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- W2011851575 abstract "On peripheral noradrenergic nerve endings there exist beta-adrenoreceptors activation of which results in an enhanced release of noradrenaline in response to nerve stimulation. These presynapatic beta-adrenoreceptors do not appear to be activated by neuronally-released noradrenaline. However, adrenaline may be a physiological activator during enhanced adrenomedullary secretion. Adrenaline can also be incorporated into the noradrenergic transmitter stores and be released as a co-transmitter. Under these conditions presynaptic beta-adrenoreceptors may be activated by neuronally-released adrenaline, thus forming a 'positive feedback loop'. The release of adrenaline from the adrenal medullae may also be modulated through facilitatory beta-adrenoreceptors, but the release of noradrenaline from noradrenergic nerves in the central nervous system is not. The facilitatory presynaptic beta-adrenoreceptors appear to be in the main of the beta 2-subtype although precise receptor characterization has not been carried out. Increased activation of presynaptic beta-adrenoreceptors by adrenaline may be implicated in the development of essential hypertension. Part of the antihypertensive action of beta-adrenoreceptor blocking drugs may be due to blockade of these facilitatory presynaptic beta-adrenoreceptors." @default.
- W2011851575 created "2016-06-24" @default.
- W2011851575 creator A5050661550 @default.
- W2011851575 date "1983-03-01" @default.
- W2011851575 modified "2023-09-26" @default.
- W2011851575 title "MODULATION OF NORADRENALINE RELEASE THROUGH ACTIVATION OF PRESYNAPTIC β-ADRENORECEPTORS" @default.
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- W2011851575 doi "https://doi.org/10.1111/j.1474-8673.1983.tb00496.x" @default.
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