FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013287796> ?p ?o ?g. }

• W2013287796 endingPage "57" @default.
• W2013287796 startingPage "51" @default.
• W2013287796 abstract "Luteinizing hormone-releasing hormone (LHRH) is the key regulator of the hypothalamic-pituitary-gonadal (HPG) axis, which is responsible for the development and functioning of the reproductive system. Delivery of a continuous supply of LHRH agonists causes down-regulation of the LHRH receptors, resulting in a marked decrease in androgens in males and estrogens in females. LHRH analogues are widely used in the treatment of various diseases, including prostate and breast cancer, and reproductive disorders, such as infertility and precocious puberty. However, they require parenteral administration, and no oral formulations are currently available. We synthesized two types of LHRH mini-dendrimers using thioether ligation, aiming to enhance the stability and bioavailability of the peptide drug while maintaining its biologically active conformation. These two compounds include a poly-lysine core conjugated to either the C-terminus of LHRH or a D-amino acid in position 6 of the LHRH sequence. The synthesized dendrimers were analysed using dynamic light scattering, and showed particle sizes of 155 and 115 nm, respectively. The nanometer size, well-defined structure and water solubility of these dendritic analogues make them excellent candidates for further exploration in oral peptide drug delivery." @default.
• W2013287796 created "2016-06-24" @default.
• W2013287796 creator A5005723083 @default.
• W2013287796 creator A5008581557 @default.
• W2013287796 creator A5056684373 @default.
• W2013287796 creator A5060304924 @default.
• W2013287796 date "2013-01-01" @default.
• W2013287796 modified "2023-10-18" @default.
• W2013287796 title "Synthesis and Characterization of Luteinizing Hormone-Releasing Hormone (LHRH)-Functionalized Mini-Dendrimers" @default.
• W2013287796 cites W18145089 @default.
• W2013287796 cites W1973061187 @default.
• W2013287796 cites W1976687715 @default.
• W2013287796 cites W1985052696 @default.
• W2013287796 cites W1998019495 @default.
• W2013287796 cites W1999147047 @default.
• W2013287796 cites W2009500363 @default.
• W2013287796 cites W2020373947 @default.
• W2013287796 cites W2030537485 @default.
• W2013287796 cites W2039123138 @default.
• W2013287796 cites W2042415727 @default.
• W2013287796 cites W2050651023 @default.
• W2013287796 cites W2055249600 @default.
• W2013287796 cites W2055366590 @default.
• W2013287796 cites W2067516397 @default.
• W2013287796 cites W2072158142 @default.
• W2013287796 cites W2072952339 @default.
• W2013287796 cites W2074185602 @default.
• W2013287796 cites W2086471490 @default.
• W2013287796 cites W2113606878 @default.
• W2013287796 cites W2117624423 @default.
• W2013287796 cites W2141582604 @default.
• W2013287796 cites W2915367047 @default.
• W2013287796 cites W4230106050 @default.
• W2013287796 cites W4376849580 @default.
• W2013287796 doi "https://doi.org/10.4236/ijoc.2013.31006" @default.
• W2013287796 hasPublicationYear "2013" @default.
• W2013287796 type Work @default.
• W2013287796 sameAs 2013287796 @default.
• W2013287796 citedByCount "4" @default.
• W2013287796 countsByYear W20132877962014 @default.
• W2013287796 countsByYear W20132877962017 @default.
• W2013287796 countsByYear W20132877962020 @default.
• W2013287796 countsByYear W20132877962021 @default.
• W2013287796 crossrefType "journal-article" @default.
• W2013287796 hasAuthorship W2013287796A5005723083 @default.
• W2013287796 hasAuthorship W2013287796A5008581557 @default.
• W2013287796 hasAuthorship W2013287796A5056684373 @default.
• W2013287796 hasAuthorship W2013287796A5060304924 @default.
• W2013287796 hasBestOaLocation W20132877961 @default.
• W2013287796 hasConcept C114373084 @default.
• W2013287796 hasConcept C126322002 @default.
• W2013287796 hasConcept C134018914 @default.
• W2013287796 hasConcept C178790620 @default.
• W2013287796 hasConcept C181389837 @default.
• W2013287796 hasConcept C185592680 @default.
• W2013287796 hasConcept C202751555 @default.
• W2013287796 hasConcept C2778032875 @default.
• W2013287796 hasConcept C2778575703 @default.
• W2013287796 hasConcept C2779281246 @default.
• W2013287796 hasConcept C2779820397 @default.
• W2013287796 hasConcept C55493867 @default.
• W2013287796 hasConcept C55637122 @default.
• W2013287796 hasConcept C71315377 @default.
• W2013287796 hasConcept C71924100 @default.
• W2013287796 hasConcept C98274493 @default.
• W2013287796 hasConceptScore W2013287796C114373084 @default.
• W2013287796 hasConceptScore W2013287796C126322002 @default.
• W2013287796 hasConceptScore W2013287796C134018914 @default.
• W2013287796 hasConceptScore W2013287796C178790620 @default.
• W2013287796 hasConceptScore W2013287796C181389837 @default.
• W2013287796 hasConceptScore W2013287796C185592680 @default.
• W2013287796 hasConceptScore W2013287796C202751555 @default.
• W2013287796 hasConceptScore W2013287796C2778032875 @default.
• W2013287796 hasConceptScore W2013287796C2778575703 @default.
• W2013287796 hasConceptScore W2013287796C2779281246 @default.
• W2013287796 hasConceptScore W2013287796C2779820397 @default.
• W2013287796 hasConceptScore W2013287796C55493867 @default.
• W2013287796 hasConceptScore W2013287796C55637122 @default.
• W2013287796 hasConceptScore W2013287796C71315377 @default.
• W2013287796 hasConceptScore W2013287796C71924100 @default.
• W2013287796 hasConceptScore W2013287796C98274493 @default.
• W2013287796 hasIssue "01" @default.
• W2013287796 hasLocation W20132877961 @default.
• W2013287796 hasLocation W20132877962 @default.
• W2013287796 hasOpenAccess W2013287796 @default.
• W2013287796 hasPrimaryLocation W20132877961 @default.
• W2013287796 hasRelatedWork W1978930457 @default.
• W2013287796 hasRelatedWork W1988486434 @default.
• W2013287796 hasRelatedWork W1991634850 @default.
• W2013287796 hasRelatedWork W2043067495 @default.
• W2013287796 hasRelatedWork W2047880909 @default.
• W2013287796 hasRelatedWork W2053271595 @default.
• W2013287796 hasRelatedWork W2074431763 @default.
• W2013287796 hasRelatedWork W2123666549 @default.
• W2013287796 hasRelatedWork W2133240828 @default.
• W2013287796 hasRelatedWork W2411910748 @default.
• W2013287796 hasVolume "03" @default.
• W2013287796 isParatext "false" @default.

• next