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• W2008045273 abstract "Most toxicological studies have tested single chemical agents at relatively high doses, and fewer studies have addressed the toxic effects of chemical interactions. It is important to understand the toxicity of chemical mixtures in order to assess the more realistic risks of environmental and occupational exposures. A number of chemicals are known to induce a predominantly postaxial forelimb ectrodactyly in C57BL/6 mice, including acetazolamide, ethanol, cadmium, valproic acid, carbon dioxide, dimethadione, phenytoin, and 13-cis-retinoic acid and all-trans-retinoic acid (RA). In the present study, the interactive effects of coadministration of cadmium and RA on developing limbs were investigated.Pregnant C57BL/6 mice were treated with different intraperitoneal (IP) doses of cadmium chloride (CdCl2) and/or RA on gestational day (GD) 9.5, and fetuses were collected on GD 18 and double stained for examination of skeletal defects.When RA was given simultaneously with cadmium, a significant increase in the incidence and severity of forelimb ectrodactyly (predominantly postaxial) was observed compared to the results with corresponding doses of cadmium or RA alone. When mice were exposed to subthreshold doses of both cadmium (0.5 mg/kg) and RA (1 mg/kg), the combined treatment exceeded the threshold, resulting in forelimb ectrodactyly in 19% of the fetuses. Moreover, coadministration of cadmium and RA at doses exceeding the respective thresholds showed a synergistic effect, that is, 92% of fetuses were found with the forelimb defect as opposed to 10% if the response were additive.The findings demonstrate that concurrent exposure to these teratogens can have a synergistic effect and that subteratogenic doses may combine to exceed a threshold." @default.
• W2008045273 created "2016-06-24" @default.
• W2008045273 creator A5011244549 @default.
• W2008045273 creator A5035750579 @default.
• W2008045273 creator A5048281372 @default.
• W2008045273 creator A5064349824 @default.
• W2008045273 date "2006-01-01" @default.
• W2008045273 modified "2023-09-24" @default.
• W2008045273 title "Interactive effects of cadmium and all-trans-retinoic acid on the induction of forelimb ectrodactyly in C57BL/6 mice" @default.
• W2008045273 cites W176530860 @default.
• W2008045273 cites W1841957993 @default.
• W2008045273 cites W1947039862 @default.
• W2008045273 cites W1969602231 @default.
• W2008045273 cites W1972004698 @default.
• W2008045273 cites W1973891854 @default.
• W2008045273 cites W1974562202 @default.
• W2008045273 cites W1978199509 @default.
• W2008045273 cites W1978423325 @default.
• W2008045273 cites W1981145359 @default.
• W2008045273 cites W1982994930 @default.
• W2008045273 cites W1983034169 @default.
• W2008045273 cites W1984320235 @default.
• W2008045273 cites W1986547597 @default.
• W2008045273 cites W1990789332 @default.
• W2008045273 cites W1992776027 @default.
• W2008045273 cites W1993215964 @default.
• W2008045273 cites W1995325690 @default.
• W2008045273 cites W1997717120 @default.
• W2008045273 cites W1998952177 @default.
• W2008045273 cites W2000025640 @default.
• W2008045273 cites W2000146509 @default.
• W2008045273 cites W2000925204 @default.
• W2008045273 cites W2002279090 @default.
• W2008045273 cites W2005236657 @default.
• W2008045273 cites W2005698849 @default.
• W2008045273 cites W2006553971 @default.
• W2008045273 cites W2009610545 @default.
• W2008045273 cites W2009784162 @default.
• W2008045273 cites W2009830714 @default.
• W2008045273 cites W2011077582 @default.
• W2008045273 cites W2013589663 @default.
• W2008045273 cites W2015091248 @default.
• W2008045273 cites W2017302789 @default.
• W2008045273 cites W2022728886 @default.
• W2008045273 cites W2025510871 @default.
• W2008045273 cites W2026962733 @default.
• W2008045273 cites W2035204919 @default.
• W2008045273 cites W2036920124 @default.
• W2008045273 cites W2037067089 @default.
• W2008045273 cites W2037360623 @default.
• W2008045273 cites W2038863612 @default.
• W2008045273 cites W2039013494 @default.
• W2008045273 cites W2043518716 @default.
• W2008045273 cites W2044112975 @default.
• W2008045273 cites W2044159756 @default.
• W2008045273 cites W2044781471 @default.
• W2008045273 cites W2047204411 @default.
• W2008045273 cites W2047431072 @default.
• W2008045273 cites W2047647310 @default.
• W2008045273 cites W2049192197 @default.
• W2008045273 cites W2049781770 @default.
• W2008045273 cites W2050512725 @default.
• W2008045273 cites W2052147027 @default.
• W2008045273 cites W2052599460 @default.
• W2008045273 cites W2059512302 @default.
• W2008045273 cites W2061570844 @default.
• W2008045273 cites W2062933352 @default.
• W2008045273 cites W2067084274 @default.
• W2008045273 cites W2068524933 @default.
• W2008045273 cites W2068982864 @default.
• W2008045273 cites W2071743920 @default.
• W2008045273 cites W2073017696 @default.
• W2008045273 cites W2073221154 @default.
• W2008045273 cites W2074227902 @default.
• W2008045273 cites W2075917937 @default.
• W2008045273 cites W2078568598 @default.
• W2008045273 cites W2080877192 @default.
• W2008045273 cites W2080982151 @default.
• W2008045273 cites W2083027655 @default.
• W2008045273 cites W2086005052 @default.
• W2008045273 cites W2087630663 @default.
• W2008045273 cites W2093205087 @default.
• W2008045273 cites W2093344428 @default.
• W2008045273 cites W2101237598 @default.
• W2008045273 cites W2106317671 @default.
• W2008045273 cites W2106907374 @default.
• W2008045273 cites W2118141024 @default.
• W2008045273 cites W2123363472 @default.
• W2008045273 cites W2132837491 @default.
• W2008045273 cites W2133413328 @default.
• W2008045273 cites W2141478391 @default.
• W2008045273 cites W2144359607 @default.
• W2008045273 cites W2153993860 @default.
• W2008045273 cites W2155211179 @default.
• W2008045273 cites W2155664391 @default.
• W2008045273 cites W2158035714 @default.
• W2008045273 cites W2200373941 @default.
• W2008045273 cites W2327097432 @default.

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