983670 creator A5015662992 @default.
• W2007983670 creator A5046565682 @default.
• W2007983670 creator A5080764583 @default.
• W2007983670 creator A5081446507 @default.
• W2007983670 creator A5082341786 @default.
• W2007983670 creator A5083600733 @default.
• W2007983670 date "1994-01-01" @default.
• W2007983670 modified "2023-10-18" @default.
• W2007983670 title "Preparation and characterization of a glucose-responsive insulin-releasing polymer device" @default.
• W2007983670 cites W128461984 @default.
• W2007983670 cites W1534675934 @default.
• W2007983670 cites W1573056522 @default.
• W2007983670 cites W1591601762 @default.
• W2007983670 cites W1972408434 @default.
• W2007983670 cites W1973406206 @default.
• W2007983670 cites W2004264879 @default.
• W2007983670 cites W2006894689 @default.
• W2007983670 cites W2010083590 @default.
• W2007983670 cites W2019587160 @default.
• W2007983670 cites W2032978059 @default.
• W2007983670 cites W2050132624 @default.
• W2007983670 cites W2060474554 @default.
• W2007983670 cites W2063565876 @default.
• W2007983670 cites W2064750009 @default.
• W2007983670 cites W2074585463 @default.
• W2007983670 cites W2077672576 @default.
• W2007983670 cites W2079414490 @default.
• W2007983670 cites W2084264197 @default.
• W2007983670 cites W2091288913 @default.
• W2007983670 cites W2091969988 @default.
• W2007983670 cites W2092154008 @default.
• W2007983670 cites W2092222250 @default.
• W2007983670 cites W2092799291 @default.
• W2007983670 cites W2124495875 @default.
• W2007983670 cites W2156224745 @default.
• W2007983670 cites W2313658489 @default.
• W2007983670 cites W416161111 @default.
• W2007983670 cites W60660111 @default.
• W2007983670 doi "https://doi.org/10.1016/0142-9612(94)90261-5" @default.
• W2007983670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8011858" @default.
• W2007983670 hasPublicationYear "1994" @default.
• W2007983670 type Work @default.
• W2007983670 sameAs 2007983670 @default.
• W2007983670 citedByCount "133" @default.
• W2007983670 countsByYear W20079836702012 @default.
• W2007983670 countsByYear W20079836702013 @default.
• W2007983670 countsByYear W20079836702014 @default.
• W2007983670 countsByYear W20079836702015 @default.
• W2007983670 countsByYear W20079836702016 @default.
• W2007983670 countsByYear W20079836702017 @default.
• W2007983670 countsByYear W20079836702018 @default.
• W2007983670 countsByYear W20079836702019 @default.
• W2007983670 countsByYear W20079836702020 @default.
• W2007983670 countsByYear W20079836702021 @default.
• W2007983670 countsByYear W20079836702022 @default.
• W2007983670 countsByYear W20079836702023 @default.
• W2007983670 crossrefType "journal-article" @default.
• W2007983670 hasAuthorship W2007983670A5015097923 @default.
• W2007983670 hasAuthorship W2007983670A5015662992 @default.
• W2007983670 hasAuthorship W2007983670A5046565682 @default.
• W2007983670 hasAuthorship W2007983670A5080764583 @default.
• W2007983670 hasAuthorship W2007983670A5081446507 @default.
• W2007983670 hasAuthorship W2007983670A5082341786 @default.
• W2007983670 hasAuthorship W2007983670A5083600733 @default.
• W2007983670 hasConcept C118859902 @default.
• W2007983670 hasConcept C134018914 @default.
• W2007983670 hasConcept C161790260 @default.
• W2007983670 hasConcept C178790620 @default.
• W2007983670 hasConcept C185592680 @default.
• W2007983670 hasConcept C188027245 @default.
• W2007983670 hasConcept C192562407 @default.
• W2007983670 hasConcept C2777734296 @default.
• W2007983670 hasConcept C2779306644 @default.
• W2007983670 hasConcept C2779515768 @default.
• W2007983670 hasConcept C2780388412 @default.
• W2007983670 hasConcept C2780591741 @default.
• W2007983670 hasConcept C32909587 @default.
• W2007983670 hasConcept C43617362 @default.
• W2007983670 hasConcept C55493867 @default.
• W2007983670 hasConcept C71924100 @default.
• W2007983670 hasConceptScore W2007983670C118859902 @default.
• W2007983670 hasConceptScore W2007983670C134018914 @default.
• W2007983670 hasConceptScore W2007983670C161790260 @default.
• W2007983670 hasConceptScore W2007983670C178790620 @default.
• W2007983670 hasConceptScore W2007983670C185592680 @default.
• W2007983670 hasConceptScore W2007983670C188027245 @default.
• W2007983670 hasConceptScore W2007983670C192562407 @default.
• W2007983670 hasConceptScore W2007983670C2777734296 @default.
• W2007983670 hasConceptScore W2007983670C2779306644 @default.
• W2007983670 hasConceptScore W2007983670C2779515768 @default.
• W2007983670 hasConceptScore W2007983670C2780388412 @default.
• W2007983670 hasConceptScore W2007983670C2780591741 @default.
• W2007983670 hasConceptScore W2007983670C32909587 @default.
• W2007983670 hasConceptScore W2007983670C43617362 @default.
• W2007983670 hasConceptScore W2007983670C55493867 @default.

• next